Barely Significant
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Do Super-hydrophilic Surfaces Affect Implant Primary Stability in the Early Healing Phase of Osseointegration? A Systematic Review with Metanalysis.

Oral Health Prev Dent · 2025 · PMC12412763 · PMID 40853239

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Analyzing the data related to marginal bone loss, the results showed a slight advantage in favor of bioactive implants, although this difference did not reach statistical significance.

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a favorable trendno p-value reported
Due to the presence of confounding factors (stability mainly due to the cortical component) in this early healing phase, a significant advantage in the use of bioactive surfaces is not detectable, even if a favorable trend is apparent.

also in 1,335 other papers

a positive trendno p-value reported
The results of the ISQ extrapolated from the literature analyzed in this review showed a positive trend in favor of bioactive implants beginning at one month from insertion, although this was not statistically significant.

also in 11,005 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.