Barely Significant
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“a positive trend”

11,006 sentences · 11,006 papers · 20,836 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

2 This burden is further intensified by longer life expectancy—a positive trend that, while welcome, also contributes to population ageing and the rising prevalence of chronic disease. 3 Interdisciplinary treatment (IDT), a complex intervention defined by multiple interacting components, integrates physical activity, education, cognitive–behavioral therapy, and pharmacological strategies. 2 It remains the most comprehensive approach for managing chronic pain. 2 However, its long-term effectiveness remains uncertain.
156 , 157 A RCT with safinamide did not found significant differences between treated and untreated groups, but post-hoc analyses revealed a positive trend, warranting further investigation in larger studies. 158 Other studies with SNRIs (duloxetine) and SSRIs (paroxetine and escitalopram) have not demonstrated significant effects on apathy, despite the known emotional component present in some patients. 159 Non-pharmacological interventions Non-pharmacological therapies for apathy in PD offer promising but very limited evidence.