“a significant trend”

In addition, a significant trend in mean BBPS score correlating with excellent, good, fair, poor, or unsatisfactory, as separately scored by the raters, was observed ( P < 0.001 for trend).

There was a significant trend for higher CD3 + and γδ IEL densities in higher degrees of morphological damage (Marsh–Oberhuber types 3a-3c) ( p = 0.001 by ANOVA, Fig. 4 ).

Further, the number of sickle-shaped blood vessels was associated with distant metastasis and OS, with a significant trend toward a poor prognosis (metastasis P < 0.001, Cox; OS P < 0.001, Cox) observed for patients with more than 100 such vessels in large maximal tumor sections.

Compared with controls, mean IGFBP-2 SDS were significantly elevated in patients with Dukes B ( P < 0.001), Dukes C ( n = 13 P < 0.001) and advanced disease ( n = 42 P < 0.0001), with a significant trend from early to advanced disease (one-way ANOVA P < 0.001).

This association was rather slightly intensified after adjusting for age and sex, and other possible confounders, and a significant trend ( P < 0.001) was maintained.

Treatment with slowly eliminated antimalarials was associated with a significant trend to decreasing risk of P. vivax infection recurrence up to 63 days after both malaria due to P. falciparum monoinfection and malaria due to mixed infection ( P < .001 for trend in both cases; Figure 2 ).

There was a significant trend towards increase in the proportion of school-children with NSLBP as age increased despite some inconsistencies at some ages [ X 2 for linear trend = 73.3, p < 0.001] (Figure 2 ).

The Jonckheere-Terpstra test showed a significant trend across 4 pain response categories in patients with PBMs and those with PNTs ( P < .001 for both).

A significant trend was observed between age and knowledge levels; participants who belonged to older age groups had more knowledge than the younger participants [ P -value < 0.001, Table 2 ].

LV and RV volumes, function and LV mass (age-related differences) All LV and RV volumes showed significant differences between age groups with a significant trend for an age-depended decline (all p < 0.001).

Metastatic Sites All phase 2 or 3 clinical trials showed a significant trend over time ( P = 0.001) of increasing proportions of patients with non-osseous metastasis (lymph node, visceral, and soft tissue) (1.4% per year increase), with stable proportion of liver involvement [ 22 ].

In addition, the relation between professional titles and competency scores showed a significant trend with higher professional title ( P <0.001, Table 4 ).

The prevalence of DM decreased consistently with the number of HLFs for all age groups with a significant trend ( P < 0.001) (Fig. 1 ).

The P values are indicated for the lowest dose with a significant effect (indicated by a single asterisk [*]) and curves with a significant trend (indicated by a pound sign [#]). ###, P < 0.001; # or *, P < 0.05.

For WC-defined phenotypes, both obesity and metabolic dysfunction independently contributed to increased CVD risk relative to MHN: MHO (RR 1.84, 95% CI: 1.23–2.77), MUN (RR 1.58, 95% CI: 1.14–2.20), and MUO (RR 2.22, 95% CI: 1.63–3.04), with a significant trend across categories ( P < 0.001).

In the echocardiographic parameters, a significant trend was observed: the left atrial anteroposterior diameter increased from the low-risk group (40 mm) to the high-risk group (45 mm) ( P < 0.001), and LVEF decreased across risk categories, with a median of 45% in the low-risk group, 40% in the medium-risk group, and 35% in the high-risk group ( P < 0.001).

affected by pruritus had been significantly reduced after treatment; duration − 1.5 (95% CI − 1.7, − 1.3; p < 0.001), indicating that patients transitioned from being bothered by pruritus for up to 18 h per day to a maximum of 6–12 h per day; degree − 1.3 (95% CI − 1.4, − 1.1; p < 0.001), implying a significant trend from moderate/severe to mild pruritus; and direction − 1.7 (95% CI − 1.9, − 1.6; p < 0.001), indicating a significant improvement in pruritus when compared with baseline (Table 2 ).

A significant trend ( P <.001) of increase in sharing of glass/bottle during training was observed.

Most features did not follow a significant trend over decades, except for the more advanced age at diagnosis and better performance status in decade 4 ( P < 0.001).

Among men, a significant trend was found, both with regard to individuals without hypothyroidism ( p < 0.001), and with hypothyroidism and levothyroxine treatment ( p = 0.021), while no such association was found among women.

In all groups, the proportion of bone in the fusion mass steadily increased over time in a significant trend ( P < 0.001), leading up to over 55% of bone after 26 weeks.

A significant trend was observed in the fully adjusted model ( P < 0.001).

In the stratified analysis, the risk was higher in each subsequent quartile, with a significantly higher risk in the fourth quartile in comparison to the lowest quartile (HR 1.59, 95% CI 1.37–1.86), with a significant trend over the quartiles ( P -value < 0.001, see Table 2 ).

Meanwhile, targeting VEGFR drugs had a significant trend of decreasing PDR compared with the control arms (OR 0.45, 95% CI (0.34, 0.59), P < 0.001, Figure 5 ).

Regarding the rate of decrease in antibody titres, there was a significant trend towards a decrease in the successful eradication group (p<0.001), but not in the unsuccessful eradication group (p=0.0550).