“a significant trend”

Comparison of the staining patterns among patients revealed a significant trend towards increased frequency of DFS pattern (ANA associated diseases 10.4%, JIA 21.7% and nonrheumatic conditions 34.8%, p < 0.0001) and decreased frequency of homogenous staining (ANA associated diseases 34.3%, JIA 26.7% and nonrheumatic conditions 8.9%, p < 0.0001) in nonrheumatic conditions.

The incidence of reaction around the depot was significantly increased in eyes with larger pored particles and there was a significant trend for higher incidence of vitreous reaction with larger pores (10 nm: 0%, 30 nm: 29%, 50 nm: 71%, 100 nm: 100%, p < .0001, Cochran Armitage Trend Test).

Among the four primary tumor types described, we observed a significant trend toward improved cPFS with anti-PD1+anti-CTLA4 ICI versus anti-PD1 alone in mucosal melanoma (p=0.0001, figure 4C ).

In model 1, the ORs and 95 % (CIs) were 1.38 (1.02, 1.85), 1.73 (1.31, 2.27), and 2.93 (2.29, 3.76), respectively, with a significant trend (p < 0.0001).

There was a significant trend toward better OS for early-stage patients in the entire cohort and in the CCRT group (P <0.0001 and <0.036, respectively).

Exclusion of SNPs showing a significant trend (with p<0.0001) reduced the set further to 5609 SNPs.

Simple linear regression on age shows a significant trend towards an increase in the number of TTV genotypes detected in sera as a function of age ( p value < 0.0001; R 2 = 0.02039) ( Figure 4 d).

There was a significant trend ( p < 0.0001) in increasing seroprevalence by quartiles of lead (Table 3 ).

There was a significant trend of increased methylation with disease grade comparing normal to CIN1 and CIN3 ( p < 0.0001).

The profiles of IgG in urine in the curative treatment group showed a significant trend of decline with time post-treatment (Kruskal-Wallis test = 113.4–212.6, p value < 0.0001) and the lowest levels were seen 12 months post-treatment.

Considering the severity of MetS in terms of total score, we found a significant trend in association with the risk of FIT-positive (online supplementary figure 1a , p<0.0001 in trend test).

3 , Kaplan Meier curves showed a significant trend of decreasing survival in the hypertensive population with increasing whole-blood lead levels (All Log-rank P < 0.0001).

A more recent analysis for NHANES 2007–2010 data found a significant trend ( P < 0.0001) toward higher HEI 2010 scores for children who consumed 12 oz of juice/d (HEI = 52.3) than those who did not consume juice (HEI = 43.8) ( 40 ) There are reports that argue fruit juice consumption is comparable with consuming sugar-sweetened beverages that contribute to overweight and obesity, particularly among children ( 41 – 43 ).

For the five oceans under investigation a significant trend was found (p<0.0001, significance level of 0.05).

CKD Stage and Cardiac Biomarkers Concentrations There was a significant trend toward increasing plasma NT-proBNP (P < 0.0001), serum cTnT (P = 0.002), and spot urine albumin creatinine ratio (P < 0.0001) concentrations with declining estimated GFR (eGFR).

There was a significant trend ( P < .0001) for ORs for moderate and poor SCF associated with institutional racism as reported in 1997, based on the domains of housing, jobs, and police.

In HEK293 cells with β-arrestin knocked out, there was a significant trend towards increasing the potency when β-arrestins were knocked out ( p < 0.0001) ( Figure 4B , Supplementary Table S6 ).

Primary outcome The primary outcome of change in FMD of the brachial artery showed a significant trend in the difference among arms from TC to EC-nicotine to EC-nicotine-free (linear trend β for TC, EC-nicotine, EC-nicotine-free = 0.73%; 95% CI: 0.41 to 1.05; p < 0.0001).

A significant trend was noted for PTB and decreasing maternal age (χ 2 = 14.79, p = 0.0001), but no trend was noted for LBW (χ 2 = 0.36, p = 0.55) and maternal age.

The serum IL1α levels were similar for both groups when the comparison was performed using a Tukey’s test ( p = 0.778); however, the linear test for trend indicated a significant trend ( p = 0.0001).

Also, a significant trend of risk reduction associated with increasing duration of use was reported ( p < 0.0001) in this study.

The highest VAT/SAT values (0.94, 1.00, 1.01, 1.26) were seen in Japanese Americans with a significant trend ( P < 0.0001).

There was a significant trend towards a decrease in average ED LOS 282 (standard error of mean [SEM] ± 19) vs 185 (± 13) minutes ( p = 0.0001).

Irrespective of the equation applied for the derivation of eGFR and subsesquently the CKD grade, all HRs were significant, lower than unity for CKD grade 1 and greater than unity for CKD grade ≥3 with a significant trend p value from stage 1 to ≥3 ( p < 0.0001) and without any racial difference (0.11≤ p ≤ 0.98).

However, there was a significant trend towards poorer image quality in older patients (>75 yrs vs. <45 yrs; p < 0.0001).