“a clear trend”

In the above examples of promiscuous variants, there is a clear trend of the introduction of the same or similar point mutations which expand BM3′s catalytic repertoire, including: the neutralization of the polar binding mouth of the active site granting access to non-polar substrates (R47L/Y51F), the addition of polar residues to counteract an overly non-polar environment (L188Q), the removal of Phe87 steric hindrance (F87A/V/L/G) and active site reorganizations (A82L/F, A74E, V78L/F).

Their glycosylation modification had a clear trend, as follows: Peak4, Peak9, and Peak10 are all 6-C-glycosylation, while Peak2 (Isochaftoside) is a disaccharylated glycoside, where the sixth and eighth carbon of apigenin are modified by arabinose and glucose, respectively ( Table S2 ).

The results obtained from the Ref-128 control sequence showed a less clear pattern, with larger confidence intervals, although still showing a clear trend toward less divergent ITS sequences for the Cher-6 population ( Figure 9 ).

The correlations with light-absorption and fluorescence properties of the EOM show a clear trend from less to more carboxylic groups substituted BPCAs (e.g., B3CAs/EOM, B4CAs/EOM, B5CA/EOM and B6CA/EOM in Figure S7 ), B6CA and B5CA have higher correlation coefficient than B4CA and B3CA.

Querying the Cancer Dependency Map 86 , 87 for dependencies of 757 cancer cell lines on KMT2A and Menin revealed a clear trend of many cancer cell types to be dependent on KMT2A and/or Menin (Figure 5A ).

Our findings indicated that: (1) PPE can improve the mechanical characteristics of the concrete when used in limited quantities of less than 2%, (2) the UCS and STS tests both revealed a clear trend indicating that a 2% volume of PPE in the concrete is the ideal amount to use, (3) PPE utilization improved the concrete quality compared to the reference mix, as the fibers became more closely dispersed, resulting in an improvement in PV, UCS, FS and STS, (4) regardless of the volume content of PP

A clear trend can be observed with lower activity value in the higher floors.

Although the difference did not reach statistical significance ( p = 0.071), a clear trend was observed in which salivary calprotectin levels increased with the severity of joint damage.

While the initial procedural times were longer than those for manual techniques, the analysis demonstrated a clear trend toward improved efficiency as surgical teams progressed along the learning curve.

The elongation at break (ε u ) did not seem to follow a clear trend with the change in porosity nor dimensions, showing a nearly constant value of about 200%. 3.4.

A clear trend is observed: ultrasound-assisted extraction at higher times (UA-15 and UA-20) consistently leads to higher levels of the most influential ARs (e.g., C 19 , C 21 , and C 25 ), as indicated by the red-to-orange color gradient.

Notably, the results reveal a clear trend of increasing household income with age with participants in the 40–49 age group showing the highest level of household income.

[ 18 ] did not observe a clear trend in total heat production as dietary CP content decreased, similar to this study.

Furthermore, there was a clear trend of decreased stride length and cadence in the ≥ 60-year-old group, which may be due to age-related muscle weakness and decreased joint mobility.

Plotting the changes in the Gibbs free energy of the different supramolecular polymers against the volume fraction of chloroform reveals a clear trend in stability, as previously alluded to ( Figure 3 d; Table S1 ).

51 , 52 Our research identified a clear trend toward coagulation contact phase factors (FXI and FXII) as novel therapeutic targets.

These findings reveal a clear trend: trimetallic nanofluids (Au–Pt–Pd) form more robust, sustained, and structurally stabilizing interactions with the malaria target protein than traditional antimalarial drugs.

The results highlight a clear trend of a loss in helicity as a function of rIAPP concentration.

Accordingly, a clear trend of decreased NDrG and increased HLAd and LYMd was observed from T1 to T3 ( Figure 3 ).

There is a clear trend that neonates with NEC have a higher risk for developing complications than those without NEC.

revealed a clear trend in favor of lenvatinib over sorafenib (HR 0.82; 95% CI 0.60–1.15) in terms of OS in HBV-positive patients [ 21 ].

Unfortunately, this oscillating movement is not stable and, year after year, it shows a clear trend for the crack to open over time.

For both cohorts, there was a broad range of OBT susceptibility scores at baseline and a clear trend toward reduced incidence of PDVF among participants with higher overall susceptibility score to newly used antiretrovirals (OSS-new) ( Table 1 ).

The authors did not find a clear trend in prediction success for negative or positive food effects as well as no clear relationship to the BCS class of tested drug substances.

Putative assignments generated by searching the lipid maps database using mass accuracy as the main measure of confidence are also provided and show a clear trend.