RNAs Co-expression and Interaction Network The co-expression network of the most highly significant DEGs ( p ≤ 0.0001) was constructed to identify the potential DEGs interaction by using GeneMANIA tool ( 32 ).
Excerpts
The developmental rates to expanded blastocyst stage decreased significantly from group A to group D, and the Cochran-Armitage test confirmed a significant trend of declining expanded blastocyst rate with increasing dBMov/(t3-t2) value ( P < 0.0001).
In both species there is a highly significant increase of segmental duplications around inversion breakpoints as compared to the genome-wide average ( p < 0.0001 in both genomes).
Including the “both” category in the analysis and considering the variables as ordered (surgeons>both>physicians), the association with all three outcomes is highly significant (extended Cochran-Armitage test): recommending VCUG: P <0.0001, recommending continuous antibiotic prophylaxis: P <0.001, recommending surgery: P =0.003.
The average Spearman correlation between the scores of the four hypoxia profiles was 0.82 and highly significant (range 0.71–0.90, p -values < 0.0001, Figure 2 A), demonstrating that the four gene expression profiles rank patients similarly.
RNL lower than 0.650), compared to the controls (statistical differences highly significant, p < 0.0001 for Pt-3, Pt-5 and Pt-8 and p < 0.001 for Pt-4) ( Figure 6 ).
scSFE presented potent hyaluronidase inhibition activity, reaching almost 100% of the level obtained for p -dimethylaminobenzaldehyde (positive control), and the effect was highly significant (**** p < 0.0001).
A gene set/list was considered as having highly significant overlap and included in further analyses if p<0.0001, p values for the MSigdB analysis were calculated using the hypergeometric test.
In case of HaCaT cells, highly significant viability differences were observed between control, ZnPc or TMPyP versus combination-treated cells ( P <0.0001) at both post-treatment times.
All relations were highly significant (all P < 0.0001).
Similarly, the percentage of positive fields for IL-13Rα2 expression in 2+ and 3+ positive specimens in IHC analysis demonstrated a highly significant trend in these specimens (well differentiated = 35.0%, moderately differentiated = 82.0% and poorly differentiated = 94%; exact p < 0.0001) compared to PDAC samples with negative values of IL-13Rα2 (≤ 1+) ( Figure 1 D).
Storage time interactions had significant ( p < 0.01) and highly significant ( p < 0.0001) effects on the syneresis and water‐holding capacity values of the samples, respectively.
The linear regression analysis revealed an extremely significant correlation between the number of stomach items and body length (r 2 = 0.06 and p < 0.0001).
P-value (P) >0.05 was considered as not significant (ns), 0.01< P <0.05 as significant and indicated with one asterisks *, 0.001< P <0.01 very significant and indicated with two asterisks **, 0.0001< P <0.001 extremely significant and indicated with three asterisks *** and P <0.0001 extremely significant and indicated with four asterisks ****.
Two-tailed test of independence indicated that the associations between the mortality and PBO pre-exposure are highly significant (χ 2 = 134.104, df = 1, p < 0.0001).
There was a highly significant statistical interaction between age and residence after adjusting for time from initial diagnosis of CDI to the second episode ( P < 0.0001) ( Table 3 ).
The greater genomic parallelism within than between environments is therefore highly significant ( p < 0.0001).
Expression patterns of hsa-miR-181c and hsa-let-7c KRAS expression exhibited a highly significant, genotype-driven escalation across rs712 and rs9266 variants (p < 0.0001), revealing a clear molecular gradient: WT carriers maintained minimal KRAS expression, whereas HT patients displayed a dramatic surge the highest observed followed by a substantial, though slightly lower, increase in HM.
CCK-8 assays revealed that cell viability showed an increasing trend at 4 mM MgSO 4 ( p < 0.0001; Figure 6a ).
A Spearman's correlation applied to this collapsed data confirmed a highly significant negative relationship (rho = −0.1131, p < .0001).
This strategy showed highly significant differences between FM patients and control subjects (p < 0.0001 and p = 0.0002, for two separate control populations, respectively).
At 7.5 months of age, there was a highly significant difference in the cortex ( p < 0.0001, F (3, 28) = 50.23, Sidak’s multiple comparisons test, Figure 7 A), and similarly—in the hippocampus ( p < 0.0001, F (3, 28) = 23.80, Sidak’s multiple comparisons test, Figure 7 B).
Unpaired t-test showed that there was highly significant difference between patients and controls in age, weight, and BMI ( P <0.0001) only as shown in Table-I .
5C , polyphosphate concentration had a highly significant effect on surface protein concentration (P < 0.0001), which was directly reflected in the marked increase in EAI across all treatments.
There was a highly significant treatment × week interaction on the number of floor eggs produced (F(11,466) = 3.75, p < 0.0001), suggesting that the effect of treatment differed across weeks, and the LSMeans and Standard error for treatment × week interaction are reported in Table 3 and Figure 9 .