Barely Significant

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extremely significantP < 0.00010.0× alphaqualified
* represents P < 0.05, which means the difference is significant; ** represents P < 0.01, which means the difference is very significant; *** represents P < 0.001, which means the difference is extremely significant; **** represents P < 0.0001, which means the difference is more significant than ***; ns means the difference is not significant.
nominally significantP < 1.00 × 10 − 40.0× alphagold
3 , 12 Among the 32 nominally significant gene-based associations ( P < 1.00 × 10 − 4 ), six (18.75%) were issued from a missense|LC (i.e., low-confidence LoF variants) burden set, 19 (59.38%) were issued from a pLoF burden set, and seven (21.88%) were issued from a synonymous burden set ( Supplementary Figure S1 ).
highly significantp < 0.00010.0× alphaqualifiedgold
We found a highly significant increase in the expression of Serum and glucocorticoid‐regulated kinase 1 ( Sgk1 , already 1 h after injection, two‐way ANOVA with Šidák's post hoc test, p < 0.0001) and Glucocorticoid‐induced leucine zipper protein ( Gilz / Tsc22d3 , 2 h after injection, p = 0.0015), both targets of GR transactivation.