“a favorable trend”

Although no head-to-head trials have directly compared these regimens, atezolizumab plus bevacizumab has demonstrated a favorable trend in the overall response rate (30.0% vs. 20.1%), median overall survival (19.2 vs. 16.4 months), and progression-free survival (6.9 vs. 3.8 months).

The results indicated a favorable trend for prophylaxis, with a significantly lower joint ABR found in the intervention group [RR = 0.09; 95% CI: (0.06, 0.14)] as compared to the control group.

Neflamapimod (target class: inflammation), a p38α kinase inhibitor, demonstrated a favorable trend for NRGN and decreased CSF levels of pTau181 and tTau in comparison to a placebo.

Regarding the predisposition towards engaging in other leisure activities (LAs) offered in the analyzed municipality, there is also a favorable trend towards them (81.29%).

This encouraging decline suggests a favorable trend in physical activity levels among older Malaysians over recent years.

Moreover, a favorable trend for EFS was revealed, although statistical significance was not already reached [ 99 ].

While our study did not find statistically significant associations between TILs and these parameters, we observed a favorable trend toward higher TILs in cases with smaller tumors and no nodal metastasis.

Patient self-assessment demonstrated a favorable trend toward greater clinical benefit with buffy coat PRP.

Excitingly, this translated into a favorable trend toward better functional outcomes.

45 , 46 Our study results showed that while outcomes of concurrent chemoradiotherapy were comparable to systemic treatment alone (ORR: 78% vs 69%, mPFS: 13.4 vs 9.2 months), the concurrent radiotherapy group demonstrated a favorable trend in hazard ratio (HR = 1.78, 95% CI: 0.70–4.54) suggesting better prognosis, though the difference did not reach statistical significance ( p = 0.23).

Additionally, the pembrolizumab arm also showed a favorable trend in EFS (HR = 0.63 [95% CI 0.43-0.93]).

Other efficacy endpoints While there were no significant LI + CIZ + SOC advantages over SOC alone for PFS and LRC in the overall population, a favorable trend was observed for the ITT LR group in the case of the PFS ( Supplementary Figure S6 ), with a hazard ratio of 0.76 (95% CI: 0.55–1.04).

The secondary and exploratory results show, in general, a favorable trend for the active product.

Specifically, in the ADMIRAL trial, the CRc rate among patients with prior FLT3 inhibitor exposure was 52%, with a HR for OS of 0.60 (95% CI, 0.30–1.21), indicating a favorable trend toward improved survival.

This reduction was associated to unchanged EF and to a favorable trend in the measurements of diastolic function.

Due to the presence of confounding factors (stability mainly due to the cortical component) in this early healing phase, a significant advantage in the use of bioactive surfaces is not detectable, even if a favorable trend is apparent.

For instance, a favorable trend in the maternal mortality rate has been reported and attributable to 5 major reasons including a decreased fertility rate [ 16 - 18 ], later marriages and childbirths [ 19 ], improved rural women’s literacy [ 20 - 22 ], better access to emergency health (especially obstetric) services, and broadened maternal and childbirth care via the nation-wide health network.

While pembrolizumab combined with CCRT showed a favorable trend towards improved event-free survival (EFS) compared to placebo with CCRT, the difference was not statistically significant.

A favorable trend towards a complete ST-segment resolution at 180’ was observed in enoxaparin groups.

In the present analysis, metformin also showed a favorable trend, but it was not significant, possibly because of a small sample size.

After 3 months of VNS, the subjects had significant improvements in NYHA class, Minnesota quality of life, QOL, (from 52 ± 14 to 31 ± 18), left ventricular end-systolic volume (from 208 ± 71 to 190 ± 83 ml), and a favorable trend toward reduction in end-diastolic volume [ 62 ].

When all four highly heterogeneous studies were excluded, the OR adjusted to 18.70 (95% CI: 14.77–23.40; p = 0.16), indicating reduced precision but still suggesting a favorable trend toward renal benefit with TAF.

A favorable trend was also associated with a decrease in white bread consumption during SARS-CoV-2-related isolation in men, but it remained the dominant food.

No significant improvements were observed between the With- and Without-ICI groups in OS and ORR meta-analyses, but the With-ICI group had a favorable trend in OS.

Our ECGEA cohort of ESCC patients receiving anti–PD-1 monotherapy demonstrated that high ENTPD1 (CD39) expression was associated with improved clinical outcomes (log rank P = 1.5 × 10 − 11 ), with a Cox HR of 0.35 (95% CI 0.09–1.31), indicating a favorable trend with imprecise effect (Fig. 5i ).