We therefore re-analyzed the genome-wide expression profiles (Gene Expression Omnibus accession number GSE21260 ) of several different uninfected KC cultures and hrHPV+ KC cultures reported previously [10] by Ingenuity Pathways Analysis (IPA) and found a highly significant enrichment of genes belonging to the protein ubiquitination pathway ( Table S1 ; p = 6.69×10 −5 ).
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At the group level, the ΔPSEs were highly significant for the ASD group (red bar, Figure 2B ; t 17 = 5.2, p = 6.7∙10 −5 , Cohen’s d = 1.23, 95% CI = [0.6, 1.84], t -test), and smaller, but still (albeit marginally) significant for the control group (blue bar, Figure 2B ; t 19 = 2.1, p = 0.047 Cohen’s d = 0.47, 95% CI = [0.006, 0.93], t -test).
Some of the CpG sites with nominally significant (p<6.7×10 −5 ) differences in methylation between HA and LA are close to genes that are differentially expressed in response to hypoxia; these genes include: toll-like receptor 6 ( TLR6) [57] , mif two 3 homolog 1 ( SUMO1) [27] ; phosphodiesterase 4A ( PDE4A) [58] and human immunodeficiency virus type I enhancer binding protein 2 ( HIVEP2 ) [42] .
Lastly, comparison of all MS patients with HC showed a highly significant decrease of MMP3 ( P = 6.77 × 10 −5 , q = 0.067) in MS subtypes compared to HC (Fig. 5 & Table 3 ).
explains 13.67% of variation in , the spread of the early rings, and is highly significant (p = 0.000068) while explains more variability at 19.01% but was much less significant (p = 0.0593).
p -values were Bonferroni-adjusted for multiple comparisons, with associations deemed potentially causal at p < 0.05 and highly significant at p < 6.8 × 10 −5 .
More recently, whole-genome sequencing revealed a highly significant ( p = 0.000068), abnormally high proportion of pathogenic MYH6 variants observed in 197 patients with HLHS (vs. 813 controls) [ 13 ].
In the large group of muscle-enriched exons studied here, we found a highly significant correlation of ugcaug frequency with muscle expression ( P = 6.8 E −05).
There was a highly significant correlation of the raw RNA output (R = 0.99, p- value = 6.9e-5), demonstrating inter-assay concordance.
In particular, the top nine pathways (most highly significant (p< 6.93e-05) were: microRNAs in cancer (hsa05206), endocrine resistance in cancer (hsa01522), EGFR tyrosine kinase inhibitor resistance (hsa01521), FoxO signalling pathway (hsa04068), hepatitis B (hsa05161), pathways in cancer (hsa05200), proteoglycans in cancer (hsa05205), breast cancer (hsa05224) and human papillomavirus infection (hsa05165).
Across all tumor types, there was a similar range of cell viability when comparing Collagenase I and Collagenase IV, with mean viabilities of 25.18 ± 6.23% and 66 ± 15.51%, respectively, demonstrating highly significant differences ( p = 0.00007; pairwise Wilcoxon rank-sum test).
Correlation between PD and PDR performance We found a highly significant, positive correlation (Spearman's rank correlation, r = 0.72, p = 0.00007) between the individual performances in the PD and PDR tasks, i.e. subjects that needed a high number of trials to reach the criterion in the visual discrimination task also needed a high number of trials to reach the criteri
The expression difference between VIGS and control plants was highly significant in a two-tailed Student's t -test of 2 ΔCt values (VIGS 0.1 ± 0.05; Untreated 0.53 ± 0.01, p -value = 7 × 10 −5 , Figure 3Bb ).
3 ; Additional file 9 ), a highly significant expansion was found on the branch leading to Euascomycetes (p = 7 × 10 -5 ).
Results The SNP rs1635529 for COL2A1 on 12q13.11 showed highly significant over-transmission to affected individuals (p=0.00007).
Statistical analysis confirmed that the AMP+ATZ combination was highly significant ( p = 0.00007) compared to the ATZ-only treatment, demonstrating the synergistic interaction between AMPs and ATZ.
An extremely significant increase was detected throughout the day’s 14 ( P = 0.00007, 0.0001, and 0.0008) and day’s 28 ( P = 0.000, 0.000, and 0.0001) of period studied in all present treated groups (Pro 4, Pro 7 and mixture of Pro 4 and Pro 7 strains respectively) compared to untreated group.
As an illustration, taking a case with 5 TDLU with negative staining, 5 of sporadic pattern at intensity 2, 5 of sporadic pattern at intensity 3 and 10 with a 'ring-like' pattern at intensity 1 results in a score of 20 x 0 + 20(2 + 1 + 1) + 20(3 + 1 + 1) + 40(1 + 2 + 1) = 340 Twenty-five cases were examined independently by two observers and the scores obtained showed a significant con- cordance (t = 0.723, P = 0.00003, Kendall Rank Correlation). Intraobserver correlation was also highly significant (T = 0.96, P = 0.00007).
A 2-tailed P < 0.05 for validation tests with FG and FI was considered nominally significant, and after the Bonferroni correction for multiple comparisons, P < 7E-05 for FG and P < 5E-04 for FI were considered statistically significant.
In line with the Kaplan–Meier analysis, cf-miRNA levels were highly significant for OS in both univariate (HR 1.89, P = 0.00007) and multivariate (HR 1.83, P = 0.001) analysis (Fig. 1c and Supplementary Table 1 ), confirming that total cf-miRNA is an in the independent prognostic marker for survival in OC.
A Smirnov-Kolmogorov test evaluating the difference between the empirical distributions and the straight line gives a highly significant result, p = 0.00007 in the case of maxima (panel B), and p = 0.006 in the case of minima (panel C).
This highly significant oxidation of the cytosol (p value = 7 × 10 -5 ) is dependent on NOX2 activity, but independent of the most effective thiol oxidant produced in neutrophils, MPO-derived HOCl.
The association findings for these three genes using other methods (O’Brien with GATES and TATES with GATES) are also moderately significant ( P < 7.0 × 10 −5 ), except for MultiPhen with GATES ( P < 0.01).
The difference between the two groups was considered highly significant, as the sum of chi square values comparing the two groups was 19.07 and p = 0.00007.
Data 4 ), which represents a highly significant intersection ( p = 0.00007, hypergeometric test).