Barely Significant
← all phrases

“a negative trend”

4,202 sentences · 4,202 papers · 9,832 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Finally, our study, by focusing on health outcomes exclusively, did not look at the impact of the crisis on health systems, such as shortages in health workforce and medical supplies, where several studies have shown a negative trend during the financial crisis. 65 66 A review of this literature was beyond the scope of this study and it is left for future research.
To our knowledge, apart from one study which reported a positive association, 24 most studies, including several meta-analyses, concluded on either no association or a negative trend with COVID-19 risk or severity. 6 – 13 , 25 – 29 These studies can have a risk of confounding bias or collider bias. 30 , 31 To limit confounding, we restricted the study population to a more homogeneous population of treated hypertensive patients with no known cardiovascular comorbidity and no major comorbidity suspected to increase the risk of COVID-19. 32 We selected patients younger than 80 years treated over a long period of time with drugs with similar indications in 3 mutually exclusive classes of antihypertensive drugs to limit indication bias and confounding.