Excerpts

The depicted IBD segment in Figure 3 has a highly significant IBD score ( P -value < 1E-5).

In the ACS patients, the bleeding rate showed a highly significant difference between the short DAPT vs . standard DAPT, with a risk ratio 0.59 (95% CI 0.47-0.74; z=4.56, p=0.00001) (Fig. 4A ).

Seven other RSA traits were modified in both IL99 and Ruta reflecting the common response to LN (Figure 3a–g ) but showed a highly significant change in IL99 ( p < 0.00001) and lower significance in Ruta, including maximum number of roots*, number of root tips, total root length*, network area*, volume, surface area, and holes* (i.e., traits marked with* were advantageous in IL99 over Ruta under the LN treatment (Figure 3a–g ).

When comparing each variable (GI35, GI42 and DTF) between years (Figure 2b–d ), highly significant correlations were observed ( P < 0.00001) supporting a strong genetic control of these traits.

The unpaired Student’s t-test revealed a highly significant difference in PNP biodegradation between the compared conditions, with a p-value < 0.00001, indicating statistical significance well below the 0.01 threshold.

The genotype × harvest season interaction was highly significant (Fg × hs = 4.00, p < 0.00001), indicating the presence of clones with distinct yield performance over time ( Figure 1 ).

The dF/S analysis revealed a highly significant enhancement of syx-GFP cluster formation of over 60% by vSyx (p < 0.00001, Fig. 2D ).

These changes correspond to a highly significant ( t (44) = 5.10, p < 0.00001) decrease in average FA in the white matter between left thalamus and left IPL (Figure 2B ).

The STRING (Search Tool for the Retrieval of Interacting Genes/proteins) functional analysis of DAPs during the 8–12 cell-to-morula transition confirmed the highly significant enrichment in the ribosome, spliceosome and RNA transport pathways (p-values < 10 −5 ; see all enriched terms during the 8–12 cell-to-morula transition in Supplementary Table S5 ).

Increasing UF volume or dialysate flow led to a highly significant increase in IL-1 receptor antagonist and IL-6 clearance rates ( P < 0.00001).

The difference was highly significant (p < 0.00001), indicating that surgery provides faster and better functional recovery.

Combined immunotherapy and antiangiogenic therapy also showed a favorable trend compared to Sunitinib regarding objective response rate (OR=2.53 (2.23, 2.87), P < 0.00001) (Figure 4 ).

The deviation from Hardy-Weinberg equilibrium is highly significant ( P < 10 −5 , Fisher’s Exact Test 40 ) with a complete absence of heterozygotes.

The combined group demonstrated a substantially larger and highly significant positive effect (SMD = 2.02, 95% CI: 1.83 to 2.21; P < 0.00001).

Variants were thus discarded if: (i) UCSC alignability ≠ 1 (100bp window size); (ii) variant within 10 bps of a simple repeat region; (iii) highly significant deviation from Hardy-Weinberg equilibrium (HWE) in cases or controls ( P <10 −5 ); (iv) no call rate significantly different between case-samples and control-samples ( P <10 −5 ); (v) no call rate across either case or control samples >0.03.

Among the top most highly significant pathways ( P < 1.0 × 10 − 5 ) included the pathways involved in MSP-RON, PDGF, molecular mechanisms of cancer, STAT3, prostate cancer, P53, MYC mediated apoptosis, IGF-1, NF-kB, Androgen biosynthesis, PTEN and IL-6 signaling pathways (Fig. 5 ).

The linear-regression analysis between the number of CAG repeats in the expanded allele and age at onset was highly significant ( p < 0.00001).

These data demonstrate a high degree of gene expression dysregulation in the peripheral blood of patients with FA with a highly significant ( P < .00001) skewing in favor of upregulated genes.

The correlation between various stages of OSMF with SOD (per/ml) and MDA (nmol/dl) by Spearman's rank correlation method indicated a significant ( P = 0.0010) moderate inverse relationship between various grades of OSMF with SOD as Spearman R (r s ) was 0.5700 and a highly significant ( P = 0.00001) direct strong relationship between various grades of OSMF with MDA as Spearman R (r s ) was 0.6725 [ Table 4 ].

Comparing the proportion of stage I PDACs to the national average is highly significant; in 2016, 5.4% of 8,398 PDACs in the SEER database (National Cancer Institute-SEER) were stage I by surgical pathology ( P < .00001, Fisher's exact test). 3 Seven of the nine patients diagnosed with a screen-detected PDAC are alive, with median overall survival to date of 3.84 years.

Moreover, the fluorescence intensities standard deviations differences between the groups were highly significant (W = 56,296, p -value < 0.00001; Fig. 3 b).

There was significant differences in adiponectin serum levels between treated groups and nontreated group (control), this difference was highly significant between omega-3 fatty acid and rosuvastatin plus omega-3 fatty acid ( P = 0.00001), whereas less significant between rosuvastatin and rosuvastatin plus omega-3 fatty acid-treated group and insignificant between rosuvastatin and omega-3 fatty acid-treated group [ Table 4 ].

The analysis identified 21–34 highly significant SNPs (− log 10 P > 5), with an estimated total heritability of 37.31–62.34%, while large contributions to variations was due to dominance, dominance-related epistasis, and environmental interaction effects ( h D + 2 = ^ 14.06% ~ 49.28%), indicating these factors contributed significantly to phenotypic variations of the ear traits.

The overall Pearson correlation between the Caprini and Padua scores was only moderate, albeit highly significant (r = 0.619, p < 0.00001).

Peripheral calcifications showed highly significant differences between subtypes ( p < 0.00001).