Barely Significant
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“a nonsignificant trend”

5,407 sentences · 5,407 papers · 7,516 search hits before verification · confirmed specimen

Sighted at

p<0.1

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

suggested that differing neuromodulator expression could account for size difference, but found that the expression of adrenocorticotropic hormone (ACTH), serotonin, β-endorphin, and met-enkephalin was similar in GBCC and conventional BCC.[ 13 ] Other authors suggest that a weakened immune system plays an important role in tumorigenesis,[ 1 ] and at least one study has found single-nucleotide polymorphisms in genes important in immune regulation in patients developing BCC (of any type, not specifically GBCC).[ 22 ] Our study showed a nonsignificant trend toward more host inflammation in GBCC compared to conventional BCC; this finding would suggest that patients with GBCC can mount a host response, although our study was not designed to assess the functional capacity of the infiltrate.
One study reported no significant association between high PD-L1 levels and overall survival, 15 while another study reported a nonsignificant trend that higher levels were associated with shorter overall survival. 18 The results in Table 1 and those reported by Gu et al 9 suggest that elevated PD-L1 levels are associated with several HCC characteristics that are also risk factors for early tumor recurrence.
By Insulin Use The incidence of the key secondary CV outcome also was lower in patients treated with finerenone compared with those who received placebo, with a nonsignificant trend showing greater risk reduction with baseline insulin use (HR 0.82 [95% CI 0.69–0.97] with insulin use at baseline vs.