The source of variations genotype and year were significant and the genotype by year interaction was highly significant for both traits (p < 0.0001).
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Results A co-existence of B7-H1 + T lymphocytes and FOXP3 + T regs was evidenced by the highly significant correlation of these molecules ( P < .0001) and their expression by different T lymphocyte subsets was clearly demonstrated.
Analysis of variance (ANOVA) demonstrated excellent model fit for the crude enzyme system, with a determination coefficient (R 2 ) of 0.9878, adjusted R 2 of 0.9721, and a highly significant model F-value of 62.93 ( p < 0.0001), as detailed in Table S2 .
In marmot samples, differences in positivity for GIT parasites ( Eimeria spp., Trichostrongylidae, and Ctenotaenia marmotae ) propagative stages over the whole study period were statistically highly significant ( p < 0.0001).
Comparison of regression lines by analysis of covariance (Prism, GraphPad) revealed that the differences between Cx43 slope and Cx26 or Cx40 slopes were extremely significant (P < 0.0001).
A highly significant correlation (R > 0.83, p < 0.0001) was found between the fractional stability parameters of the different state space reconstruction methods (i.e., Equations 4–6) indicating robustness of the parameters to the choice of state space reconstruction method.
A negative trend was revealed between the ISSs and incidence of 14-day rehospitalization with new tSCI diagnosis ( P < 0.0001).
Performance status by ECOG score was strongly associated with survival: patients with ECOG 0 had an MST of 22.5 months (95% CI, 12.1–32.9), ECOG 1 patients 13.3 months (95% CI, 10.4–16.3), and those with ECOG 2 had a markedly shorter MST of 3.3 months (95% CI, 2.8–3.8), with highly significant differences ( p = 0.0001) ( Figure 2 D).
This analysis revealed highly significant main effects of dose (F 4,160 ≈ 848.5, p < 0.0001), wavelength (F 1,160 ≈ 252.2, p < 0.0001), and cellular age-status (F 1,160 ≈ 1466.8, p < 0.0001), indicating that metabolic activity varied significantly with PBM fluence, irradiation source, and replicative aging.
A negative, highly significant correlation was found between AQP1 abundance and the D/P Crea ( r = −0.76, p < 0.0001). 4.
Event-specific cumulative incidence curves were thus estimated from the decomposition of the EFS curves and a computer program (COMPETE) developed at the Institut Gustave-Roussy was used for the calculations. Results obtained using the competing risk approach were compared to the method of ignoring or censoring other events for the data provided here. Results The EFS curves for the three groups are shown in Figure 1. The difference in EFS between the low risk group and both high risk groups was highly significant (P<0.0001).
Results and Discussion The effect of species on the probability of thigmotropism was highly significant between fusarial isolates belonging to FSSC and FOSC (Odds ratio = 2.81, z = 14.634, p < 0.0001).
Pathway analysis revealed the following highly significant pathways (p < 0.0001): nervous system development, metabolism of proteins, and fragile X syndrome (FXS) ( Table 5 and Supplemental Table 9).
A highly significant correlation ( ρ 0.43, p < 0.0001) between cyclin D1 mRNA and protein expression has also been reported [ 29 ].
The quadratic equation so obtained presented a highly significant effect (p < 0.0001) of the solid lipid, surfactant concentration, and sonication time on the PS values.
The logistic regression analysis revealed that 15 out of 19 agronomic factors, including “district” as an independent variable, exhibited a statistically highly significant association ( p < 0.0001) with both CLS incidence and severity when added at first (Analysis I) and last (Analysis III) into the model (Table 3 ).
Permutational multivariate analysis of variance confirmed that compositional differences among the three associations were highly significant (F = 7.658, p = 0.0001, 9 999 permutations), a result corroborated by the rank-based test of similarity ( R = 0.6135, p = 0.0001).
Pathologic complete response was a highly significant predictor of DFS and OS in all treatment groups (HR = 0.45, P < 0.0001, and HR = 0.33, P < 0.0001, respectively).
Highly significant increases of plasma NfL were observed in all cognitively impaired and atypical parkinsonian groups as compared to PD ( P < 0.0001).
spiralis , respectively), and were highly significant in all cases ( P <0.0001).
Duration of pain relief A highly significant difference in the duration of pain relief was found between the intervention group and the placebo group (p = 0.0001).
The interaction term for eGFR and urine ACR was highly significant ( P <0.0001, multiplicative interaction term), indicating that eGFR significantly modified the association between urine ACR and incident AF (Table 2 ).
Furthermore, the results shown in Supplementary Table S2 revealed that for size, the Individual (ID) effect was highly significant at each DPI as evidenced by Goodall F test ( P < 0.0001).
Quantification of Gag clusters at the ventral PM of DMSO (n = 27) or rCD1 treated (n = 26) cells revealed a pronounced (80%) and highly significant (p<0.0001) reduction of Gag clusters in PM PI(4,5)P 2 depleted cells compared to control cells ( Figure 1F ).
The perindopril trials demonstrated a highly significant event reduction (OR 0.78; 95% CI: 0.72–0.85; p < 0.0001 (Fig. 4) .