Overall, there was a slight trend that survival rate was higher in patients who received T-DXd treatment ≤2/>2 months after nivolumab therapy (HR [95% CI]: 0.79 [0.53–1.17]) compared with those who received T-DXd treatment ≤3/>3 months (HR [95% CI]: 0.87 [0.58–1.30]), ≤4/>4 months (HR [95% CI]: 0.97 [0.65–1.46]), and ≤5/>5 months (HR [95% CI]: 0.93 [0.62–1.40]) after nivolumab therapy ( Fig.
In miro1(tm1966); miro-2(tm2933) animals, there is a slight trend of fewer axonal mitochondria but the density is not significantly reduced compared to the control (Figure 1—figure supplement 1B), which is similar to the previous findings in touch receptor neurons (Sure et al., 2018).
A slight trend towards lower nephrotoxicity in patients with low AUC 24 was observed in Figure S4 .
Although there appears to be a slight trend toward faster processing in the presence of ubiquitin that correlates with the thermodynamic stability of the substrate folded domain, those effects are very minor and statistically insignificant.
Moreover, Ki-67 staining by immunohistochemistry revealed varying levels of proliferative activity within the CLL-like lymphomas, ranging from 5–50%, with a slight trend towards increased proportions of Ki-67 + cells when canonical NF-κB is activated (Figs. 4A and S4F ).
As can be seen in Figure 3 , only a slight trend of lower milk production was observed in the SPS system. 3.3.
Clinical trial findings on the OpHLINE ® series confirmed a favourable safety profile across all formulations The overall safety profile was favourable across all formulations although a slight trend of a concentration-dependent IOP spike trade-off was detected.
However, there was a slight trend towards larger immature moDCs.
There was a slight trend toward reduced bacterial burden in the C57BL/6 mice depleted of B cells ( Figure 2B ) as well as increased control in the spleens of B cell deficient mice ( Figure 1H ) [21] .
Additionally, there was a slight trend toward higher mortality risk during weekend hospital stays; however, the increase was insignificant, with a hazard ratio of 1.071 (95% confidence interval: 1.005–1.140, P = 0.03).
For LDAS, there was a slight trend towards better reflection of inhibition of structural damage (TS <0) with increasing sustainability of response.
The results found that the model without label smoothing performed better in terms of the training and validation accuracy; however, the model with label smoothing obtained a loss function value 17% lower, indicating a slight trend to generalize better.
Hypertension prevalence at each grade was fairly equal across age groups, although there was a slight trend towards increased grade 1/2 hypertension in patients aged <55 years.
The levels of pH, pO 2, and pCO 2 remained within healthy limits, but showed a slight trend towards under-perfusion towards the end of culture ( Supplementary Fig.1e ). 2.3.
There was also a slight trend over time for increased discharge (See Table 2 ).
While there was a slight trend towards enrichment for asparagine-, serine- and threonine-rich proteins, glutamine was the only polar amino acid found to be significantly enriched amongst the proteins differentially labeled by both MT Htt Q25 and MT mHtt Q103 (Fig. 7 ).
Nonetheless, there may be a slight trend toward an increase in the Young modulus [ 49 ].
However, the other bundle types also offer noise suppression, with a slight trend toward greater noise suppression for thicker bundles ( Figure S5 ).
The subgroup analysis did not show any statistical difference in survival except for a slight trend toward improved survival for patients with adenocarcinoma; these patients received chemotherapy for more than 90 days in the gefitinib 250 mg/day arm, suggesting a possible effect of gefitinib monotherapy as maintenance therapy.
Conversely, there was a slight trend towards increasing choroid plexus volumes, however not reaching significance.
Additionally, there was a slight trend among clones at the end of the incubation to be less similar to environmental sequences than clones prior to incubation (average similarities: t 0 = 98,9%; t end = 97,8%).
We did note a slight trend towards a latency of leukemia onset in HIF1 −/− animals but this did not reach significance and was also not noted in mice transplanted with ARNT −/− cells, in which HIF signaling is completely absent.
2A ), although a slight trend towards increased plasma H 2 O 2 levels was detected in old rats ( Fig. 2B ).
The spatial distribution exhibits a slight trend of expansion.
There is also a slight trend in the V imp distribution with different V r values ( Figure 4 f), similar to the BTO single-crystal sample.