Adding calcium was associated with a highly significant reduction in SLS prevalence from about 60% without supplemented calcium to 15% in high and medium calcium-supplemented treatments (P < 0.0001, Fig 2 , Table 1 ).
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This effect was highly significant on statistical analysis ( P < 0.0001).
This time, the log-rank statistic comparing the survival times of the two clusters was highly significant ( p = 0.0001).
Main results A highly significant difference in survival over time was noted between SADM and MADM patients (p<0.0001), which was intensified by the presence of a CCC.
In the already cited study on compliance to SCIT, SLIT, and LNIT in children, data on SLIT concerned 806 patients, 173 of whom (21.4%) were noncompliant, with a highly significant difference (p < 0.0001) for a better compliance in hospital setting (90.5%) compared to private office setting (61.2%); the most common reason of withdrawal was the cost of treatment, reported globally in 36.4% of cases, followed by inconvenience, feeling of inefficacy, and side effects ( Pajno et al 2005 ).
ChatGPT-5 again had the highest score (71.67 ± 6.17), followed by DeepSeek-V3.2 (66.00 ± 5.07), Gemini (61.67 ± 5.88), and Claude Sonnet (59.00 ± 6.87), with a highly significant overall difference ( p < 0.0001).
This reduction of the ADT with time was highly significant for both species (Table 3 ; P < 0.0001).
Further, the overall effect of SES was reduced from highly significant (p < 0.0001) in the base model to non-significant (p = 0.07) in model 4.
A highly significant impairment of cell viability, corresponding to a 74% reduction compared to the untreated cells ( p < 0.0001), was observed in 100 μM H 2 O 2 -treated cells, in agreement with the study of Ghaffari et al.
The use of the thiazolidinedione (pioglitazone) was more in outpatients in comparison to that in inpatients, and this difference was highly significant ( P < 0.0001; χ 2 = 29.25).
The chi-squared test for heterogeneity of studies was highly significant ( P < 0.0001) suggesting that the reported HRs of the individual trials are substantially different.
The logistic regression model was highly significant (p < 0.0001, R square = 0.1).
There was a highly significant direct correlation (Spearman's correlation coefficient r = 0.72; P < 0.0001) between the mean lesion size of the adenoma cases and the percentage of significant different texture features between adenomas and carcinomas.
The sulcal depth of the aaLF and ds Comparison of the aaLF and ds depths showed a highly significant difference (p < 0.0001).
This difference was highly significant using a paired t-test with data points paired by year (P<0.0001, df = 11).
The differences among groups were highly significant at each time point ( p < 0.0001).
The model was highly significant with a high R squared ( p < 0.0001, Nagelkerke R2 = 0.83).
A highly significant correlation was observed between DFA and MAGE (r = 0.68, p < 0.0001): high variability correlated with high DFA (and thus, low complexity) ( Figure 3 ).
This difference was highly significant (χ 2 1 = 73.21, p < .0001).
These correlations were also found highly significant with p values < 0.0001 on 43 and 28 degrees of freedom.
In the full sample (ages 40–75), the first-stage Kleibergen–Paap rk Wald F is ≈9.16 (borderline strength), yet the Anderson–Rubin and Stock–Wright weak-IV-robust tests are highly significant (p≈0.0001), indicating a positive effect of retirement on depressive symptoms under weak-IV-robust inference.
In contrast, in YNP we observed a highly significant negative correlation between thermoregulatory behavior and temperatures (air and soil) (air temperature: r = −0.224, P < 0.0001; soil temperature: r = −0.153, P = 0.0037).
All three ratios showed highly significant power exponent β (β for ratio between systolic and diastolic SR long = −0.07±0.02, p<0.0001; β for ratio between systolic and diastolic SR circ = −0.06±0.01, p<0.0001; β for ratio between systolic and diastolic SR rad = −0.06±0.02, p<0.0001).
The fold changes of qPCR and microarray analysis showed a highly significant Spearman correlation of r = 0.804 (p<0.0001).
This difference was highly significant ( p < 0.0001), clearly demonstrating the superior therapeutic effect of Exclzyme Pet in helping the restoration of joint mobility in osteoarthritic dogs. 3.1.4 Willingness to hold contralateral limb The willingness to hold the contralateral limb during a lameness evaluation is a key clinical indicator, offering insight into the severity of pain, compensatory gait alterations, and the degree of joint inflammation.