“a slight trend”

We did detect a slight trend of higher pSmad2/3 signal in Tcf-1 + cells although it did not reach statistical significance ( Fig.

This finding indicates that although there is a slight trend toward a reverse influence, its effect is relatively weak compared to the significant impact of metabolic dysregulation on brain iron deposition and, consequently, on cognitive function (Table S5 ). 3.5.4.

There was a slight trend of increasing α-helical content with increased amino acid hydrophobicity (see Table S2 ), similar to results obtained for 1a − c .

Calculation and analysis revealed that the field of tumor immunotherapy shows a slight trend of polarization, and the immune checkpoint inhibitor PD1 blocker shows the greatest potential for future development.

Note that, for variable CYP3A4, the correlation looks weakly positive, so there was a slight trend of higher scores when it took the value of “yes”.

The correlation between age and anxiety was weak and non-significant (Pearson r = −0.10 with HADS-Anxiety, p = 0.20), indicating at most a slight trend toward higher anxiety in younger patients.

Furthermore, a slight trend of reduced recurrence was observed in OC patients with non-methylated KL.

A recent study (Bergh et al., 1995) shows that adjuvant therapy, especially with tamoxifen, along with radiotherapy seems to be of less value for breast cancer patients with TP53 mutations and node-positive tumours than patients without mutations. In conclusion our data show that it is possible to use archival material for TP53 mutation analysis and that results are comparable with those obtained from fresh tumour tissue. There was a slight trend towards poorer prognosis in overall and breast cancer corrected survival for patients with TP53 abnormalities.

Once again there was a slight trend for PTPN22 KO clones to cluster toward the higher range of peak calcium flux value, which likely accounts for the slightly steeper slope as they returned to baseline, but overall the variance was such that this difference was not statistically significant.

However, we note that a slight trend toward reduced replication by Vpr-deficient strains was evident from these studies, which may correlate with the observed trend toward slightly reduced infectivity and depletion by Vpr-deficient X4 virus.

A slight trend was observed indicating the mean age of the examined patients slightly increased with each year of measurement (see Figure A3 ).

Additionally, there was a slight trend toward an increased RER in the Adipoq‐F2‐KO mice, particularly during the light/resting period, where the RER approached 1.0, suggesting a preference for carbohydrate metabolism over fat (Figure 4g ).

While there is a slight trend to lower pressures in the samples with Fo < 75 in Haleakalā ( Fig. 4B ), there is not a strong correlation between Fo content and pressure.

46–49 In the IR group, serum insulin and HOMA-IR levels were observed to be elevated twofold; however, in the OB-IR group, these values were elevated almost fourfold compared to those of the NIR group, with a slight trend toward increased glucose levels.

There was a slight trend, but one that did not reach statistical significance, for increased total PDE4 activity in mice fed an HFD for 3 weeks vs. mice fed an ND (Supplementary Fig.

report that luteal phase OS is equally effective as follicular phase OS even if there is a slight trend for longer stimulations and a higher dose of total gonadotropin ( 24 ).

elegans , at the higher concentration (2.46%, C6) there is a slight trend to the decrease in n3 PUFA.

In contrast, the number of neutrophils does not seem to be affected by the presence of the developing tumour; despite a slight trend of increased neutrophil fluorescence in the cancer area we could not detect a statistical difference compared to a site that was not injected with cancer cells ( Fig 4 C, D and G).

Despite a slight trend towards increased CO after 30 minute reperfusion, the observed recovery in 3 month old hearts was not observed in 12 month old hearts ( Fig 5 ).

Moreover, regarding the treatment steps, a slight trend in the reduction in the mean HbA1c was seen in all pharmacological steps, the greatest seen with one or two NIAD starting in 2013, with a 0.3% reduction in both cases.

Action potential half-widths showed a slight trend toward lengthening ( Figure 3D ) and peak amplitudes a slight trend toward decreasing ( Figure 3E ) across the 100 and 200 Hz trains.

Within each method, there was little variation in the mean weight loss across age groups, although there was a slight trend toward greater weight loss being observed in the oldest age groups: mean weight loss for the trend method ranged from −5.2% (−5.7% to −4.7%) to −5.8% (−6% to −5.6%) across age groups and from −6.3% (−6.5% to −6.1%) to −10.2% (−10.3% to −10.1%) using the historic mean.

The results showed a slight trend of protection in the vaccinated group when compared to the control group.

Moreover, the DM MA has a slight trend of decreased number of junctions and segments compared to the EV MA , which may explain the lack of effect observed previously with the whole secretome.

Comparing the fraction of each patch occupied by stroma to adjacent wild-type groupings indicated a slight trend toward increased packing density for STAG2 − as well as KDM6A − crypts that failed to reach significance ( Figure 2 G ).