Barely Significant

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highly significantp = 0 0.00010.0× alphaqualifiedgold
Eight patients (8.6%) had an ESS score more than 9, which is the normal cutoff limit.One month later (ESS2) the mean was10.99 ± 4.569 and ranged from zero to 22, and 60 patients (64.5%) crossed the cutoff limit,i.e., the ESS 1 was worse one month following the stroke.The change was also very highly significant ( p = 0 0.0001).
highly significantp > 0.00010.0× alphaqualifiedgold
The exponential increase in rDio3os expression between E and C groups together and separately by developmental stage is highly significant by Chi-square analysis ( p > 0.0001) although the absolute differences in mRNA expression levels between groups are not significant by two-way ANOVA.
highly significantp < 0.00010.0× alphaqualifiedgold
young mice Semiquantitative analysis of the burden of clustered immunoreactive puncta in the hippocampal formation of all 40 mice (i.e., 22 young and 18 aged mice) revealed a highly significant linear trend toward greater load in aged mice ( p < 0.0001 for each of LC3, p62, ubiquitin, MAP2, and synapsin IIa stainings; χ 2 test for linear trend [Fig. 3a–e ]).
highly significantP = 0.00010.0× alphaqualifiedgold
We used the adonis2 function in the qiime2 plugin (q2-diversity) to perform permutational multivariate analysis of variance (PERMANOVA) with 999 permutations, and the included interaction terms (see Table S3 in the supplemental material) and separation of the groups were highly significant ( P = 0.0001).
highly significantP < 0.00010.0× alphaqualifiedgold
37 Another study found a highly significant ( P < 0.0001) change in the median emergency department LOS, from 155 (IQR = 19–346) to 35 (IQR = 9–209) min. 24 Another study found a reduction in mean emergency department LOS from 423 (s.d. 265) min pre-intervention to 210 (s.d. 179) min post-intervention.
highly significantp < 0.00010.0× alphaqualifiedgold
Comparison of change in mean size of the lesion within group A and group B at 4 weeks Within-group analysis for Group A showed a highly significant reduction in lesion size from baseline (Figure 4 ) to the four-week endpoint (Figure 5 ), with a mean score change of 2.0+/- 0.95 (t = 8.16, df = 11, p < 0.0001).
highly significantp < 0.00010.0× alphaqualifiedgold
A meta-analysis based mainly on the findings of six studies pertaining to treatment with clozapine supported a significant overall beneficial effect on suicidal behavior, with a highly significant ( p < 0.0001), 3.3-fold [CI: 1.7–5.7] lower pooled risk of suicidal behaviors with clozapine compared to alternative treatments [ 41 ].
highly significantP <0.00010.0× alphaqualifiedgold
Highly significant differences ( P <0.0001; Mann–Whitney) were seen between concentrations of these variables in patients with metastatic disease compared with localised disease ( Figure 1 ) with median values (IQR) respectively of 22.2 (4.2–111) vs 5.7 (0.6–11.5) mg l −1 for CRP, 189.2 (114.8–303.4) vs 82.3 (575.5–131.1) μ g l −1 for OPN and 186.4 (89.6–336.2) vs 102.5 (61.6–153.9) μ g l −1 for CA9.
highly significantP -value < 0.00010.0× alphaqualifiedgold
No significant differences in the prognostic value are noted between iPET-2 and i-PET-4 with both showing highly significant differences in EFS between the CMR and nCMR patients ( P -value < 0.0001): patients with iPET-2-CMR and iPET-2-nCMR had 3-y-EFS’s of 93.1% and 45.5%, respectively while the respective values for patients with iPET-4-CMR and iPET-4-nCMR were 89.5 and 39.4%.
highly significantp < 0.00010.0× alphaqualifiedgold
When comparing this time span between both study groups we found a highly significant reduction in diagnosis-to-treatment time in the intervention group compared with the control group ( p < 0.0001; Fig. 3 a) with a mean time span of 14 days for the intervention group and 36 days for the control group and with a range between 7 and 81 days.
highly significantP <0.00010.0× alphaqualifiedgold
This difference was found to be highly significant at 5 minutes ( P <0.0001), 30 minutes ( P <0.0001), and 45 minutes after CO 2 insufflation ( P <0.0001) and at 1 minute after extubation ( P <0.0001) but was found to be statistically comparable at 1 minute after CO 2 insufflation and at 10 minutes after extubation.