“a numerical trend”

When overall survival data are evaluated, a numerical trend toward shorter survival times in the HER3-positive group was observed, consistent with the literature, though statistical significance was not reached.

Discussion In this randomised controlled trial, adjunctive silodosin after ESWL did not achieve a statistically significant improvement in the primary endpoint of overall SFR compared with standard care, although a numerical trend towards higher clearance was observed.

In the IDEAL-LM study that included 818 patients undergoing LM PCI, a biodegradable-polymer everolimus-eluting stent followed by 4-month DAPT demonstrated noninferiority compared with a durable-polymer everolimus-eluting stent followed by 12 months of DAPT, although a numerical trend toward higher ischemic event rates was observed in the biodegradable polymer stent with the 4-month DAPT group [ 73 ].

Likewise, the R a scores show a numerical trend of the multi-package sample similar to that of the LER score, reaching maximum values of 94–96 in the white CCT range between 10000 and 2000 K.

Nonetheless, the T-VEC-pembrolizumab group showed a numerical trend toward longer median PFS (14.3 months vs. 8.5 months) and slightly higher ORR (48.6% vs. 41.3%) and DRR(42.2% vs. 34.1%), while maintaining a comparable safety profile [ 74 ].Although the combination of T-VEC and pembrolizumab did not achieve a significant overall survival advantage in the first-line setting for advanced melanoma, it remains under active investigation in PD-1 inhibitor-refractory melanoma and other malignancies.

Moreover, there was a numerical trend towards more error-prone responses after go trials than cue-only trials (8.6% vs. 7.2%).

It is also notable that in the first experiment there is a numerical trend toward an influence of orientation on fixation duration.

Among the HBeAg-positive patients there was a numerical trend of reduced LTCs between the NA treatment (3.4%, 20/587) and no treatment (12.0%,56/468) (RR:0.24, 95%CI: 0.14-0.40; Figure 7 ).

On that day, differences between groups did not reach statistical significance ( p > 0.05), although a numerical trend was observed in IL-6, CRP, the PaO 2 /FiO 2 ratio, WBC count, and temperature.

An early study with recombinant growth hormone was negative; however, there was a numerical trend towards motor improvement in the growth hormone treated group.

In this respect, it is interesting to note that, in the present study, there is a numerical trend for pseudowords preceded by pseudowords to be slower than pseudowords preceded by words.

While a numerical trend suggested better survival with daily amphotericin compared to alternate-day dosing, the difference was not statistically significant in this cohort; conversely, statistically significant associations between treatment schedule and disability were observed, possibly reflecting complex interactions among dosing, cumulative exposure, supportive care and selection bias (sicker patients may have received alternate dosing) ( 5 , 8 , 9 ).

Nevertheless, Experiment 2 revealed a numerical trend towards such an effect, thereby warranting a more elaborate discussion.

Conclusion Higher EGFR VAF was significantly associated with improved overall survival in patients with EGFR-mutated NSCLC treated with first-line osimertinib and showed a numerical trend toward longer progression-free survival.

This was also observed among patients with T2D [ n = 304] (− 31.9 mg/dL at 1 year, P < 0.0001); there was a numerical trend towards reduced FPG in patients with T1D [ n = 14], but this was not significant (− 36.7 mg/dL at 1 year, P > 0.05 [Supplementary Material Fig.

There was a numerical trend towards increases in rates of nausea, vomiting and headache with increasing BMI classification, regardless of patient treatment group.

A numerical trend was observed towards upregulation of Fra-1 gene in the HS sham group followed by an inclination towards downregulation in both the SP5 and SFO regions within the LLTS treated group.

Following two weeks intervention, the change from baseline of the global score in the 8 g/day dose polydextrose group compared to the placebo showed a numerical trend towards improvement, which after 4-weeks intervention was significantly different ( Table 3 ).

A numerical trend toward longer PFS was observed among patients receiving SBRT during immunotherapy, although the differences were not statistically significant.

Over 26 weeks, switching to IDegAsp from glargine U100 or U300 was associated with significant reductions in the daily total and basal insulin dose; furthermore, numerically fewer patients required prandial insulin injections at EOS compared with baseline, with a numerical trend toward a lower daily prandial insulin dose after initiating IDegAsp.

In stratified analyses, patients with wider baseline QRS duration and female sex showed a numerical trend toward greater benefit with the AP strategy, although these findings did not reach statistical significance and should be interpreted cautiously.

The Relationship Between the Severity of Cervical Inflammation and Cytological Abnormalities and HPV When examining the relationship between the severity of cervical inflammation, cellular abnormalities, and HPV carriage, a numerical trend toward higher rates of abnormal cytology with increasing inflammatory severity was observed; however, this association did not reach statistical significance ( p = 0.159).

Although there was a numerical trend in the predicted direction, which did not differ substantially between learning conditions (Fig. 4b ; Supplementary Fig. 5 ), we found no direct effect of signed image RPEs on memory ( ps ≥ 0.19; α corrected = 0.0125; Supplementary Table 12 ).

Most comparative studies evaluating two‐row versus three‐row circular staplers have reported either lower anastomotic leakage rates or a numerical trend favouring three‐row devices [ 4 , 5 , 8 , 10 ], although these findings have varied according to study design and methods of confounding adjustment.

PFS by BICR showed a numerical trend favoring nivolumab plus SOC across multiple subgroups (HR<1) ( figure 3 ).