The meta-analysis found no significant differences between the adherent and non-adherent groups, which were defined based on their phenylalanine levels, but showed higher vitamin B12 levels (fixed-effects model, SMD: 1.080, 95% CI: 0.754, 1.405, p < 0.0001) and a near-significant trend toward higher folate levels (random-effects model, SMD: 0.729, 95% CI: −0.032, 1.490, p = 0.061) in regular formula consumers.
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For IgG, cough remained significantly associated with higher IgG levels (Estimate = 546.32, p = 0.036), while sore throat showed a near-significant trend ( p = 0.061).
No significant associations were found with other serological markers, except for a near-significant trend with anti-Ro (anti-Ro/SSA antibodies) (P = 0.062).
Pain intensity decreased significantly in Group C compared to Group A (mean difference = 10.72, p < 0.001) and showed a near-significant trend versus Group B (mean difference = 6.50, p = 0.062).
When analyzing the latencies of individual behavioral elements, rank score and dogs’ age had a near-significant trend-like effect on the latency of rearing (rank score: exp(β) = 3.480, SE = 0.669, z = 1.86, 95%CI = (−0.0637–2.5579), p = 0.0622; age: exp(β) = 0.863, SE = 0.079, z = −1.86, 95%CI = (−0.3016–0.0081), p = 0.0632).
A near-significant trend was observed between younger age (<40 years) and a higher stricture incidence (p = 0.063).
borderline significancep = 0.063
PIV showed borderline significance in the highest tertile [OR = 2.070 (95% CI: 0.961–4.460) in Model 3, p = 0.063], with a near-significant trend (P for trend = 0.069).
A near-significant trend was also found for DBP ( p = 0.063).
Notably, when patients were divided according to histological types, there was a trend of higher levels of BACE1-AS in the mixed hepatocellular carcinoma (HCC)/hepatocellular cholangiocarcinoma (CAA) compared with HCC alone; the P-value indicated a near-significant trend overall (P=0.063).
A near-significant trend was observed for women with seven or more pregnancies (OR = 3.35, P = 0.064), indicating a potential positive association between higher parity and perception.
Platelet count at diagnosis showed a near-significant trend toward association with chronicity (adjusted OR 1.057 per 1 ×10 3 /μL increase; 95% CI 0.997-1.120; p = 0.065), while age at diagnosis was not independently associated (adjusted OR 1.095; 95% CI 0.891-1.347; p = 0.388).
AA) also showed no statistically significant association in the overall analysis (OR = 1.157, 95% CI = 0.903–1.484, P = 0.249), though the HWE-Y subgroup analysis suggested a near-significant trend (OR = 1.342, 95% CI = 0.982–1.835, P = 0.065) (Fig. 4 , Table 2 ).
In contrast, treatment frequency demonstrated a near-significant trend in the buffy coat group (χ 2 =17.42, P=0.066), suggesting a potential cumulative or dose–response relationship, whereas no such association was observed in the apheresis group (χ 2 =0.33, P>0.05).
Endocrine profiles measured on days 1–3 of the menstrual cycle (including AMH, FSH, LH, Estradiol, progesterone, TSH, prolactin, and fasting blood sugar) did not reveal any significant intergroup differences, although there was a near-significant trend in LH levels ( p = 0.066).
A near-significant trend towards lower than the control uptake could be seen at day 14 of letrozole therapy for ER+ tumors ( p = 0.067).
There was also a near-significant trend for fewer total migrated Ilk − / − OPCs at the 4 h time point (p = 0.0675; Fig. 5 c), an indication of reduced capacity to initiate migration.
Furthermore, pairwise comparisons revealed a near-significant trend toward a higher number of parasite species at house entrances compared to latrines (mean 1.16 vs. 0.778, p = 0.0682; Fig. 3 ).
No significant differences were observed in urban–rural distribution, lipid-lowering therapy, or uric acid–lowering therapy, although the latter showed a near-significant trend ( p = 0.069). 3.1.
Consistently, both antibodies elevated ADPR production in MM cells, with DARA reaching statistical significance (p = 0.03) and ISA showing a near-significant trend (p = 0.07).
Interestingly, BeWo cells in which U2AF65 was overexpressed had a near-significant trend in JMJD6 reduction compared with control (0.55 ± 0.10 vs. 0.23 ± 0.002 JMJD6/GAPDH expression; P = 0.07) ( Figure 2 D).
Although overall treatment time exceeding 56 days showed a near-significant trend toward worse outcomes (p = 0.07 for CR/PR vs .
The cognitive group showed significant gains in both language ( P =.03) and orientation ( P =.03), as well as a near-significant trend in visuospatial ( P =.07).
The difference in PFS benefits across treatment line subgroups was observed as a near-significant trend (P = 0.070) ( Figure 2B ). 3.3.
The risk of CV diseases showed only a near-significant trend when therapy duration of at least 30 days (or all three strata) was assessed collectively for risk analysis (OR=1.02%, 95% CI=1.00–1.04, P =0.07).
Although overall knowledge of strabismus and ocular surface diseases remained low across the sample, a near-significant trend was observed for strabismus knowledge and years of teaching (p = 0.07), suggesting that increased classroom exposure may improve familiarity with such conditions.