“a significant trend”

A significant trend was observed across quartiles in all models ( P for trend < .001 in Models 1 and 2 and P = .003 in Model 3), indicating a dose–response relationship.

Further, the continuous monotonic relationship between ln (α-Klotho) and final eGFR was formally significant (rho = 0.28, P = 0.002; Figure 2C ), and the distribution of α-Klotho tertiles across KDIGO stages also supported a significant trend association (P = 0.003; Figure 2D ).

There was a general trend towards those with more severe levels of intellectual disability being more sedentary and less physically active, however, ANCOVA adjusted for confounding variables only found a significant trend towards a decreasing number of steps per day as the level of intellectual disability becomes more severe [ F (2, 145) = 6.2, p = .003].

In the 25(OH)D3 quartile subgroup analysis, compared with the Q1 group, the Q3 (OR = 0.35, P = 0.034) and Q4 (OR = 0.25, P = 0.004) groups showed significantly lower odds of cognitive impairment, with a significant trend (P = 0.003).

Figure 3 shows how study designs and analytical methods evolved over time with a significant trend of increasing use of ITS regression analysis ( P = 0.003).

Moreover, a significant trend (p = 0.003) in fluconazole use during the whole time period considered emerged, particularly in the ICU (p = 0.017), but also in the general medicine wards (p = 0.03).

Figure 2 shows Kaplan-Meier curves of the proportions of subjects remaining in sinus rhythm in the 3 groups, which revealed that there was a significant trend toward an increased risk of AF recurrence in the group with higher GRS (log-rank test; p=0.003).

3 ) with an OR of 1·54 (95 % CI 1·12, 2·12; P =0·008) between the top and bottom quintile and a significant trend ( P =0·003) across quintiles.

Trend tests showed a significant trend for informal social support ( P = 0.003).

Summary of main findings Over eight and a half years, there was a significant trend toward increased positivity for cannabis over time, which was significant for the 25–64-year age group (from 16.6% to 22.4%, linear association p = 0.003).

Conversely, there was a significant trend of studies with larger sampling errors reporting higher cure rates ( P = 0.003).

We also observed a significant trend in sentiment across all users (β=–.02; P =.003), with users increasingly using more negative language as they continued to interact with the community.

Moreover, the frequency of positives from NAG to premalignant lesion and to intestinal-type GC showed a significant trend ( P =0.003).

While there was no significant association between DCA and mean annual percent change in Trails A test score when treated as a continuous and for each of the 4 quartiles, there was a significant trend across quartiles in the fully adjusted model ( P = 0.003).

A significant trend towards a prolonged time to CNS relapse following intravenous rituximab treatment was observed (P=0.003; Fig. 4 ), but neither intravenous HD-MTX nor intrathecal injection reduced the incidence of CNS recurrence (P=0.689 and P=0.876, respectively).

There was a significant difference between CS and any culture positivity with p = 0.011 and there was a significant trend between increasing CS and culture positivity with p < 0.003.

Lipocalin-2 levels were higher in HIV-infected subjects (+53%; p = 0.007), with a significant trend ( p = 0.003) for higher levels among subjects taking NNRTIs.

In the fully adjusted model (Model 3), compared to the first quartile, individuals in the highest quartile of OBS exhibited a negative association with 10-years ASCVD (OR: 0.59, 95% CI: 0.42–0.83, p = .002), with a significant trend ( p = .003).

A significant trend in SI-related ED visits was found by year (odds ratio = 1.12, p = .003) when adjusting for maltreatment type and demographic characteristics.

We observed a significant trend in better ORR to ICI according to the DDR-GA status: 1/11 (9%) patients in UPa, 5/17 (29.4%) patients in PPa, and 9/20 (45%) patients in Pa ( P = .003, Cochran-Armitage trend test), and an increased 6-month PFS probability of 11%, 44%, and 50% in the UPa, PPa, and Pa groups, respectively ( P = .37, log-rank test).

Hypertension was by far the most common comorbid condition (48.6% of all patients) and showed a significant trend towards increasing prevalence in higher EHRA classes ( P = 0.003).

Stratifying females by obesity status, a significant trend across CRF quartiles for PCS was observed for both obese (p = 0.003) and non-obese (p = 0.001) groups after adjusting for potential covariates.

A significant trend ( p = 0.003) was observed that highlighted the relationship between the ropivacaine dose and the incidence of breakthrough pain.

Although the antihypertensive treatment with the use of 2800 IU daily was not effective, a significant trend of an inverse association between the achieved 25(OH)D concentration and systolic pressure was noted ( p = 0.003).

In men, a significant trend of ORs in each quintile was found (p = 0.003).