Excerpts

In the three effect model, SNP rs1048943 (CYP1A1 G/A) all demonstrated the highly significant association with cervical cancer (All p values < 0.00001).

Correlation analysis across six independent bulk transcriptomic cohorts (TCGA-PAAD, ICGC-PAAD-CAseq, GSE85916 , GSE79668 , GSE71729 , and EMTAB6134) demonstrated a highly significant positive association between THBS2+ CAF signature scores and T-cell exclusion scores (all p < 1 × 10−5), indicating that tumors with high THBS2+ CAF infiltration exhibit restricted T cell access to tumor nests ( Fig. 4 B).

One group was enriched 20–30-fold relative to the GST negative control, with highly significant P -values ( P < 1 × 10 −5 ).

Although Pd-MOF produced a highly significant downregulation of VEGFR2 gene expression in A549 cells compared with the untreated control ( p < 0.00001; Fig. 7 D), its inhibitory potency remained considerably weaker than that of the reference drug, sorafenib.

This comparison identified 3,487 differentially expressed genes (DEGs) that met a fold change cut-off of >2 with a highly significant, Bonferroni corrected pvalue (p < 0.00001).

These studies had highly significant heterogeneity ( P < 0.00001, I 2 = 91%), so a random-effect model was used to calculate pooled SMD.

Highly significant (P < 0.00001) pairwise correlations were observed for 431 out of the 703 possible pairs for the 38 probesets examined in this study.

Nevertheless, a highly significant correlation (Pearson’s correlation coefficient R = 0.968; p < 0.00001) is observed between the frequency of usage of an ataxin-3 amino acid site as a binding site in the two datasets.

There is a highly significant correlation of the expression levels of individual ta-TRIM s as determined from EST and from RNA-Seq data (Pearson correlation test, P < 0.00001), confirming that the variation observed among ta-TRIM s is not an artifact of the mapping algorithm or the selected parameters.

0.065), with highly significant differences (profanity Mann-Whitney U p < 10 − 5 , insult Mann-Whitney U p = 0.00034 ).

There was no significant difference in MM96L when siNF1 was compared with miR-514a, whereas in MM253, particularly at higher drug dosage (10-100nM), the differences between siNF1 and miR-514a, were highly significant ( p < 0.00001) (Figure 5a ), indicating that the mode of BRAFi resistance was different, possibly due to other targeted genes of miR-514a.

When 29 studies containing 4,390 patients who had received radical surgery (I–III) were considered, highly significant heterogeneity was detected ( χ 2 =92.48, P <0.00001; I 2 =70%).

Though the differences were small, particularly on the original task, they were highly significant (P < 10 −5 ).

Heterogeneity analysis revealed highly significant heterogeneity (I 2 = 93%, p < 0.00001), thus a random-effect model was used for statistical analysis.

The main effect of the post-error was highly significant ( F (1,37) = 204.6; p < 0.00001) indicating that response time increased after errors in a stop trial (Fig. 3a : the difference between the after-error and after-correct trials).

The χ 2 results show that likelihood ratio statistics are highly significant ( P < 00001) suggesting that the model has a strong explanatory power.

The main factor Language was highly significant, F (1, 33) = 98.69, p < 0.00001, reflecting the overall better performance of Tashlhiyt than French participants.

A highly significant association (p < 0.00001) was found between the trend of menstrual products used by the participants and their monthly income/capital to maintain their livelihood (Table 2 ).

Pre-saturation of EGFR on A431 cells with an excess of both non-labeled ZEGFR:2377 and cetuximab caused a highly significant (P<1×10 −5 ) reduction of 89 Zr-DFO-Z EGFR:2377 binding to the cells.

Inter-rater reliability was highly significant (Cohen's κ = 0.62; Z = 19.1; P << 0.00001; number of errors = 90).

The addition of DEX significantly decreased the onset time of anesthesia of nerve blockade by an average of −48.78 s in comparison to the control (95% CI: −64.22 to −33.35; I = 95%), favoring DEX, with a highly significant overall effect (Z = 6.20, p < 0.00001) (Fig. 3 a).

Effect of SR on HR Figure 2 shows that the effect of SR is highly significant, although clinically small: 1.65 bpm [95%CI: 1.19, 2.11], p < 0.00001, random effect, or 1.40 bpm [95% CI: 1.05, 1.75], fixed effect.

For Experiments I & II, we selected units with a split-half correlation of at least 0.1, where this correlation was highly significant (p< 10 −5 ).

However, the highly significant differences in sputum conversion ( P <0.00001) corresponded to only slight differences in the conversion rates (86.6% vs. 84.3%).

The results showed that the effect size of connectivity difference remained highly significant: BNM—L Precentral Gyrus ( p < 0.00001); BNM—R Precentral Gyrus ( p < 0.00002); LC—Cerebellum ( p < 0.000001); LC—Hippocampus ( p < 0.0004); VTA/SNc—Cerebellum ( p < 0.000001); VTA/SNc—Putamen ( p < 0.0012); and VTA/SNc—Left MOG ( p < 0.0010).