Barely Significant
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“a positive trend”

11,006 sentences · 11,006 papers · 20,836 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

127 , 128 A phase 1 study of a single intra-articular dose of SM04690 in 61 participants with moderate osteoarthritis showed acceptable safety, with exploratory clinical endpoints that showed a positive trend towards improvement in pain and joint space narrowing. 129 A phase 2 study of 455 individuals with unilateral knee osteoarthritis, although not reaching its primary endpoint (improvement of WOMAC pain at week 13), showed improvement in pain and an increase in joint space indicative of disease modification, which was especially evident in people with unilateral disease. 130 In May 2019, the phase 3 studies were launched (registered on ClinicalTrials.gov , NCT04385303 ).
These recent wins may reflect a positive trend in promoting women scientists in Japan, possibly influenced by movements such as the one led by the Japan Science and Technology Agency. 26 However, further drastic changes and efforts are warranted among scientific communities, the general public, and policymakers to address this severe gender imbalance.
31 For the other six studies, three showed a positive trend favoring the intervention, 30 , 36 , 39 two showed a negative trend, 29 , 34 and one showed no effect. 37 A meta‐analysis of four studies with suitable outcome data, 30 , 31 , 34 , 39 which represented six intervention arms, showed a significant overall effect on BMI z‐score of −0.06 (95% CI [−0.10, −0.01] kg, p = 0.01; four studies, 423 participants [270 intervention group and 153 control group]; I 2 = 0%) favoring the intervention group (Figure 2 ).