These overlaps are highly significant (Fisher’s exact test, p<10 −20 ).
Excerpts
It exhibited highly significant associations with multiple musculoskeletal traits, most notably with appendicular lean mass ( p = 1.0 × 10 −20 ), trunk fat-free mass ( p = 1.8 × 10 −8 ), and standing height ( p = 2.0 × 10 −9 ).
Moreover, the overlap between the hyper- and hypo-methylated ESSEs in the Jurkat cells and DLBCL samples was highly significant ( p-value < 1E-20) (top panels, Fig 8B ).
We found a highly significant enrichment, treated as a sample of either ordered or disordered regions (P<1e-20).
For instance, our meta-analysis revealed a clear trend for basophil and NK-cell fractions to increase with age (Fig. 2 a, Stouffer Z = 11, P < 10 −20 for NK and Z = 10, P < 10 −20 for basophils), strengthening preliminary findings from others [ 90 – 93 ].
GO overrepresentation within the 531 gene cluster 7 (macronuclear G1/S, late micronuclear S) showed a highly significant enrichment for processes linked with S phase, including DNA replication ( P = 1.00E-20), DNA repair ( P = 1.03E-18), regulation of the G1/S transition ( P = 0.04), and histone modifiers ( P = 3.36E-3) ( Figure 6B ; Supplemental Datafile 2).
While the prediction of these algorithms was far from being perfect for each individual RNAi trigger, we found a highly significant correlation (Pearson = 90.6%, p < 10 −20 ) between this algorithm’s scores and our average screen score.
This effect is strongest for the pairwise deviation between means (61% reduction), but also highly significant for the other measures ( P < 10 −20 in all cases).
Each of the three possible pairwise regressions were highly significant with p<10 −20 .
We observed highly significant ( p < 1e−20) enrichment for the GO biological process (BP) term “translation”, GO molecular function (MF) term “structural constituent of ribosome”, and GO cellular compartment (CC) term “ribosome” among GO terms for differentially downregulated genes in external cortical tissues after 3 months of storage.
Still, for the remaining animals, the differences in the number of detected SNPs were highly significant ( P < 10 −20 ).
The ciliary modules were found to share on average more than 50% of genes with each other, this overlap statistically highly significant (P<10 −20 for the least significant pair of the datasets; see Table S4 for details on the cross-dataset overlap of the modules).
Fourth, there is a highly significant enrichment for extreme iHS values in genic regions ( p < 10 −20 in all populations; Table S1 ).
Statistical testing further confirmed a highly significant increase in DSC and decrease in AVG HD for both improvements (competition and information aggregation) compared to QuickNAT (Wilcoxon signed-rank test, p < 10 −20 after Bonferroni correction for multiple testing).
Two-by-two χ 2 tests comparing each mutant to ndt80 Δ at the same threshold confirmed that all contrasts were highly significant (χ 2 = 86.7–197.2, df = 1, p < 10 −20 ; full statistics in Table S2 ).
[ 5 ], where they demonstrated a highly significant enrichment for genic regions within the group of loci identified as potential targets of positive selection (p < 1E-20).
There is a substantial (average coefficient -0.6) highly significant (p<10 −20 ) shift of the distribution towards negative values for contrast-dependence (bottom histogram), together with a mild (∼0.16) less significant (p<0.01) shift towards positive values for SNR-dependence (top histogram).
As further confirmation of the quality of the model, analysis of variance of cross-validated residuals (CV-ANOVA) for the PLS-DA model was highly significant (p<1x10 -20 ).
The overlap of Arc-dVenus -enriched genes with activity-regulated and visual stimulus-induced genes is highly significant (each p < 10 −20 , hypergeometric test) ( Fig. 3C,D ).
The highly significant enrichment patterns ( p <1e −20 ) highlight three fundamental mechanisms underlying GR’s superior thermotolerance.
Among them, the pink, purple, yellow, and turquoise modules were highly correlated with the 2-cell to morula stages ( Supplementary Figures S3A,B ), and the correlation was highly significant based on the p value ( p < 10 –20 ).
The GCGC haplotype combination of the 2677G>T, 3435C>T, 1249G>A and −24C>T respectively was found to be extremely significant (p = 1.10e−20) with good drug response to CBZ mono-therapy.
A highly significant association peak (–log 10 ( P ) = 19.89) was identified on chromosome 1, exceeding the significance threshold (interval: 36,313,286–36,586,879 bp, spanning approximately 273.6 kb).
The intraclass correlation coefficient (ICC) for the accuracy rate was 0.982, indicating near-perfect agreement between raters, with a highly significant F test ( P = 1.36 × 10 −20 ).
The association between PRS and phenotypes of the same trait were highly significant (PRS 25-OH-D p = 1.4e − 20, PRS n3-PUFA p = 9.3e − 6, PRS MDD p = 1.4e − 4).