This represents an almost five-times enrichment for the presence of the AAAUAA motif in this set of highly expressed transcripts for storage proteins (which is highly significant, with p < 0.0001, according to the one-sided Fisher’s exact test based on a 2 × 2 contingency table) with respect to transcripts not involved in the nutrient reservoir activity (represented by a random sample of 6258 protein-coding genes whose 3′ UTR sequence is identified in rice, which showed a presence of the motif in about 20% of the 3′ UTR sequence).
Excerpts
Variance analyses (data not shown) confirmed great variability among RILs shown by highly significant values of F tests (F value 3.9, 2.4 and 1.82, p <0.0001 for dry and wet seasons and greenhouse experiments, respectively).
In a multilevel model describing HbA1c as dependent variable, the predictor time was highly significant at all time points (p < 0.0001), using time as categorical variable (drop of HbA1c at: Visit 4 = -2.3308, Visit 3 = -2.3583, Visit 2 = -2.0816, Visit 1 = -1.2916) or as continuous variable (drop of HbA1c per time unit = -0.5964).
The correlation coefficient ( r 2) values range from 0.70 to 0.95 (0.70 [for professors], 0.89 [for assistant professors], and 0.95 [for associate professors]); F values are highly significant ( P < .0001) for all faculty subgroups.
Fisher’s exact probability test revealed highly significant ( p < 0.0001) differences between percent distribution of T-patterns containing walking and sniffing in the two groups. 4.
hsa-miR-93 displayed moderate up-regulation ( p= 0.064), while hsa-miR-106b, hsa-miR-221, and hsa-miR-222 exhibited highly significant overexpression ( p< 0.0001 for all).
For Group 1 + 4, the effect of HA condition was highly significant, F (2, 20) = 38.1, p < .0001.
GWAS p -values and R 2 effects were extracted and QTL selection criteria was carried-out based on standard conditions of significance: “highly significant” refers to P < 0.0001 and “significant” refers to P < 0.001.
There was a highly significant positive relationship between year and the proportion of investments made as easements measured both in acres and in dollars ( Fig. 1 ; r 2 = 0.64, p<0.0001; r 2 = 0.54, p<0.0001, respectively).
On the other hand, a highly significant regression was found for V 1 ( P < 0.0001; R 2 = 0.047, Figure 5B ) which is similar to the association of the NGS-58779 SNP marker using the same population structure ( P < 0.0003; R 2 = 0.037, Figure 5D ).
In the anterior ALPS (aALPS), the bvFTD group showed significantly lower values compared to the NC group (bvFTD: 1.24 ± 0.14 vs NC: 1.54 ± 0.12, Cohen's d = −2.2568), with highly significant group differences in all models ( p < 0.0001).
For garden warblers, the positive effect of day on SMI was substantial and highly significant (0.93±0.08, P <0.0001, Table 1 ).
These results were highly significant ( p < 0.0001) compared to MT.
The combination of red LED irradiation with the compounds resulted in a highly significant ( p < 0.0001), dose-dependent reduction in Leishmania promastigote survival compared to the negative control ( Figure 1 B 1 –B 4 ).
The statistical analysis indicated a highly significant result (P < 0.0001), reinforcing the reliability and consistency of our experimental validation.
The relationship between APS2 and composite endpoint was highly significant (p < 0.0001), yet was not significantly different when stratified by age (p = 0.94) or sex (p = 0.337).
In all except one study where the Mendelian disorder was found to be caused by inherited disease variants ( N = 20) [ 51 – 68 , 76 , 77 ], findings were confirmed to be significant using our methods, and in 11 out of 20 studies, P -values were highly significant ( P < 0.0001).
Statistical analysis using Mann Whitney test showed that the differences between control and treated groups were highly significant with P value <0.0001 in all cases ( Figure 6 ).
The median score in the P − group was 20.7 [14.2–28.1] compared to 47.9 [39.1–56.8] in the P + group, a difference that was highly significant (Mann–Whitney U test, p < .0001).
Further, there was an increasing trend in both the proportion of women as senior authors (6% in 2018, 9% in 2019, 14% in 2020, 15% in 2021, and 18% in 2022, P < 0.0001) and percentage of total women authors (9% in 2018, 12% in 2019, 19% in 2020, 17% in 2021, and 20% in 2022, P < 0.0001) across the years ( Figure 2 ).
Similarly, when comparing the mRNA expressions of TGFB2 and TGFB3, TGFB2 showed a highly significant 2.74-fold decrease in mRNA levels ( p < 0.0001) ( Figure S3 ). 3.3.
However, important highly significant risk factors of oocyst shedding of calves was an age of less or equal than 20 days (OR = 7.4; 95% CI 95% = 3–16; P < 0.0001) and occurrence of diarrhea (OR = 5.5; 95% CI 95% = 2–11; P < 0.0001).
Overall, the presence of this fusion transcript represents a highly significant novel association with the SHIP1-deficient phenotype, with a conservatively estimated odds ratio (OR) of 153.0 (95% CI: 5.562–4209, P < 0.0001) compared to the healthy 13 controls, and an OR of 606.3 (95% CI: 22.76–16,150, P < 0.0001) compared to all available SHIP1-sufficient IBD and healthy control subjects ( n = 53).
As shown in Table 2 , highly significant genotypic effects ( P < 0.0001) were detected in both populations in each trial, explaining 54.0–90.4% of the phenotypic variances.
Statistical Analysis All four ALC quadrants were shown to have a statistically significant improvement in visibility between alive and after life conditions ( Table 6 ), with a highly significant overall linear mixed effects model (overall P < 0.0001).