“a nonsignificant trend”

A nonsignificant trend was observed wherein ICI‐related hypothyroidism was more common in the 65–75 years group, while ICI‐related arthritis was more frequent in the > 75 years group. 4 Discussion ICI‐associated AEs significantly complicate cancer immunotherapy, particularly in geriatric patients who face increased risks due to age‐related immune senescence [ 12 , 13 , 14 , 15 ].

A nonsignificant trend favoring CHG-A was observed in clean-contaminated procedures and for deep SSIs, suggesting a context-dependent effect that warrants targeted investigation.

Surprisingly, in chronic DC 12 -adapted animals, succinate levels were either significantly reduced or exhibited a nonsignificant trend in that direction ( Figure 6H ), arguing against the theory that succinate paracrine signaling contributes to the metabolic phenotype of DC 12 -fed animals.

Categorizing time after symptom onset into <3 days, 4–7 days, 8–14 days, and 15+ days showed odds of death relative to those presenting 8–14 days after symptom onset (group with the lowest odds of death) to be greatest in those presenting <3 days (OR, 3.1; 95% CI, 2.25–4.32) but still increased in those presenting 4–7 days (OR, 1.5; 95% CI, 1.12–2.04), and with a nonsignificant trend to be worse if presenting >14 days (OR, 1.3; 95% CI, 0.85–2.00) ( Figure 3 ).

Of note, a nonsignificant trend for exposure–safety relationship was reported for copanlisib in the phase II CHRONOS‐1 monotherapy trial at the primary data cutoff. 32 The current analysis provides further elucidation of exposure–safety relationships in the larger phase III CHRONOS‐3 trial, supporting no significant relationships.

Also, although ABI <1.0 alone was still found associated with the risk of AF, ABI >1.40 showed a nonsignificant trend in association. 6 Similar results were also reported by Griffin and colleagues, who performed an analogous analysis in the CHS (Cardiovascular Health Study) cohort, an observational population‐based study about risk factors for cardiovascular disease and their influence in disease progression in elderly (≥65 years) subjects. 7 To obtain more robust evidence about the relationship between PAD and AF, we merged together data coming from these 3 large population‐based studies: ARIC Study, MESA, and CHS.

A marginal main effect of target status ( b = 0.00673, SE = 0.00350, 95 CI% = [−0.000138, 0.0136], t (56) = 1.920, p = 0.060) suggested a nonsignificant trend for faster responses when forming impressions of low-status (vs high-status) targets.

The human cDNAs were roughly equivalent to one another, although there was a nonsignificant trend of increased activity for ph F8 -ΔF. pz f8 injected into wild-type larvae similarly exhibited thrombus formation consistent with the f8 +/+ ; at3 –/– mutant phenotype ( Figure 5 D).

Association between physical activity and cognitive function While the decline in composite cognitive performance from baseline to follow-up did not reach statistical significance ( P = 0.635), we observed a nonsignificant trend toward group-level cognitive decline.

20 observed significant time effects on EF, OF, IS, and OS, with a nonsignificant trend in overall improvement.

To the contrary, in the pre-SMA, there was a nonsignificant trend for phonemic relative to semantic fluency to be stronger in L1 than L2 although this differential effect of language did not reach statistical significance ( Z < 1.6; P > 0.05 uncorrected), see Table 4 for details.

TMφ from COPD subjects displayed a nonsignificant trend toward increased IL-36G expression in cells from smokers and COPD subjects compared with controls ( Figure 2A ).

However, a subgroup analysis of patients with SSc-PAH included in this study revealed a nonsignificant trend towards improvement in 6MW distance (3 m improvement in SSc-PAH vs. 46 m in IPAH) [ 89 ].

The hazard ratios for KM use showed consistent results for falls up to 10 medications, with a nonsignificant trend for 10 or more medications.

25 Our data show a nonsignificant trend indicating some tamoxifen benefit also for patients with ER‐positive and PR‐negative disease.

There was a nonsignificant trend toward higher systolic and diastolic blood pressure in the group without diabetes despite the fact that all patients were treated with antihypertensive therapy.

Furthermore, compared with upper extremity fractures, our study demonstrated significantly increased odds of DVT with lower extremity fractures as well as a nonsignificant trend toward increased odds with pelvic fractures.

However, after adjustments, women with high PmpI antibody reactivity showed a nonsignificant trend towards decreased live births (AOR 0.6, 95% CI 0.1–4.0). 4.

IIH patients with anemia demonstrated a nonsignificant trend toward higher frequencies of blurred vision (44.8% vs 34.4%), diplopia (20.7% vs 9.4%), and transit visual obscurations (17.2% vs 9.4%) compared with non-anemic patients ( P > .05).

This adjustment revealed a nonsignificant trend toward a better CV survival profile in patients who took RAS blockers (ACEI or ARB) compared with patients who started therapy with a ß-blocker at the end of follow-up ( Figure 3 ).

The prevalence of PIFS in the current study was comparable with observations from studies of sequelae after other infections, 8 , 9 , 10 , 44 , 45 and also yielded a nonsignificant trend toward a higher prevalence in the SARS-CoV-2–positive group.

However, bone resorption as indicated histomorphometrically by the erodic surface did not differ between the three groups, although a nonsignificant trend toward a higher number of osteoclasts was found in the uremic ATx rats.

Green-light exposure showed a nonsignificant trend toward a decrease in the SCL [ Fig. 1(f) ]. 3.1.4 Neurosystemic functional connectivity Stimulus-evoked changes in cerebral parameters and systemic physiology correlated statistically significantly for seven pairs of variables: [ O 2 Hb ] (RVC) versus MWA (RPFC), r s = 0.505 ± 0.474 ; [HHb] (LPFC) versus LF, r s = 0.424 ± 0.383 ; [tHb] (LPFC) versus MWA (RPFC), r s = − 0.399 ± 0.419 ; Q versus MWA (RPFC), r s = − 0.379 ± 0.440 ; [HHb] (RVC) versus MWA (RPFC), r s = − 0.358 ± 0.393 ; [HHb] (LVC) versus HF, r s = 0.337 ± 0.374 ; and [HHb] (LVC) versus Q, r s = − 0.311 ± 0.320 .

Although methicillin resistance was not independently associated with recurrent bacteremia in adjusted analyses, we did observe a nonsignificant trend toward increased recurrence with MRSA, both in the primary analysis and the propensity score-matched model.

We did, however, identify a nonsignificant trend in pregnant females, where genital MusGHV-1 positive individuals had lighter body weights than those that tested negative ( Figure 1 ), indicating that during pregnancy, reactivation may lead to decreased body condition [ 61 ], or—conversely—that reduced body condition during pregnancy may promote MusGHV-1 reactivation [ 62 ]. 3.1.