“a significant trend”

They reported a significant trend toward continuing decline in macular thickness during the 3 years after operation (reduction from 499.1 ± 174.9 μm to 219.4 ± 66.6 μm).

rubella , even though there is a significant trend in the other diversity statistics ( Figure 2 ).

In a large cohort study, Karlson et al found a decreased risk of RA among women who breast fed for more than 12 months, with a significant trend with increased duration of BF. 15 Restricting the analyses to RF positive patients, a similar reduction was found for a total BF duration of ≥24 months.

While these findings, along with our results, imply a significant trend, a prospective clinical study is necessary to establish a more robust conclusion. 5.

There was a significant trend in the probability of remaining free from CVD across the quartiles of greenspace (p = <0.001) ( Fig 1B ); the probability of remaining free from CVD amongst those in the greenest areas was 4.5% higher than those in the least green at age 80, a figure that dropped to 0.9% at age 90.

31 Emphasising the latter point, some investigators have averred that improved longevity and population growth are leading to increasing proportions and numbers of older people, with age-related diseases emerging as a significant trend in many parts of the world. 32 33 Regardless, rapid transitions in social–cultural and economic structures and accompanying, nutrition and life styles imbalances do not seem to explain much in this setting.

both the benign nodule and the control group, with a significant trend of increasing plasma 8-isoprostane levels from pulmonary controls to subjects with lung benign nodules to subjects with lung cancer.

After mutual adjustment (model 3) the strength of the association with male gender increased (OR = 1.65) and there was a gradual increase in risk with increasing Townsend score across all quintiles with evidence of a significant trend.

And we observe a significant trend towards increased [ 18 F]FDG uptake in osteolytic lesions relative to osteoblastic metastases, which is consistent with prior studies ( 34 ).

In our small observational cohort, we observed a significant trend towards higher white cell counts and neutrophil counts in patients with dyslipidaemia.

Their increasingly frequent application highlights a significant trend toward the adoption of advanced technologies and artificial intelligence within the field of scientific and psychological research.

Moreover, AI-driven automated diagnostics have become a significant trend ( Kale et al., 2024 ).

UREA levels did not show a significant trend, whereas Cr levels were negatively correlated with concurrent AC exposure.

Procedure duration did not exhibit a significant trend throughout the observation period, with values of 342.1 ± 138.0 days in 2015 and 397.0 ± 130.3 days in 2024 (+16.1%), and limited variation around a mean of 357.0 ± 32.2 days ( Supplementary Figure S1 B, available at https://doi.org/10.1016/j.esmoop.2026.107732 ).

The number of green leaves of the tested varieties overall showed a significant trend of increase followed by decrease ( Figure 1 D), peaking at the flowering stage.

A linear-by-linear association test showed a significant trend between DHTL level and perceived usefulness of mobile application knowledge, with higher DHTL scores associated with greater perceived usefulness (χ 2 (1) = 15.04, p < 0.001).

A study demonstrated a significant trend wherein LDL-C is negatively associated with all-cause mortality, i.e., low LDL-C is associated with high mortality risk [ 48 , 49 , 50 ].

General anesthesia itself showed a significant trend of increasing the risk of direct esophageal injury. 20 – 21 A strong relationship between an esophageal temperature rise and pain has been shown by prior study. 22 Use of a proton pump inhibitor might facilitate ulcer healing and prevent the progression from esophageal injury to an atrioesophageal fistula. 23 – 24 In contrast, PNI was observed in 7.9% of the patients during the period when 25 to 30 W were applied to the posterior LA, suggesting that the periesophageal vagal nervous system was much more fragile than the esophagus itself to thermal injury.

In recent years, machine learning has become a significant trend.

These data indicate that SWS cycle durations for consecutive SWS cycles in controls showed a significant trend in decline that was lost in RTT ( Fig 2A ).

Given its small number, there is a significant trend of managing the disease alone, leading to a high risk of adverse outcomes and an increase in the prevalence of underdiagnosed cases of SCAD secondary to CTDs.

We noticed a significant trend in pAKT protein toward sustained increases in basal Snrk siRNA cells and further increase in Ang II–treated Snrk siRNA cells (Figure 3 A and 3 B).

In the fully adjusted model (Model 3), the odds ratios were 0.345 (95% CI: 0.211–0.565) for Q2, 0.126 (95% CI: 0.071–0.223) for Q3, and 0.126 (95% CI: 0.065–0.241) for Q4, with a significant trend observed across quartiles (P for trend < 0.0001; Table 2 ).

In our investigation into the interactive effects of multiple factors on the temporal impact of drought, we consistently noted a significant trend: with all fifteen combinations of dual-factor interactions contribute substantially to the enhanced explanatory capacity of the dependent variable.

As a result, these advantages (illustrated in Figure 2 ) give hope that, in the following years, there will be a significant trend toward the creation, improvement, pre-clinical and clinical testing of protocols for the nanotechnology-mediated delivery of miRNA-drugs. 3 Emerging applications of nanotechnologies for miRNA-mediated cancer therapeutics 3.1 Breast cancer Breast cancer is a heterogeneous disease distinguished by the growth of malignant tumors in mammary glands ( Heer et al., 2020 ).