Conversely, the 4-week group exhibited a strong trend toward neural adaptation at treatment completion (Visit 2, Day 28), where the mean increase in tear secretion was markedly attenuated and no longer reached conventional statistical significance (7.58 ± 4.98 mm/5 min pre-stimulation vs. 8.76 ± 4.92 mm/5 min post-stimulation, Δ = 1.18 ± 4.17 mm/5 min, 95% CI: − 0.01 to 2.37 mm/5 min, P = 0.051, Cohen's d = 0.28 ; Fig. 2 c).
We similarly observed a trend toward an increase in ABCA1 protein in the EGG group from baseline to week 12 ( P = 0.07; data not shown), as well as a strong trend toward greater percent change in ABCA1 protein from baseline in the EGG group (+5.5% ± 9.4%) when compared to the SUB group (−1.9% ± 7.1%) ( Figure 3 E).
We found no significant differences between any combination of durable polymer or biodegradable polymer drug eluting stents for the outcome of death, although a strong trend existed towards reduction in death with cobalt chromium everolimus eluting stents compared with paclitaxel eluting stents (rate ratio 0.81, 0.66 to 1.00).
Bonferroni’s post hoc analysis, however, showed a strong trend but no significant effect of alcohol in reducing the number of new-born immature neurons as compared to the alcohol naïve controls (ns: p = 0.0684) and pindolol had no effect in this group (ns: p = 0.1076).
Furthermore, there was a strong trend that the difference between fleeing to heterospecific and conspecific alarm calls was larger when noise was played than not played (10 birds showed a greater reduction in response in noisy conditions compared to quiet conditions versus three the opposite, p = 0.092; electronic supplementary material, tables S1, S2). 4 .
Focusing on variation with diagnoses within each cortical region, there were significantly lower levels of PPIA , SNCA and NOL9 mRNA as well as a strong trend towards significantly lower levels of GAPDH in BA 8 and a trend to lower levels of SKP1 in BA 9 from subjects with schizophrenia compared to control (Fig. 2 ).
While not statistically significant, there also was a strong trend for higher CSF IL-6 levels in this relatively small sample of men with PTSD compared to trauma-exposed men without PTSD.
A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance.
Ramatroban therapy likewise showed a strong trend towards reducing the incidence of AAA and aortic diameter, in conjunction with adventitial inflammatory cell infiltration and elastin degradation (Supplementary Figure S4).
In fact, in this study, a strong trend towards increased anxiety was documented and CBD had no effect on persecutory ideation. 1.6 CBD Neuroprotection CBD’s anti-inflammatory and antioxidant properties may offer a new pharmacological approach for neuroprotection and a reduction in hippocampal volume loss [ 23 , 40 , 41 ].
Yet interestingly, although none of the differences between these two approaches were statistically significant, there was a strong trend toward the performance of the Cumulative Z-score approach being slightly superior to the total pixel count approach.
There was a strong trend towards better operative 30-day survival for AVR(b) in the late half of the period (99.4% (98.9%–99.9%) vs 98.7% (98.0%–99.4%)) and a significant 1-year survival improvement (98.4% (97.6%–99.3%) vs 96.4% (95.3%–97.5%)).
There was also a 23% increase in CD98 median fluorescence intensity (MFI) in CD4+CAR T cells ( online supplemental figure 10B ), with a strong trend towards enhanced CD25 MFI staining ( online supplemental figure 10C ).
QKI showed a strong trend toward reduced expression in the SZ versus HC lines (SZ 0.59 ± 0.09 vs.
Upfront letrozole treatment for 5 years, however, showed a strong trend towards superiority over starting with tamoxifen for 2 years and then switching to 3 years of letrozole treatment.
While there is a strong trend in adults to a higher portion of shoulder injuries, this is not found in adolescents.
The study observed a strong trend showing better growth performance between progeny zebrafish fed soybean meal diet that originated from broodstock exposed to soybean meal as opposed to progeny fish fed soybean meal diet that originated from fishmeal diet fed broodstock.
Discussion In the present study we found that the RyR2 QQ genotype seems to be associated with a strong trend towards increased susceptibility to life-threatening arrhythmias in patients receiving ICD therapy for primary and secondary prevention.
In the latent class analysis, in Profiles 1 and 2, where older participants are represented, we found a strong trend towards lower use of technology, lower ability to actively engage with digital services and the lowest levels of DHL and self-efficacy in using health digital services.
In conclusion, even though the neutralization of IFN-γ failed to restore bacterial clearance and to significantly reduce bacterial outgrowth in the respiratory tract of co-infected mice as predicted by the mathematical model, we observed a strong trend for a potential therapeutic benefit via reducing the bacterial burden in the airways of co-infected animals.
Water column TDOC was closely correlated with water column TDN (r = 0.92, p < 2.2e-16; Figure 2 ), while water column TDP exhibited a much weaker relationship with TDOC (r = 0.27, p = 8.0e-11; Figure 2 ).TDOC did not exhibit a strong trend across the season ( Figure S2 ).
Interrater reliability was also fairly high (ICC = 0.76), with a p value of .06 which suggests that the data show a strong trend toward this level of reliability, although statistical significance was not reached.
Reconnection Score In the porcine study, we observed a strong trend toward association between contact scores per section during ablation and reconnection at follow-up at the same section.
In fact, there was a strong trend toward lower odds of fracture nonunion in HIV-positive participants compared with HIV-negative participants, although this was in a small sample of 23 nonunions.
Similarly, AMPK‐deficient pathogenic Th17 cell and immunosuppressive Treg populations showed a strong trend toward reduction at 6 weeks after transfer (Figure S2 C).