Excerpts

In comparison to the most common haplotype 1112, fasting insulin levels and HOMA-IR values of haplotypes 1221 and 2221 were significantly higher and lower, respectively ( Table 1 ), and the difference between 1221 and 2221 was highly significant ( P = 0.00006).

After repacking of modeled structures, which led to structural fitting of contacting residues and displacement of their side-chain groups, the correlations of steric descriptors became weaker, while the correlations of hydrophobic descriptors still remained highly significant (p-value = 6x10 -5 ). 3.4 Identifying residue binding features in CDR3: peptide interface using machine learning At the final stage we performed RFE (Recursive Feature Elimination) analysis and applied the Random Forest (RF) algorithm to make predictive models for the per-residue contacting energy values for amino acid residue pairs in CDR3 loops and peptides.

All seven SNPs of the CEP68 gene showed linkage disequilibrium (LD), and the haplotype of CEP68_ht4 (T-G-A-A-A-C-G) showed a highly significant association with aspirin intolerance (OR = 2.63; 95% CI = 1.64–4.21; P = 6.0×10 −5 ).

Similarly, highly significant diabetes cis- and trans-acting eQTL-SNPs were identified ( p < 6.0 × 10 −5 and p < 6.0 × 10 −5 , respectively; Supplementary Spreadsheet 2 doi: 10.17608/k6.auckland.5285041 ).

Three such modules (red, ivory, and light yellow) showed highly significant correlation with the MeJA treatment (Pearson r = 0.75—0.88; p = 6.04E−05–2.03E−09; Fig. 6 A; Supplementary Table S7 ).

Deleting or duplicating sleep risk genes is associated with autism risk Pooling the MSSNG and SSC datasets yielded highly significant enrichment of insomnia risk (OR = 1.7, 95% CI = 1.5–2.0, p = 6.1 –05 ) and circadian pathway deletions (OR = 4.0, 95% CI = 3.4–4.6, p = 1.3 –05 ), and circadian duplications (OR = 1.8, 95% CI = 1.5–2.1, p = 4.4 –05 ), in ASD compared to controls (see Fig. 3 and Table S6 ). 95% CI of these ORs obtained by bootstrapping confirmed these results (Table S6 ).

Highly significant MTAs (P < 0.000061) under heat stress conditions were identified for flag leaf area ( xwmc336 ), spikelet per spike ( xwmc553 ), grains per spike ( cxfa2147 , xwmc418 and xwmc121 ), biomass ( xbarc7 ) and grain yield ( xcfa2147 and xwmc671 ).

However, after controlling for the single-gene effect, the partial correlation between TCL and cancer risk is still highly significant (Spearman’s ρ = −0.69, P = 6.10 × 10 −5 ; fig.

This led the authors to assign scores of very low quality despite highly significant indications of efficacy of LOLA (RR 0.70, 95% CI 0.59, 0.83, Z = 4.01, p < 0.000061).

The improvement from geno2pheno-C Sanger to geno2pheno-C NGS–Sanger + was highly significant ( p -value = 6.22e – 05), while it was only significant at significance level α = 0.11 or higher for the improvement from geno2pheno-C Sanger + to geno2pheno-C NGS–Sanger + ( p -value = 0.11).

The proportion of direct target genes misregulated in fd-3 seedlings is highly significant according to the one-sided Fisher’s exact test (p = 6.257 × 10 −5 ).

The results obtained show that the differences are highly significant for genes ORF1ab ( p = 6.291 × 10 −5 ) and N ( p = 0.00329), while for gene E differences are only close to significance ( p = 0.0672).

Considering IC 50 value, NHFMEWF (156.32 ± 1.32 μg/mL) was estimated to be just around 50% less potent than that of acarbose (103.77 ± 1.02 μg/mL) in inhibiting α-amylase, which was also analyzed to be highly significant ( p = 0.000063) in contrast to the acarbose.

Our analyses show that the linear relationship between the two variables is highly significant (b 1 = 4.65; F (1,10) = 43.2; P = 6.3 × 10 -5 ), with a determination coefficient for b 1 of R 2 = 0.78.

In contrast, a highly significant difference was observed in adenocarcinoma growth patterns ( p = 6.30 × 10 −5 ).

This implies 5.3-fold highly significant (p = 6.3×10 −5 ) excess of the observed associations compared to those by chance.

the lesion) with HYV frequencies ranging from 60–63%, all of which are highly significant ( P < 6.3e-5; Figure 4B ).

While pathway analysis did not identify any canonical pathways to a high level of significance, chemotaxis of eosinophils was identified as a highly significant function ( P = 6.4 × 10 -5 ) (see Additional file 7 ), and eosinophil levels correlated well with RNAs for all of the aforementioned chemokines and cytokine (see Additional file 11 ).

11 and 12 ) and approached significance with percent glycated albumin ( P = 6.4 × 10 −5 ) and total glycated albumin ( P = 2.0 × 10 −6 ) ( Table 2 ). rs2438321 was not associated with HbA 1c in blacks and was not associated with any of the markers of hyperglycemia in whites independently or in a meta-analysis across ancestries ( Tables 1 and 2 ).

We observed highly significant excess of CD missense URVs in EE/DEE (Fig. 1a , P = 0.0000643, OR = 1.09), whereas there was no significant excess of the other missense/inframe URVs ( P = 0.0861, OR = 1.01).

More specifically, the associated marker IAAV416 of QLyc.sxau-7A.2, located at 712.42–713.74 Mb, exhibited a highly significant level (− log 10 ( P -value) = 4.19–6.86), indicating the presence of genes that regulate lycopene at these loci (Table 2 ).

A single marker in FGF20 becomes nearly statistically significant ( P = 6.47 × 10 −05 ) when using only pathologically confirmed DLB cases.

Both 2361.8560 m/z and 2528.8833 m/z remained highly significant ( p = 6.57 × 10 −5 and 1.1 × 10 −5 , respectively) indicating that loss of these structures is associated with loss of gland differentiation in early stage PCa.

Several of the genes that showed RpoN-dependent expression in root nodules also contained a highly significant ( p -value ≤ 6.58 × 10 −5 ) RpoN binding sequence in their promoter region: the promoter of Bphy_0256, coding for nitrogen regulatory protein P-II ( glnB1 ), which is localized upstream of the ammonium transporter gene ( amtB ) ( Figure 3 A, Table 3 ); the promoter of the glutamine synthetase encoding gene (Bphy_1481, glnA ); followed by two genes of the 2CRS NtrBC ( Figure 3 B), which were also present among the 322 top down-regulated genes.

The divergence within each group is not statistically significant (divergence within CQS subsets Wilcoxon test, P = 0.35- Figure 2 C; within CQR subsets Wilcoxon test, P = 0.43- Figure 2 D), while the divergence between the groups is highly significant (Wilcoxon test P = 6.61 × 10 −5 , Figure 2 A and B).