“a clear trend”

Of these novel drugs, 47, or 85.5%, were targeted therapies, reflecting a clear trend towards more personalized and effective treatment options.

Even though MIC values vary with the medium strength, a clear trend cannot be observed.

Although there were some minor discrepancies within countries between adjacent MAPLe categories, there was a clear trend of increased rates of caregiver distress with higher levels of MAPLe.

This lack of a clear trend may be due to the relatively young age and preserved cardiac function of the cohort, where subclinical changes in structure may not yet linearly correlate with early renal markers, or due to limited statistical power to detect subtle associations within tertiles.

A 2015 report on child poverty in Japan by the Nippon Foundation [ 7 ] stated that “children raised in households in relative poverty, particularly single parent households, were at an extreme disadvantage in terms of medical care, meals, schooling, and prospects for higher education, and there is a clear trend of these children being unable to escape from poverty in the future”.

The main findings are (1) The mean age of patients receiving TAVI is still over 80 years; (2) There is a clear trend to treat lower risk patients with TAVI with accordingly less comorbidities; (3) procedural complications and 30-day mortality decreased significantly.

The latent spatial structure has a clear trend of positive spatial effects in areas where the epidemic was concentrated (areas 1.0, 2.2, the mainland part of 3.1, 3.2, 3.3 and 5.1) and negative spatial effects in less affected areas ( Fig 6 ).

Following treatment intervention, immune pathways showed a clear trend toward normalization, reflecting the restoration of salivary balance.

40 , 43 , 47 , 48 Furthermore, a recent systematic review and meta-analysis comparing advanced laparoscopy to basic laparoscopy and open surgical placement did not find any difference between the surgical techniques in infectious complications (peritonitis and exit-site infections), whereas we found a clear trend favoring percutaneous insertion for those outcomes. 49 In addition, where differences favoring advanced laparoscopy were found (mechanical complications of leaks), the number of studies included and events experienced were low, and the difference was almost entirely driven by 1 study.

Although quantitative depth profiling of calcium carbonate is not conducted in this study, qualitative examination of cross-sectional samples reveals a clear trend: samples with moderate fiber content (e.g., 0.15%) exhibit relatively homogeneous CaCO3 deposition throughout the vertical profile, whereas samples with higher fiber dosages (≥0.25%) show calcium carbonate concentrated primarily in the upper layers, with visibly reduced mineralization at depth.

In this study, using the revised fishing log data, the calculation of the squid habitat’s annual center of gravity also showed a clear trend of fluctuation, mainly along the eastern area of the Argentine exclusive economic zone (EEZ), which helps to more accurately identify the refined distribution of squid abundance and the central fishery operation area.

The two groups showed no overlap, and the distribution of the samples in the LDA plot exhibited a clear trend of separation, effectively distinguishing sheep meat from goat meat.

A clear trend was not observed in principal coordinate analysis (Figure 1C ).

Supporting the results presented in Table 1 , there is a clear trend of increasing translucency (%) as the manual classification progresses from A to C, suggesting good correspondence between the visual scores and the values obtained through digital image processing.

A clear trend is observed with increasing extrusion passes.

Co‐treatment with Antp‐ QBP1 showed a clear trend toward reduced OC intensity, with values clustering around ∼18 000 a.u./ cell, in contrast to the broader distribution observed in hIAPP‐treated cells (∼15 000–30 000 a.u./ cell), although this difference did not reach statistical significance (Figure 6A ; and Table S2 ).

As a clear trend emerged, demonstrating that the presence of FCS had a detrimental effect on viability, and DMEM had an average of 12% less cell death than DMEM/F12 over the course of the culture period, serum free DMEM was established as the culture medium of choice.

Although the correlation does not provide a clear trend, significant variations in the cell parameters reported for PuO 2 nanoparticles can be pointed out when compared to the bulk PuO 2 reference reported at 5.396 Å. 45 Furthermore, one can note that the reference value is almost exclusively lower than the ones reported for the nanoparticles, strengthening the observation of a potential negative surface stress for nanosized PuO 2 .

We see a clear trend that as the feedforward connection probablity increases, and feedforward connection density increases as a result, the mean dominance duration increases monotonically.

In the case of breast cancer, there is a clear trend of increased incidences in the 20–49 year age group and in the 50–64 year age group consistently for the past ten years with no evidence of decrease.

Wound risk shows a clear trend that necessitates more F2F input in the presence of wound contamination/infection or increased complexity.

In addition, there was also a clear trend, although not significant, towards higher serum ER- β bioactivity in ER-negative breast cancer cases compared with controls ( Table 1 ).

3 Discussion The SAR observed across the four subfamilies reveals a clear trend governing HDAC8 inhibition by squaric acid‐derived analogues.

With regard to habitat complexity, there is a clear trend in brain morphology variation between species, with fish species from structurally complex habitats typically showing larger relative brains, telencephala, and cerebella (see Fig. 2 c).

The LTTR numbers suggest a clear trend towards the reduction of these transcriptional factors in Salmonella reptile commensals such as S . enterica subspecies arizonae, diarizonae, houtenae, indica, salamae and in S . bongori, ( Fig 2 ).