“a strong trend”

4 Abuse and misuse Beyond the increase in deaths, studies note a strong trend towards the emergence of drug abuse with prescription opioids.

There is a strong trend towards standardization for the use of tubes that are free of chemical additives.

Nevertheless, there was a strong trend toward increased plasma KC and MIP-2 concentrations after burn wound infection that was potentiated by IL-15 SA treatment.

In addition, exploratory analysis showed that CBD dose also had a significant direct relationship with all-case AEs and a strong trend-level association with treatment-related AEs in RCTs using THC-CBD combination.

Fasting plasma glucose and insulin measured at the start of glucose tolerance testing (GTT) did not differ between genotypes ( Figure 4C ), although there was a strong trend for increased fasting plasma insulin concentrations in CD1d −/− mice, consistent with a trend to increased insulin resistance.

It is of special interest that in the parasagittal plane, a strong trend in distance from skin to hyoid bone was found, with a cut-off point of 1.28 cm, with a sensitivity of 58% and specificity of 70%, although not significant ( p = 0.0599).

Although we found a strong trend towards occupations within the area “natural sciences, geography and computer sciences” compared to the general population [ 23 ], adults with ASD cover a broad range of occupational areas.

Therapeutic isotopes In addition to traditional imaging isotopes, there is a strong trend towards the production of therapeutic isotopes, as evident by the large number of sessions and individual talks.

We were unable to illustrate a strong trend toward older decedents costing less than their younger counterparts.

As all analyses were regarded exploratory, a significance level of 5% was regarded as a strong trend and was followed up by pairwise comparison with appropriate tests dispending adjustments for multiple comparisons.

In SHR-positive BCs with PIK3CA-mutations, a strong trend for impaired RFI was observed (adjusted HR 1.64, 95% CI 0.958–2.807), whilst in SHR-negative BCs PIK3CA -mutations were insignificantly associated with improved RFI (adjusted HR 0.49; 95% CI 0.152–1.597).

As shown by Gatesy [17] , a strong trend toward reduced caudofemoral mass can be seen in the lineage leading to modern birds.

Notably, although not statistically significant, there was a strong trend for increased synaptic transmission within the Arc − population in mice receiving paired training, compared with the unpaired and naïve groups ( Figure 5b ).

Although the effect reported in the original paper was not significant, it did appear as a strong trend, at least for conditions with a task.

In a study of adherence to antidepressant medications among college students, Hammond et al [ 39 ] found that there was a strong trend suggesting that the use of a medication reminder app was beneficial in increasing antidepressant medication adherence.

There was a strong trend towards improved visual function, but this did not reach statistical significance due to marked variability of outcome.

On the other hand, there was a strong trend with RadScopal treatment with or without immunotherapy to increase CD4 + T-cells ( Figure 4 A) that were not Foxp3 + Tregs for most ( Figure 4 B).

Although the BA graphic shows a mean difference between the methods of only −0.31 units (95% CI: −1.10 at 0.48 ng/mL), it was observed a strong trend of IA to overestimate androstenedione values in comparison to LC-MS/MS when the mean of the two methods was increased, causing non-constant variation at all concentrations ( Fig. 4B ).

3 – 6 In addition, two randomized trials have addressed this topic: The TIMING trial randomized 888 patients with ischemic stroke to early initiation of anticoagulation with non-vitamin K dependent oral anticoagulants (NOACs) within 4 days compared to a start at 5–10 days and found a strong trend in favor of an early anticoagulation. 7 The ELAN trial randomized 2,013 participants with ischemic stroke and AF and also found numerical superiority of early anticoagulation over later anticoagulation. 8 Beyond the results of randomized trials, however, data from prospective registry studies are also necessary and important in order to reflect everyday clinical practice and to include patients who were not included in randomized trials.

At the protein level, I/R rats exhibited an increase in pro-GDF15 in the RZ and a strong trend in the IZ compared to sham rats after 24 h of reperfusion.

9p deletions were linked to features of aggressive breast cancer such as high-grade and a strong trend towards reduced survival was found.

Overall, there is a strong trend for the importance of PG in mediating cell separation, further underlining the role of pectin in the process as well.

Principal component analysis of relative metabolite abundance per cell revealed a strong trend across the 54 cell lines (PC1, 58.9% explained variance, Supplementary Fig. 2 ), which strongly correlates with cell line volumes derived from cell diameters measured in ref. 66 as well as with the herein determined adherent cell size area (Supplementary Fig. 2 , see Supplementary Note).

There was a strong trend toward increase at the ETC CI + CII state, indicative of maximal electron transport chain capacity; but this was not statistically significant ( p = 0.067).

21 , 22 In our entire cohort, the MLAM‐IV resulted in a strong trend toward a longer duration of freedom from AF.