“a possible trend”

Although the association between age and tumor grade did not reach statistical significance ( p =0.051), the result was marginal and suggested a possible trend that may reach significance in larger studies.

Over the 4 study years, we noted a possible trend of decreasing utilization of ICI monotherapy, which could be attributable to decreased patient numbers in 2020 or secondary to an increase at our academic center in ICI-based clinical trial options that enrolled immunotherapy-naïve patients, who were thus excluded from this observational study.

Although there is a possible trend towards a higher potentiation of nAChR in female mice, this was not found to be of statistical significance (see Author response image 1 below).

These data suggest a possible trend towards improvement in post-MI LV expansion in mice that were given pre-incubated VSEL-SCs as compared with vehicle-treated mice.

Therefore, it may suggest a possible trend toward benefit in POD prevention.

These observations indicate that multi-target drug discovery is indeed a status over the past decade and a possible trend in the future, although many single-target drugs are still used today.

Despite these caveats, the direction and consistency of effect estimates across multiple analytic approaches (HR range: 2.19–2.86) suggest a possible trend toward inferior survival in the (C)RT-based group.

To rule out a possible trend of dissimulation, we examined the correlation between the Neuroticism scores and the Lie scores.

Mild portal fibrosis was found in 50% of patients suggesting a possible trend of acute hepatitis towards chronicity.

The interaction test suggested a possible trend toward effect modification by baseline NIHSS ( p for interaction = .068), which should be interpreted as exploratory.

In addition, the beta diversity analysis of the bacterial microbiota in PLWH-CoV compared with that of PLWH suggests a possible trend toward an increase in prevalence of opportunistic pathogens.

We used the Kruskal-Wallis test to determine a possible trend in the temporal development of AWFR of normoxic cultures.

Explorative comparison of synthesized data did not show the superiority of one administration route over the other, although unadjusted comparison showed a possible trend toward faster recovery after IV administration.

Over the 22 weeks, the ratio decreased from 1.9 to 1.7, pointing toward a possible trend that adjustment of muscle balance precedes strength gains.

However, GS4 and GS5 (family acceptance of illness and communication about the disease) showed p -values close to statistical significance ( p = 0.09 and p = 0.06, respectively), suggesting a possible trend toward improvement in these domains.

Although lower, the CVI was not significantly different in cCSC and fellow eyes compared with controls (38.14 ± 5.55%, 37.23 ± 6.41%, and 40.65 ± 3.53%, respectively; P = 0.066), indicating a possible trend toward a lower CVI.

The data, however, suggest a possible trend of decreasing δ 66/64 Zn with increasing S/N.

Inhibition of ATR suggested a possible trend to increased p21 mRNA expression ( Figure 3 H). 3.4. siRNA Knockdown of DDR Kinases To confirm these pharmacological data, we employed a gene-silencing approach to individually knock down ATM, ATR and DNA-PK. siRNA inhibition caused selective and specific reduction of each target mRNA within 24 h and was maintained for at least 96 h ( Supplementary Figure S3 ).

18 , 22 Subgroup analyses of those with chronic hypertension suggest a possible trend toward small for gestational age, birth weight <10th centile (13.9% versus 19.7%; adjusted odds ratio 0.66, 95%CI 0.44‐1.00); however, it is notable that in this subgroup the primary perinatal outcome was no different (odds ratio 1.08, 95%CI 0.78‐1.51).

Buried surface area (BSA) for the TMC + CIB complexes ( Figure 8—figure supplement 2A, C and E , Figure 8—source data 2 ) revealed a possible trend in which TMC1 and TMC2 have more contacts with CIB3 than with CIB2.

Indeed, the halogen bioisostere‐substituted analogs, such as 3 e (4‐Me) and 3 f (4‐CF 3 ), also exhibited enhanced activities, suggesting a more important role of the hydrophobic over the halogen bond effect in this context. Similarly, evaluation of the 3‐halogen substituted compounds ( 4 a – 4 d ) also indicated a possible trend of classic halogen bonding (3‐F ( 4 a )>3‐Cl ( 4 b )>3‐Br ( 4 c )≈3‐I ( 4 d ), Table 2 ), albeit with slightly weaker potency when compared with that of their 4‐substituted counterparts.

53.8; p = 0.053), the near-significant increase in EFW percentiles, calculated using AC and other fetal biometric measures to estimate the overall fetal growth rate, suggests a possible trend toward accelerated fetal growth in the GDM group.

Disabilities in activities of daily living (mobility, self care, household maintenance) showed a possible trend towards improved functioning, but the effect size was small.

Hence, to confirm a possible trend of increasing education being associated with better perceptions of healthy eating, further studies should be made with more people from lower levels of education.

In PLN, RRV-infected NOD mice showed a possible trend for increased interferon-γ production by CD8 + T cells on day 5 ( Fig. 6f ), and interferon-γ levels increased on day 7 in NOD.IFNAR1 −/− mice.