“a clear trend”

Additionally, the intracerebroventricular administration of UFP-101 in LPS-treated rats was associated with increased POMC mRNA expression 4 h after injection and a clear trend towards increased parvocellular CRF mRNA.

The DSMB will also have the power to terminate the study for a variety of reasons, including poor recruitment, AEs caused by the study medications, or a clear trend in live births in one of the blinded treatment arms exceeding our expectations.

A clear trend can be observed considering group structure use in BF in opposition to individual structure use in HP ( Fig 5A ).

sinensis showed a clear trend toward more positive δ 13 C‐CH 4 change rate values when 13 C‐labeled DMSO was applied to plant leaves, except for N. tabacum when incubated in the dark.

Consistent with the training set, patients with high risk scores showed a clear trend of decreased survival rate in 23 of 29 GEO studies (Fig. 4 a-f and Additional file 1 : Figure S1).

Although we observed a clear trend of increasing heterozygosity with higher depth-of-coverage, the slopes for each population were similar and consistently higher in all but one population of M. lugubris ( S5 Fig ).

Despite a smaller cohort of TCP mice in our analysis, a clear trend in sex difference could also be observed.

Although a clear trend of superiority in additional exsanguination to the application of a tourniquet is visible, it might also be that our study is statistically underpowered.

However, an analysis of the GBD data does not reveal a clear trend in this regard.

Although a clear trend between sorptivity and electrical resistivity cannot be identified, possibly due to the different tortuosity and capillary pore distribution along/across the specimens, the inherent different specimen geometry as well as the incorporation of superplasticiser, it is confirmed that in the case of CF/RCF higher values of sorptivity correspond to lower resistivity, while the opposite is observed in the case of GP-doped specimens, in which the matrix densification resulted in the reduction of the ionic conductivity.

ACE2 and CTSL coexpression showed a clear trend of joint upregulation in males (Fig. 3 D).

In contrast, seeds stored at −20 and −80 °C showed a clear trend of viability loss after three years.

Thus, with a few exceptions, there was a clear trend to group the bacterial communities along Axis 1, which explained 51.3% of the variation, mainly by the presence of Vd in the soil mixture, and then along Axis 2, which explained 17.2% of the variation, also according to the inoculation procedure and in a lower extent according to the propagation method, with in vitro -adapted and nursery propagated plants being more similar between them ( Figure 3 ).

Results in relation the penrose hypothesis The longitudinal analysis of prisoner numbers in Germany yielded a clear trend: while the number of people in jail is constantly decreasing, the number of compensation prisoners is constantly increasing.

A clear trend emerged: compounds abundant in young wines, particularly flavan-3-ol monomers (catechin, epicatechin), procyanidin B2, and neochlorogenic acid, steadily decreased over time.

For endogeic earthworms, a clear trend was also observed, with, for instance, a strong decrease in abundance (33%, 50%, and 56% decrease in abundance related to the control at 1, 6, and 12 months, respectively, in the D10 treatment) from the beginning to the end of the experiment.

Although we did not see the formation of the full parallel G-triplex, the simulation shows a clear trend to form cross-hairpin structures between two consecutive G-tracts and parallel G-hairpins.

A clear trend can be observed among reported CRC aptasensors, which predominantly employ a direct assay configuration where the aptamer is immobilized on gold or nanomaterial-modified electrode surfaces.

While the World Health Organization defines elderly as persons over the age of 65 there is a clear trend to an upward shift over the last years, reaching up to octogenarians.

Although this finding did not reach statistical significance, a clear trend was observed.

The results demonstrate a clear trend: as RMSD increases, the accuracy of the model in predicting interfacial residues decreases.

Regarding the occurrence of different medical software categories, a clear trend is visible towards detecting and characterising suspicious lesions, as well as supporting radiotherapy planning, while AI-driven image acquisition approaches are to date underrepresented, giving an obvious priority to AI-driven clinical decision support.

Though we could not observe a clear trend in the beginning, we could observe a stabilization towards the end that is common to both control and glucose cases.

These oncology cases also highlight a clear trend toward integrating multi‐omics data with sophisticated machine learning models to create predictive biomarkers that stratify patients and help identify tailored therapeutic options [ 73 , 74 ].

A clear trend of increasing fluorescence intensity with increasing nucleus volume is observed, consistent with the progressive increase of the size of a cell and its nucleus during the eukaryotic cell cycle, 40–42 and that mVenus-geminin is highly expressed in the later phases of the cycle, once the cell has started its DNA replication.