Barely Significant
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“a strong trend”

5,726 sentences · 5,726 papers · 7,352 search hits before verification · confirmed specimen

Sighted at

p=0.077

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

We observed a strong trend towards decreased levels of NEDD8-conjugated proteins upon treatment with MLN4924, though only reaching statistical significance in TDP-43 G348C MNs (Isog Ctrl P = 0.0799; TDP-43 A382T P = 0.0705; TDP-43 G348C P = 0.0266 by one-way ANOVA with Sidak’s multiple comparisons test) (Fig. 6 c, f, Supplementary Fig.
In accordance with previous models and studies ( Birkness et al., 2007 ; Lin et al., 2007 ; Martinez et al., 2013 ; Singh and Goyal, 2013 ; Polena et al., 2016 ) we observed significantly greater secretion of IL-6 ( P = 0.005) and VEGF ( P = 0.039) in our infected granuloma layers (+BCG) when compared to our control layers containing uninfected MDMs in monoculture (−BCG); further, we observed a 5–17-fold increase in TNFα secretion in 3 out of 4 independent experiments under the same conditions and a strong trend toward greater TNFα secretion ( Figure 3 and Supplementary Figure 4 ).