“a strong trend”

After analyzing data from the first ten participants, a preplanned interim analysis using O’Brien-Fleming criteria (p-value threshold of 0.0051) showed a strong trend toward negative results for our key outcomes (GIR and FMD).

These data suggest a strong trend that fibroblasts, smooth muscle cells, and endothelial cells cultured using these traditional in vitro models mirror known responses in fibrosis.

A strong trend of elevated ATM phosphorylation at S1981 was also seen.

However, a strong trend of increased relative Lactobacillus and Bifidobacterium abundances, and certain species within these genera, emerged (Kato et al., 2004 ; Matsumoto et al., 2010 ; Sprong et al., 2010 ; Veiga et al., 2010 , 2014 ; Liu et al., 2015 ; Yilmaz et al., 2019 ; Li et al., 2020 ; Zhang et al., 2020 ).

While there is a strong trend in the literature supporting a gradual reduction in microbial diversity (and subsequent disruption of metavirome profiles) concomitant with westernization 50 , the latter did not translate into a clear-cut geographical trend in regards to the defensome (Fig. 3c and Supplementary Fig. 5c ).

The animal is most likely to enter the maze within the first minute of its return to the cage ( Figure 1—figure supplement 3 ), a strong trend that runs opposite to the prediction from satiation of curiosity.

For 183 kDa PS, average strain at failure was observed to be greater in the FOW measurements, whereas yield stress did not show a strong trend (Supplementary Figs.

Although baseline renal function was not statistically different between these two groups, the LMWD group demonstrated a strong trend toward the progression of renal insufficiency as indicated by the greater change in serum creatinine level during the 1-year follow-up compared with the control group.

Although RI was not significantly different between Smoke‐NC and Smoke‐ HSALR1 , there was a strong trend towards a difference (Figure 7D ).

their clinical ability with the CBCT and the interpretation of the images) were all important factors that affected the accuracy of the VRF detection.[ 21 41 43 44 45 ] Our results clearly reveal the controversy in the literature; however, there is, indeed, a strong trend toward supporting the use of CBCT for the detection and diagnoses of VRFs.

Where some of the reflectance bands do not show a strong trend, they will dampen the signal of the change in true colour.

In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent.

Furthermore, we also detected a strong trend towards increased Myog expression in mice immediately after low-intensity exercise.

In our case, we hypothesize that after compression of the barriers, TAPB monomers tend to stack together and then react with the other monomers to form multilayers, in which there’s a strong trend to be aligned and form AA stacking.

Furthermore, in our trial, RUX also showed a strong trend towards reduction of patient-reported night sweats, while patient-reported bone pain, an additional common symptom in PV pts [ 4 ], scores remained unaltered.

In the cohort of women who initiated MHT closer to the time of menopause, there was a strong trend towards decreased CV risk [ 181 ].

Preserved kidney function would normally translate into less ESKD: We observed a strong trend for this to take place, though we conclude more carefully for ESKD whether our hypertensive patients had DM or not.

1 C) between the four groups; however, a strong trend was observed suggesting a difference in feed efficiency between WT and KO mice ( Fig. 1 D, P genotype = 0.054).

The expression of CXCL8 showed a strong trend towards upregulation, and the expression of JUN and DUSP1 was significantly upregulated after 60 and 90 min when compared to the early time points phb and 30 min ( Figure 4 a,b).

In addition, Np-HSA shows a strong trend towards increased cell viability in the population studied.

In addition, there was a strong trend that found that children with stunting had high EBV viral loads.

Nevertheless, gastroenterological and lung irAEs showed a strong trend in improving PFS (HR 0.77, 95% CI 0.45–1.33, I 2 = 75.9% and HR 0.74, 95% CI 0.58–0.94, I 2 = 44.2%, respectively) and OS (HR 0.62, 95% CI 0.47, 0.81, I 2 = 49.7% and HR 0.59, 95% CI 0.34–1.04, I 2 = 30.4%, respectively) when compared to non-irAEs patients ( Table 3 and Figure 6 ).

The average number of authors per publication was 6.15, indicating a strong trend toward collaborative research in this field.

A strong trend for a higher fraction of committed adipocyte precursors was observed in flow-sorted APC populations from the low n6/n3 consuming litters, with no change in total cell numbers (p = 0.06, Figure 3 A panel 3), indicating that a ready pool of preadipocytes exists.

Species richness and flower abundance of plants surrounding the single-plant isolates in the intensively managed meadows showed a positive relationship or a strong trend for a positive relationship, respectively, with seed set of C. jacea isolates ( Table 2 ; Fig. 2 ).