Excerpts

Using MSigDB to perform gene set enrichment analysis 26 , 27 , we found a highly significant enrichment for binding sites in the Sp1/Krüppel-like factor family 28 ( p < 10 −144 by Bonferroni-corrected hypergeometric test) and for genes downregulated in Klf1 −/− cells ( p < 10 −57 ).

Although the sublamination of the IPL was clearly less organized than in the WT, in this very thin IPL-like neuropil the typical apical/basal pattern was still obvious ( Figures 2 G and 2I) and highly significant (p = 3.0 × 10 −144 ; Figure 2 J).

Another highly significant feature ( p = 5.1 × 10 −144 ) was the number of upstream AUGs.

The overlap between the EPRS and ESR1 LINCS signatures is highly significant (corrected FET p = 3.6e-143, OR = 8.86) (Figure 6B ).

5 G) included 773 genes, which is highly significant ( p = 8.5 × 10− 142 ) with a strong odds ratio of 10.27, indicating that the overlap is about 10 times more frequent than would occur by chance.

In particular, the fluorescence intensity of SUVs preferred by 15GALA-NP increased approximately 2 orders of magnitude compared to free GALA, showing highly significant skewness ( p = 1.12 –141) by comparing the two distributions in a two-sided Welch’s t -test.

The APOE genetic signal remained highly significant in an age-stratified GWAS, on participants with age 60 years or more (OR 1.7, 95% CI 1.63–1.77; P = 2.7 × 10 −141 ; Extended Data Fig. 6 and Supplementary Table 2 ).

Of these, 140 SNPs indexed differences in HDL- and LDL-cholesterol, triglycerides, C-reactive protein, fibrinogen, factor VII, apolipoproteins AI and B, lipoprotein-associated phospholipase A2, homocysteine or folate, some with large effect sizes and highly significant P -values (e.g. 2.15 standard deviations at P = 9.2 × 10 −140 for F7 rs6046 and FVII levels).

The Steiger analysis demonstrated highly significant directional associations for CEP68 using both blood ( p = 1.92 × 10 −137 ) and LAA ( p = 4.88 × 10 −49 ) eQTLs.

This overlap is highly significant by factor of over-representation (4) and P -value ( P < 3.1 e-136).

Genetic analyses uncovered a missense change, c.1288G>A; p.A430T, in the autophagy-related ATG4D gene on canine chromosome 20 with a highly significant disease association (p = 3.8 x 10 -136 ) in a cohort of more than 2300 Lagotto Romagnolo dogs.

Comparison of F ST values on chromosome 1 between PK10 and Thailand were highly significant (pairwise- t = 26.9, d.f. = 1934, p -value = 1.15 × 10 −135 ), and PK10 F ST values were greater than Thailand F ST values in 1387 of the 1935 genes compared (71.6%).

Figure 7B shows there was a highly significant overlap between the genes affected by cordycepin in the two cell lines ( P < 1.44 × 10 −135 by one‐tailed Fisher's exact test).

Furthermore, the Z-score-based meta-analysis of 1,239 animals in the exploratory cohort revealed a highly significant negative correlation between pH and lactate levels at the individual animal level ( r =–0.62, P =7.54 × 10 –135 ; Figure 1B ).

To formally test this, we compared H3 BioID interactors with the MYC interactome ( 56 ), finding a highly significant overlap ( p = 10 −134 ; Fig. 3 G ).

The yield difference between the two basins was highly significant (t = 46.11, p < 10− 133 , Cohen’s d = -2.77), confirming the stark separation of performance states.

Also, notable in cluster 0 res0.75 was a highly significant enrichment (p=6.8×10 -133 ) of genes associated with the NGF-TrkA growth factor tyrosine kinase signaling pathway [ 31 ].

Similar to the genome-wide comparison, we found a highly significant non-parametric correlation coefficient (Spearman's r = 0.62, P = 1.2e-132) for the expression change of these shared differentially expressed genes ( Fig 5A ).

In fact, the correlation between hearing and deaf regional thickness measurements was highly significant (p = 6.85 × 10 −132 ), demonstrating an R 2 value of 0.98.

Five genes associated with pigmentary traits were identified in the analysis with highly significant SNP associations: SLC45A2 (rs16891982, β=−0.546, SE=0.021, p=2.2×10 −130 ), IRF4 (rs12203592, β=1.915, SE=0.118, p=2.8×10 −57 ), HERC2 (rs1667394, β=−0.608, SE=0.02, p=2.8×10 −176 ), OCA2 (rs11855019, β=−0.548, SE=0.022, p=2.4×10 −121 ) and MC1R (rs1805007, β=3.615, SE=0.326, p=7.7×10 −22 ) (online supplementary figure S3 ).

Especially, VIT_00s0324g00050 showed highly significant differential expression ( P = 3.79E-129). qRT-PCR analysis To confirm the results obtained from RNA-seq, relative expression profiles of 30 genes were analyzed by real-time RT-PCR at the three fruit developmental stages in black and white spine grapes.

For KEGG GSs, there was a large number of highly significant GS associations (minimum nominal p = 3.84x10 −129 ); however, the majority of the top results were driven by the 13 GSs which include the human leukocyte antigen (HLA) genes.

Here, only the Cosine and Jaccard results are highly significant ( P < 1.05*e −128 ) when comparing the merged and the study-wise annotation model.

Changes to plan shape Throughout the entire handaxe sample, the correlation between tip length and PC1 ( Fig 14 ) is highly significant (r = .642, p = 1.2889E-128), supporting an allometric relationship between handaxe shape and size.

In our sample, the correlation between FA and MD values was highly significant (whole-brain average r (FA,MD) =−0.75, P =9.9e–128).