Compared with lapatinib plus capecitabine, pyrotinib plus capecitabine exhibited an over 20% increase in objective response rate (ORR), a significant benefit in progression-free survival (median, 12.5 versus 6.8 months; hazard ratio [HR], 0.39), and a clear trend towards improvement in overall survival (median, not reached versus 26.9 months; HR, 0.69) in patients with pretreated metastatic HER2-positive breast cancer [ 12 – 14 ].
Greater adsorption capacities was observed with a clear trend at higher initial concentrations in respect to the initial concentration of Congo Red.
There was a clear trend of substitutions with lower scores (less frequently substituted to serine during evolution) causing greater toxicity, although different substitutions with the same BLOSUM score produced a range of toxicities ( Supplementary Figure S3B ).
Because few patients presented with arthrosis per month at the center, it was difficult to see a clear trend.
As summarized in the Table 3 , the P j % values correspond to different concentrations of ELOLAd, demonstrating a clear trend in the inhibitor’s performance.
Nonetheless, a clear trend emerged in which overbooking and higher daily caseloads were observed alongside lower therapist satisfaction.
From A through D in Figure 7 , a clear trend was observed: the charring layer becomes larger and more extended, which explains the differences in flame-retardant properties for the four composites.
A clear trend is evident in the three-dimensional figure, showing that glycoform pairs ranked higher generally displayed better AUC values than those ranked lower.
However, there was a clear trend showing that the phenotypes associated with greater cognitive impairment had more widespread seizure involvement, whereas those with seizures restricted to the lateral frontal region appeared to have a lower risk of cognitive impairment as this was most commonly found in the Intact Phenotype .
Regardless, the trial revealed a clear trend toward an OS improvement with nivolumab versus sorafenib, and thus exploration of nivolumab in HCC will continue.
For both temperatures, there is a clear trend that longer non-frozen storage times lead to more deviations.
This indicates that an increase in Cu content could effectively inhibit the accelerated corrosion by bacteria, with a clear trend that higher Cu content yielded more significant inhibition effects. 3.2.
Thus, a clear trend in increasing catalytic activities with increased size of the macrocycles is evident not only per macrocycle but also per Ru unit with TOFs per Ru of 6 s −1 , 8.7 s −1 and 10.5 s −1 for the di‐, tri‐ and tetranuclear macrocycles, respectively.
The results did not show a clear trend and further research is necessary to determine the optimal addition of Cu.
Although diabetes mellitus was not found to be significantly associated with lower FFR, a clear trend was observed, likely reflecting the diffuse, severe atherosclerotic burden characteristic of diabetic patients.
The gravimetric analysis reveals a clear trend of increased sample mass following the electrospinning process.
On the other hand, when lubricating the sample surfaces there was a clear trend to a reduction of the Sa and Sq parameters with increasing nominal pressure in the whole range of pressures investigated.
In our study QRS did not change significantly, although there was a clear trend toward its mild increase with time after MI induction.
50 Herein, we report a metal ion-specific impact on product quality with a clear trend of structure-function relationship to both the mAbs (trastuzumab and antiNaPi2b) and their corresponding ADCs (T-DM1 and anti-NaPi2b-vc-MMAE).
The Seebeck coefficient of the samples tends to decrease with increasing temperature below 900 K, except for the Cu 0.979 Ag 0.02 Zn 0.001 AlO 2 sample, which shows a clear trend of increasing the Seebeck coefficient above 900 K.
On the frontal and transverse planes, knee and ankle angles were primarily unchanged during the test, and a clear trend could not be identified.
Concerning the possible particle size effects on the potential toxicity of BioMPs for aquatic organisms, the literature data do not show a clear trend and are too low to have a critical discussion.
Most biomarkers showed a clear trend of elevation in the severe subgroup, particularly NT-proBNP, troponin, CXCL9, procalcitonin, and D-dimer.
There was a clear trend as the MKI67 levels increased along the PC1 (Fig. 5d ).
This reveals a clear trend for those metrics, but leaves space for new ones, like robustness.