“a significant trend”

Although bladder cancer has historically occurred with a 3:1 male predominance, we are observing a demographic shift: a 1% annual decrease in male incidence in many parts of Europe, along with a significant trend toward earlier diagnosis in patients under 50 years old (hazard ratio [HR] 1.34, 95% CI 0.6–2.07, P = 0.003) ( 2 ).

In men, a significant trend of ORs in each quintile was found (p = 0.003).

Lipocalin-2 levels were higher in HIV-infected subjects (+53%; p = 0.007), with a significant trend ( p = 0.003) for higher levels among subjects taking NNRTIs.

Notably, a significant trend was observed across the different CAR categories ( P = 0.003; Table 2 ).

There was no significant difference between F IS and F e in short-lived species (16 cases with F IS < F e , compared to 10 with F IS > F e , P = 0.33), in contrast to herbaceous perennial species that present a marginally significant trend (23 cases with F IS < F e , compared to 11 with F IS > F e , P = 0.057) and woody species that present a significant trend (55 cases with F IS < F e , compared to 27 with F IS > F e , P = 0.003).

Stratifying females by obesity status, a significant trend across CRF quartiles for PCS was observed for both obese (p = 0.003) and non-obese (p = 0.001) groups after adjusting for potential covariates.

However, meta-regression of studies arranged by initiation year revealed a significant trend toward a decreased MD with more recent surgeries ( P = 0.003).

Looking specifically at line of advanced disease therapy, there was a significant trend to longer PFS ( p = 0.0031 ) and OS ( p = 0.0002 ) for patients receiving nal-IRI + 5-FU/LV in earlier lines of therapy, compared with later (Fig. 2 ).

We tested whether the proportion of positive and negative correlations were equal across a range of correlation thresholds; and we observed enrichment of positive correlations with a significant trend ( P = 0.0031) for increasing r thresholds (Figure 5B ).

On the other hand, LoF carriers were more likely to have a family history of breast cancer than non-carriers (OR 3.94, 95% CI: 1.07–18.10, P =0.023) and there was also a significant trend with the increase in the total number of breast cancer cases within a family ( P =0.0035).

2c ; Dunnett’s multiple comparison test, p = 0.01, N = 9) and there was a significant trend of decreasing IOP noted over the 12-month period (Fig. 2d ; simple linear regression, p = 0.0036) with a reduction in IOP of 21.88% from baseline to 12 months.

In one study, this delay in culture conversion was dose-dependent [ 42 ], with a significant trend of increasing AOR ( p = 0.004) with greater smoking, rising to an AOR of 11.6 and 95% CI 1.8–73.4 in those smoking more than 20 cigarettes a day.

And we also observed a significant trend of shortened survival in patients in the PC subgroup ( Figure 1(c) , log-rank test p = 0.004).

Primary and secondary care diagnostic intervals and stage of CRC For the combined cohort, we observed a significant trend for a concave, ∩-shaped association with increasing and subsequently decreasing odds of advanced CRC with longer primary care intervals ( P =0.004).

Persistent cough after 2-week ICS treatment showed a significant trend to increase as past duration of cough, reported as baseline, increased (linear trend analysis, p = 0.004) ( Fig. 2 ).

In addition, at the 20-year follow-up, we observed a significant trend of de novo overactive bladder occurrence in 15 out of the 36 patients [(41.6%) ( p = 0.004)].

Using the proportional hazard wall thickness as a continuous variable demonstrated a significant trend of increasing risk of hard events (p = 0.004) and any events (p = 0.001) with increasing LV EDWT.

A significant trend across incidence quintiles was observed between prevalence figures for all treated chronic illnesses and for treated diabetes (p = 0.004 and p<10 −4, respectively), the proportion of the population living in rural areas (p<10 −4 ), the unemployment rate (p<10 −4 ), the FDep index (p = 0.02), the LP

When the number of CVRFs was treated as a continuous variable, a significant trend of increased OS risk was observed in the chemotherapy subgroup (HR =1.32; 95% CI: 1.09–1.58; P=0.004), and a similar (though not statistically significant) trend was noted in the radiotherapy subgroup (HR =1.23; 95% CI: 0.98–1.53; P=0.08) ( Table 4 ).

There was a significant trend overall for HOMA IR to increase with increasing BMI, waist circumference and percentage body fat (all p <0.004, Table S3 ).

However, there was a significant trend toward an increased incidence of AOM with a tympanic bulge by Veau classification ( p = .004).

Chi-square analysis indicated a significant trend of increasing mortality as fluids per kg increased, p = 0.004.

However, there’s a marginally significant trend for gender ( p = 0.053) and a significant trend for drinking status ( p = 0.004), suggesting that the effect of social activities might vary more substantially across these categories.

A significant trend of higher percentages of complications of any OF was noticed in subsequent AD/ACLF IND , compared with that in subsequent AD/ACLF BAC ( P = 0.004, Fig 4B ).

No significant trends were seen between chickenpox infection and housing deprivation score or social class at age 5 years, although a significant trend was seen between chicken pox infection and social class at birth (decreasing risk with more affluent economic status, p = 0.004).