Excerpts

The differences were found to be highly significant ( t -test, p < 0.00001).

Figure 7 a shows the relationship between LAI r and LAI-vc e by applying method (ii) with k r obtained by inverting Equation (7), which rendered highly significant statistical analysis ( Table 4 ) as expected ( R 2 = 0.94; b = 0.98; SEE = 0.71; RMSE = 0.15; p < 0.00001).

We found a highly significant increase in the KEGG and REACTOME cell cycle pathway enrichment scores (both p < 0.00001), supporting the cell cycle phase analysis results (Fig. 4c ).

This overlap is highly significant ( P -value < 1e-5), especially given that Met4 ChIP-seq only shows 45 peaks throughout the entire genome.

Similarly, when anxiety was assessed using the SAS, CBT demonstrated a stronger and highly significant effect (MD = −6.22; 95% CI −7.63 to −4.80; P < 0.00001), also with no heterogeneity ( I 2 = 0%).

This difference was highly significant (t = 10.35, p < 0.00001).

The results of the analysis indicate that the decrease in grip strength level after being diagnosed with sarcopenia is extremely significant [MD = -7.32; (95% CI, -10.42 ,-4.23); P < 0.00001; I 2 = 93%] (Fig. 4 ), which is the most direct and significant clinical manifestation of sarcopenia.

The subjects’ own educational attainment showed a nominally significant negative association with F roh ( p = .045), while the contribution of parental education to offspring F roh was highly significant (father: p < 10 -5 ; mother: p = 9×10 -5 ), with more educated parents having offspring with fewer ROHs.

Obesity was associated with a slight but highly significant increase in odds of having RA compared with normal weight (OR = 1.11, CI 1.06–1.16, p < 0.00001), with a high heterogeneity across studies ( I 2 = 74%, p = 0.009) (Figure 2A ).

Subgroup analysis in smaller subgroups of patients, who were consistently AF/AT free (n=140 in PAF group, n=72 in LSPAF group) or consistently non–AF/AT free (n=48 in PAF group, n=28 in LSPAF group) across all annual assessments ( Figure 3 ), showed that baseline–to–3‐year improvement in QoL was highly significant in AF/AT‐free PAF and LSPAF patients (EQ‐5D: 9.6±14.4 and 10.4±12.8; EQ‐VAS: 7.0±14.5 and 11.5±13.5, respectively; all P <0.00001).

Four of the 142 sequenced genotypes were identified as outliers along four different and highly significant axes of variation ( P < 10 −5 from tests based on the Tracy–Widom distribution) based on the default settings of the smartpca program within the EIGENSOFT package ( Patterson et al. , 2006 ).

The regression through the origin of PIC %mC on PIC logCvalue was highly significant (adjusted R 2 = 0.376, F 1, 40 = 25.66, p = 0.00001).

This difference between TLE subtypes was highly significant (p < 10 −5 , randomization test).

In all cases, the computed correlation coefficients turn out to be very highly significant ( p < 0.00001).

Among the biological functions that showed highly significant (P < 0.00001) changes in fast muscle in response to exercise were muscle development, myogenesis, angiogenesis, cell cycle progression, mitosis, cytoskeleton organization, lipid oxidation, lipid synthesis and organismal growth (Additional file 2 : Table S2), with 143, 59, 230, 408, 172, 424, 81, 240 and 201 differentially expressed genes, respectively.

Estimation of the SNP effect from the haplotype effect Under the hypothesis that one SNP of each haplotype was expected to have a major effect on the recorded trait, direct observation of those haplotype alleles that showed a highly significant effect (P < .00001) on one trait allowed to select one SNP where the two alleles showed opposite effects on that trait.

The addition of DEX significantly decreased the onset time of anesthesia of nerve blockade by an average of −48.78 s in comparison to the control (95% CI: −64.22 to −33.35; I = 95%), favoring DEX, with a highly significant overall effect (Z = 6.20, p < 0.00001) (Fig. 3 a).

For the third most significant genotyped loci, located on chromosome 8 in the vicinity of the ZNF704 gene, borderline significance was achieved ( P <10 −5 ).

Statistical analysis confirmed that the deviations from population norms were highly significant for the overall group (N = 123, p = 0.00001), as well as separately for girls (N = 59, p = 0.00001) and boys (N = 64, p = 0.00001).

Overall, highly significant PFS was achieved with ALK inhibitors compared to chemotherapy (HR 0.42 [0.35, 0.50; p < 0.00001]) (Figure 2 ).

[ 32 ] led to highly significant heterogeneity ( p < 10 −5 and I 2 = 94 %); consequently we excluded this study from the meta-analysis.

This comparison identified 3,487 differentially expressed genes (DEGs) that met a fold change cut-off of >2 with a highly significant, Bonferroni corrected pvalue (p < 0.00001).

Highly significant (P < 0.00001) pairwise correlations were observed for 431 out of the 703 possible pairs for the 38 probesets examined in this study.

Increasing the ultrafiltration volume or dialysate flow led to a highly significant increase in IL-1ra and IL-6 clearance rate ( P < 0.00001).

These studies had highly significant heterogeneity ( P < 0.00001, I 2 = 91%), so a random-effect model was used to calculate pooled SMD.