“a significant trend”

Thus, there was a significant trend for increased body weight with higher levels of sPD-L1 (trend test, P < 0.0001) and a moderate Spearman's rho (0.24, P < 0.0001) ( Supplementary Figure 1 ).

There was a significant trend ( P < 0.0001) for progression of hepatic disease from fibrosis to cirrhosis and eventually to HCC with increasing age ( P < 0.0001).

A significant trend was noted for PTB and decreasing maternal age (χ 2 = 14.79, p = 0.0001), but no trend was noted for LBW (χ 2 = 0.36, p = 0.55) and maternal age.

There was a significant trend of more recent utilisation of DOACs compared with warfarin (p<0.0001).

After excluding deaths within two years, the DM −/HP + and DM +/HP − groups demonstrated elevated risks of all-cause mortality compared to the DM −/HP − group in the crude model, with respective HRs of 1.32 (95%CI 1.13–1.55), 3.30 (95%CI 2.67–4.07), and 3.54 (95%CI 2.78–4.52), and a significant trend (p < 0.0001).After full adjustment, the DM −/HP + and DM +/HP − groups exhibited increased risks of all-cause mortality compared to the DM −/HP − group, with respective HRs of 1.09 (95%CI 0.93–1.27), 1.30 (95%CI 1.04–1.63), and 1.35 (95%CI 1.05–1.74), with a significant trend (p = 0.01).

For all the kits tested, there was a significant trend of increasing methylation levels with a severity of the disease (Cuzick tests for trend, p < 0.0001, Figure 6 .).

There was a significant trend ( P < .0001) for ORs for moderate and poor SCF associated with institutional racism as reported in 1997, based on the domains of housing, jobs, and police.

There was a significant trend for association between serum BC and reported total fat intakes ( r = −0.002, p < 0.0001), but the association was not strong.

One-way ANOVA exhibited a significant trend ( P < 0.0001) between the control and 8 Gy of radiation.

Primary outcome The primary outcome of change in FMD of the brachial artery showed a significant trend in the difference among arms from TC to EC-nicotine to EC-nicotine-free (linear trend β for TC, EC-nicotine, EC-nicotine-free = 0.73%; 95% CI: 0.41 to 1.05; p < 0.0001).

Analyses of tumour characteristics by year of diagnosis showed a significant trend towards lower risk tumours in more recent years, driven by a highly significant trend towards lower nodal status (p<0·0001 for both oestrogen receptor-positive and oestrogen receptor-negative groups; table 1 ; appendix p 35 ).

The serum IL1α levels were similar for both groups when the comparison was performed using a Tukey’s test ( p = 0.778); however, the linear test for trend indicated a significant trend ( p = 0.0001).

For the five oceans under investigation a significant trend was found (p<0.0001, significance level of 0.05).

A more recent analysis for NHANES 2007–2010 data found a significant trend ( P < 0.0001) toward higher HEI 2010 scores for children who consumed 12 oz of juice/d (HEI = 52.3) than those who did not consume juice (HEI = 43.8) ( 40 ) There are reports that argue fruit juice consumption is comparable with consuming sugar-sweetened beverages that contribute to overweight and obesity, particularly among children ( 41 – 43 ).

Among the four primary tumor types described, we observed a significant trend toward improved cPFS with anti-PD1+anti-CTLA4 ICI versus anti-PD1 alone in mucosal melanoma (p=0.0001, figure 4C ).

This analysis revealed an over time decrease in the mean dissimilarity, which was significant between the day of discharge with the 2-month ( P < 0.001) and 4-month samples ( P < 0.0001), and a significant trend over time ( P < 0.0001).

There was a significant trend towards outpatient treatment over the study period ( p < 0.0001).

There was a significant trend towards a decrease in average ED LOS 282 (standard error of mean [SEM] ± 19) vs 185 (± 13) minutes ( p = 0.0001).

Over the decades, a significant trend in increasing the mean age of mothers (25%) and their partners (24%) (p<0.0001) was observed ( online supplemental Figure 1 ).

A significant trend toward higher ST2 values with age was also observed, but for males only (r = 0.43, p < 0.0001).

However, there was a significant trend towards poorer image quality in older patients (>75 yrs vs. <45 yrs; p < 0.0001).

The highest VAT/SAT values (0.94, 1.00, 1.01, 1.26) were seen in Japanese Americans with a significant trend ( P < 0.0001).

In HEK293 cells with β-arrestin knocked out, there was a significant trend towards increasing the potency when β-arrestins were knocked out ( p < 0.0001) ( Figure 4B , Supplementary Table S6 ).

Utilizing bc-GenExMiner v4.0 36 , 37 , we found a significant trend in DEAR1 mRNA downregulation in basal-like tumors compared to other subtypes (p < 0.0001, Supplementary Fig.

There was a significant trend for RAMP3 to increase maximal signaling in response to all agonists ( p < 0.0001) ( Fig. 2 , E and F , Table 1 ).