Excerpts

Regression analysis of the qPCR fold-change levels compared to the correspondent microarray results for the 9 genes yielded the following regression line y = 0.775× + 0.206 with a highly significant correlation value of r 2 = 0.999 (Ftest = 6641.86, P < 0.0001).

A possible exception to this may be Peri-G, which demonstrated a highly significant ( P < 0.0001) 2.8-fold increase in pericyte transduction despite having only two substitutions (K527G and E531G) in VR VII.

The difference in incidence of GCaMP expression in Cre-expressing and Cre-lacking neurons is highly significant ( p < 0.0001; Fisher’s exact test). 10.1523/ENEURO.0373-21.2022.f7-1 Extended Data Figure 7-1 Cre-dependent expression is limited to peripheral neurons.

There was a strong and highly significant correlation between TSS in the EEC and TSS for subjects spending > 3 h outdoors (r = 0.51, p < 0.0001).

Restricting the analysis to the five populations sampled within Ryder Bay, global F st was lower (0.0181) but still highly significant ( P <0.0001), indicating the presence of fine-scale population genetic structuring.

For GF1 cells (Figure 3a ), the highest (M‐PM crystal, 1.236 ± 0.312) and the lowest (Therapon Transpa, 0.813 ± 0.160) relative cell viability were found within the group of milled resins, and their difference was highly significant ( p < .0001).

The Cochran-Armitage trend test showed an increasing trend in infection rate with increased age in all four years’ national surveillance ( P <0.0001).

The differences between species richness in NW and RB were highly significant ( P < 0.0001).

Pearson’s chi-square test revealed a highly significant difference between groups ( χ 2 (2) = 60.0, p < 0.0001), and Fisher’s exact test was also performed and confirmed the statistical significance of the association ( p < 0.0001).

Significance values are denoted by asterisks as defined by GraphPad Prism version 6.04: ****extremely significant (p < 0.0001); ***extremely significant (0.001 ≤ p ≤ 0.0001); **very significant (0.01 ≤ p ≤ 0.001); *significant (0.05 ≤ p ≤ 0.01).

Equation (5) was extremely significant ( p < 0.0001) and the model was ideal ( F = 29.86).

Similarly, at 25 μg/mL (gluten coated IC50), a highly significant difference (P-value ≤ 0.0001) is noted compared to sericin-coated particles, accompanied by a 40% reduction in cell viability.

Statistical significance is indicated in the figures by asterisks, using the following standard notation: * for p ≤ 0.05 (significant), ** for p ≤ 0.01 (very significant), *** for p ≤ 0.001 (highly significant), and **** for p ≤ 0.0001 (extremely significant).

Two-sample t test showed highly significant group differences ( p < 0.0001) for all measures in both striatal regions ( Table 2 ).

This decrease ( Figure 2 ) was highly significant compared to WT ( p < 0.0001) and was not significantly higher than the background switching at time zero ( p > 0.9999).

There was a highly significant interaction with age (p < 0.0001), such that the association was only observed for younger compared with older individuals: HR 1.27 (1.15-1.39) and HR 1.00 (0.92-1.09) in individuals ≤75 years and >75 years, respectively.

In particular, the difference was highly significant in the case of ALS (controls: 9098.68 ± 1210.76 pg/mL; ALS: 17,235.3 ± 1033.2; p < 0.0001), and AD (18,496.00 ± 1165.27; p < 0.001) and less in the case of ID (16,180.35 ± 1323.65; p = 0.004).

Our results are consistent with those reported elsewhere, indicating reduced low back pain (VAS score) in 75% and reduced disease activity, which is clearly significant during the first 2–3 months and is maintained at ∼6 months according to the VAS score (−3.25, P < 0.0001), BASDAI (−1.86, P < 0.0001) and ASDAS (−1.0, P < 0.0001).

This difference was considered extremely significant (U = 3; U′ = 172, p value < 0.0001). 3.3.

Other Clinical Efficacy Results The mean changes from baseline in the IKDC subjective score, which ranges from 0 (worst result) to 100 (best result), were highly significant at all time points (i.e., P < 0.0001; including Month 3) and increased in their extent through Month 24 (LS mean increase from baseline: 41.6 ± 1.9 points; 95% CI: 37.9-45.4).

Comparison of the IHC and single-plex immunofluorescence revealed highly significant positive correlations between the cell densities of CD8, CD68, CD16, PD-L1 and SOX10 marker positive cells (Spearman’s rho = 0.927 to 0.750, p < 0.0001).

A Mann-Whitney log rank test was performed, which demonstrated a highly significant difference between the predicted probabilities of the healthy donors, nonirradiated patients, and the irradiated patients ( p < 0.0001).

Among 48 cytokines/chemokines, evaluated by multiplex analysis in patient plasma, 6 (IL-6, CXCL-10, HGF, MIG, MCP-1, and G-CSF; Supplementary Table S2 ) were identified as highly significant in COVID-19 patients compared to non-COVID-19 respiratory disease controls ( p -value < 0.0001) ( Figure 2 ).

The Kaplan-Meier curve indicated that the difference between the high-and low-risk score subgroups was highly significant ( p < 0.0001) ( Figure 2F ).

The mean GI score in CHX group was found to be 0.70 ± 0.25 as against 0.66 ± 0.16 in Hi-Ora and 1.59 ± 0.55 in normal saline groups indicating least GI scores in Hi-Ora group while the results were found to be statistically highly significant ( P < 0.0001).