“a significant trend”

Results There was a significant trend toward greater intensity of chronic histology changes along the KDRI quartiles (χ 2 = 20.8; P < .001), including interstitial fibrosis, tubular atrophy, mesangial matrix increase and arteriolar hyalinosis.

For WC-defined phenotypes, both obesity and metabolic dysfunction independently contributed to increased CVD risk relative to MHN: MHO (RR 1.84, 95% CI: 1.23–2.77), MUN (RR 1.58, 95% CI: 1.14–2.20), and MUO (RR 2.22, 95% CI: 1.63–3.04), with a significant trend across categories ( P < 0.001).

However, after 16 weeks of co-administration of the drugs, blood glucose of mice was significantly reduced ( p < 0.01, p < 0.05), and blood glucose of the Met group showed a significant trend of reduction ( p < 0.001) ( Figure 1C ); the administration did not affect the body weight of db/db mice ( Figure 1D ).

Autochthonous Malaria trends in Spain throughout the 20th Century After applying the Mann-Kendall-Test for the trends of the annual number of cases for the malaria mortality in Spain (1900–1959) we have found a significant trend ( n = 59, p < 0.001, slope ( Q ) = −50.8).

Multivariate analysis demonstrated a significant trend change in HFMD reinfection following EV-A71 vaccination ( P < 0.001) ( Table 3 ).

For both incident and progressive CKD, there was also a significant trend ( P < 0.001 for linear trend) with more severe and longer AKI in multivariable analyses ( Supplementary Appendices S2 and S3 ).

Also, after 24 h exposure in the absence of metabolic activation, the frequency of binucleated cells with micronuclei was reported to be significantly elevated at all concentrations ( p < 0.05 for the lowest concentration tested; p < 0.001 all subsequent concentrations) with a significant trend test ( p < 0.001).

Comparing the ALS‐IPS with clinically derived stages based on the King's College system in all ALS subjects reveals a significant trend ( p = 0.001) of higher ALS‐IPS in progressive King's College stages (Figure 3B ).

The ES-J also differentiated healthy respondents (i.e., those with no history of MDE and without psychological distress) from subjects with a history of MDE and moderate to severe symptoms of psychological distress ( p < 0.001). The Jonckheere trend test revealed a significant trend ( p < 0.001): a healthy population without history scored higher on ES-J, and a severely distressed population with history scored lower on ES-J.

There was a significant trend change in DDDs for clopidogrel in 2010 ( p < 0.001), for prasugrel in 2017 ( p < 0.001), for ASA in 2015 ( p < 0.001) and for DOACs in 2012 ( p = 0.017).

There is a significant trend towards increased risk of undetermined suicide for every additional substance used apart from alcohol (OR = 1.63 for each substance – CI:1.22–2.17, P < 0.001).

Compared with the lowest quartile, higher Klotho quartiles were associated with reduced risk, with a significant trend across quartiles ( p < 0.001).

There was a significant trend in the association between duration of hypertension and VaD ( p < 0.001).

Eighty-eight individuals were newly identified as having PAD, and a significant trend of prevalence with increasing age was observed ( p < 0.001).

Interestingly, the gut microbial community showed a significant trend (ANOSIM test, P < 0.001) of return toward baseline conditions after the discontinuation of fasting ( Figure 2C ).

After adjusting for the effects of potential confounding factors such as age, sex, hypertension, duration of diabetes, biochemical data, and cataract status, a significant trend was observed for all contrast conditions ( p for trend p < 0.001).

Of those prepared to prescribe/explain to patients, 91% would also prescribe/explain to family/friends: a significant trend response (Chi-Squared for Trend, p < 0.001, data not shown) such that their response to one would reliably determine the other.

Patients with high ULK1 expression also displayed a significant trend toward worse survival compared with patients with low ULK1 expression (HR = 4.206, 95%CI (2.875–6.153) P<0.001, Table 2 ).

There is a significant trend for increased average oocyst intensity with increased infection prevalence ( p <0.001, r 2 =0.36), and this effect is also the same for all population groups individually ( A. arabiensis p =0.020, A. gambiae M form p =0.002, A. gambiae S form p =0.085).

More than half of the participants responded “definitely true” (22/121, 18.2%) or “mostly true” (45/121, 37.2%) to the statement: “I learned helpful information when I used the online community forum.” There was a significant trend for decreasing use of the online community forum by month of study ( P <.001).

In multivariate analysis, ECOG > 2 (HR = 5.21, p = 0.009) and lymphocyte percentage > 15% (HR = 0.08, p < 0.001) ( Figure 3 ) were independent predictors, and D-dimer > 0.65 μg/mL showed a significant trend (HR = 5.10, p < 0.001) ( Table 7 ).

In the postimplementation period, there was a significant trend difference between the intervention and control areas in all forms TB (incidence rate ratio [IRR][β7] = 1.136 [1.072, 1.204]; p ≤ 0.001) and B+ TB notification rates (IRR [β7] = 1.141 [1.058, 1.229]; p = 0.001).

A significant trend was observed, indicating a higher in-hospital mortality with increasing normalized lactate load (quartile 4 vs. quartile 1: 62.7% vs. 24.2%, P < 0.001) as shown in Table 1 .

Associations with Hannum, PhenoAge, and GrimAge but not Horvath, exhibited a significant trend with increasing deprivation levels ( P test for trend, Hannum: P = . 001, PhenoAge: P < .001, and GrimAge: P < .001) ( Table 2 ).

There was a significant trend of increase in the annual average number of SAP performed per one glaucoma patient (from 0.63 to 0.87, β = 0.024, R 2 = 0.940, p < 0.001).