Due to the failure to meet earlier endpoints, these renal outcomes were exploratory only in the two trials, but nevertheless both suggested a strong trend towards a protective effect with treatment, with 40% reduction in the CANVAS Program (HR 0.60; 95% CI 0.47–0.77) and 47% reduction in DECLARE-TIMI 58 (HR 0.53; 95% CI 0.43–0.66).
We observed a substantial increase in fat mass in male mice ( Figure 1E ), while female mice displayed a strong trend toward gaining visceral fat mass with age ( Figure 1F ).
A strong trend toward an adjuvant effect was also noted when the antigenic breadth of the plasma IgA response was evaluated, particularly when responses to 4 or more or 5 vaccine antigens were considered.
scavenger receptor leukocyte recruitment tumor endothelial cells liver cancer tumor microenviroment Mauritius Research Council 10.13039/501100011856 MR/R010013/1 Rosetrees Trust 10.13039/501100000833 Utilizing qPCR analysis, we have previously shown a strong trend for decreased SCARF1 mRNA expression in HCC tumor tissue compared to normal liver tissue ( 14 ); here, we corroborated this finding with publically-available RNA-sequencing data from The Cancer Genome Atlas (TGCA).
Using the EV-enriched fraction as our baseline, we found that HIV-1 virions were enriched in cholesterol esters, ceramides, hexosylceramides, lysophosphatidylcholine, lysophosphati-dylethanolamine, lysophosphatidylserine, phosphatidylethanol-amine, oxidized phosphatidylethanolamine, phosphatidylserine, and oxidized phosphatidylserine with a strong trend toward decreased sphingomyelins ( Fig. 5 A ).
The resequencing data and a strong trend in growth rate data pointed towards temperature-dependent adaption, with more parallel SNP changes at 30°C; however, these data were not supported by measures of competitive fitness.
In univariate analysis, it was determined that the pectoralis major muscle area increased significantly with good clinical outcome (difference between areas was approximately 25.6 cm 2 and difference between indices was 9.4 cm 2 /m 2 ) and the pectoralis minor cross-sectional area and index showed a strong trend (average area was 6.4 cm 2 and index was 1.82 cm 2 /m 2 higher) (Table- 1 ).
In a prospective cohort study of 309 Barrett's patients followed in the Seattle Barrett's Esophagus Project, a strong trend was observed, with a 5 cm difference in length associated with a 1.7-fold increase in cancer risk (95% CI, 0.8–3.8-fold), when patients with HGD at entrance were excluded 36 .
reported a strong trend towards the association of the CYP2B6 G516T variant with high blood propofol concentrations after a single bolus dose [ 26 ].
Collaboration Patterns and Strategic Gaps The study reveals a strong trend toward international collaboration, with a growing number of publications co-authored with researchers from around the world.
Furthermore, group PD-MED–DBS showed a strong trend towards more normalized values for the COP motion times and velocities in both leaning directions compared to group PD-MED.
Indeed, we also found a strong trend toward greater mother-daughter vaginal microbiota similarity (lower within pair θ YC distances) if the mother was in her reproductive stage rather than postmenopausal (Wilcoxon test p-value=0.07) ( Supplemental Figure 2 ). 3.4 Lactobacillus crispatus isolates from mother/daughter pair I have highly similar genome sequences The birth mode-dependent similarity of the vaginal microbiotas of mothers and their daughters suggested that vaginal bacteria could be transmitted between generations at birth and persist into adolescence.
Differences between NAWM and NWM V ax , D ax , and AD led to negative results though a strong trend was seen for V ax .
While this research generally is premised on the idea that mating behaviors should ultimately facilitate reproductive success of the individual engaging in the behavior ( Buss, 2003 ), a strong trend has moved toward appreciating nuance and variability in mating strategies across individuals (e.g., Buss and Schmitt, 1993 ; Gangestad and Simpson, 2000 ).
Further, significant portions of TRMs expand during murine PDAC progression and exhibit a pro-fibrotic transcriptional profile and a strong trend towards poor survival when mapped to human PDAC datasets.
PTEN -deletion PCa showed infrequent concurrent DACH1 deletions in 5 of the 6 cohorts (not all datasets are independent), with a strong trend toward mutual exclusivity (Supplementary Fig.
For contralateral tumors not directly exposed to BH, multi-variate statistical analysis of the modeled growth curves showed a strong trend toward growth control (Figure 1 F-G), with the AUC metric (Figure 1 H) yielding a significant reduction in integrated contralateral tumor burden.
While the intended timely sequencing of TT5 treatment segments was accomplished at acceptable toxicities (off study rate for toxicities, 12%), clinical outcomes were similar in TT5 and predecessor trials TT3a and TT3b, with a strong trend for inferiority for complete response durations despite comparable CR kinetics.
The ratio of hepatic UDP-Glc to UDP-Gal levels was increased in Gale TG livers, and the ratio of UDP-GlcNAc to UDP-GalNAc levels had a strong trend of being suppressed by Gale overexpression ( Fig. 1 G ), suggesting that GALE is enzymatically active in our mouse model.
The HO-diet provided more B12 to the liver than the CN-diet, and a strong trend to the higher accumulation of CN-B12 in the kidney as compared with HO-B12 was observed.
Although SP overexpression did not affect the average size of spine heads, the fraction of SP+ spines showed a strong trend towards an altered size distribution.
Notably, like 2-DG, there was also a strong trend for reduced expression of IL1B along with IL6 mRNA following addition of Eto ( Figure 2A ), although the reverse was seen in terms of secretion ( Supplementary Figure 3 ).
There is a strong trend for significant correlations of functional efficiency within each MUC1 variant class.
Figure 4i suggests that shorter carbonization time may allow for a broader range of capacitance values, but does not show a strong trend.
Rates of recurrent COPD hospitalisations For all years from 2017 onwards, there has been a strong trend in reduction of rates for recurrent COPD hospitalisations compared to 2015 (e.g., RR for 2022 vs. 2015 = 0.20 95% CI (0.16, 0.26)) see Table 5 .