Excerpts

The most statistically significant SNPs associated with late toxicity are listed in Table 5 , Table 6 , Table 7 , Table 8 , which show several SNPs had meta-p-values reaching or approaching significance (p-value ≤ 5 × 10 − 6 ) with concordant effect direction across the individual studies.

Time-wise comparisons were all highly significant ( p = 5×10 −6 *, each based on 8 replicate experiments).

These correlations were still highly significant within the AM group (all 3 r ’s ≥ 0.55, all 3 P -values ≤ 5.0 × 10 −6 ).

The breed ages were then plotted against the proportion of deleterious SNPs ( δ ) and a highly significant negative correlation was observed (Pearson r = − 0.86, P = 0.000005) (Fig. 2 ).

It was shown that Kiruhura was getting very highly significant (t = 20; P = 0.000005, df = 21) more total household income than Isingiro.

Mixed effects models were employed to evaluate the rate of change in Mini‐Mental State Examination scores as a quantitative measure of disease progression Results Variants on chromosome 22q12.1 mapped to ZNRF3, MN1, PIPNB genes reached genome‐wide significance and together with nominally significant loci ( p <5×10−6) highlighted a role for neuronal resilience (both excitatory and inhibitory neurones) and anti‐viral immune responses.

Since the sample size of personality was not large enough, to get more SNPs, all the exposed genetic IVs were identified at least borderline significance ( p < 5 × 10 −6 ) 25 , and clumped at the threshold of linkage disequilibrium (LD) ( r 2 < 0.001 within 10,000 kb).

Paired t-tests confirmed these differences as highly significant ( p < 5 × 10 −6 ).

This ancestry effect was also highly significant in the replication cohort ( n = 2011; P = 5 – 6 ).

All comparisons were highly significant after Bonferroni correction ( P < 5 × 10 –6 , Wilcoxon signed-rank test).

Saturation of PSMA with a large excess of unlabeled compound causes a highly significant (p< 5 x 10 -6 ) reduction of binding of each labeled compound to cells, which demonstrates the saturable character of their binding ( Figure 3 ). 3.3.

Haplotype-based association analysis confirmed the single SNP analyses, and global p-values for association between TRPV1 haplotypes and cough were highly significant (p < 5 × 10 -6 ).

Results were considered genome-wide significant at p < 5 × 10 −8 , and suggestive of significance at p < 5 × 10 −6 .

There was a highly significant difference between the PA and SD patients on this measure, t (18) = 6.87, p < .000005, one-tailed.

Rank correlations were marginally higher for men than for women and higher after in situ than after invasive SCC, all correlations were highly significant (P~5×10 −6 ).

At age 7, asthma control test scores showed a highly significant difference between children with and without asthma ( p = 5.0 × 10 −6 ), as expected, but no significant difference (Fisher's Exact Test, p > .05) in spirometry (FEV%) or medication with leukotriene receptor antagonist (LTRA) or inhaled corticosteroids (ICS) the 24 h preceding any of the visits was observed.

Region of interest (ROI) analysis confirmed a highly significant decrease in PE values in Met 158 -, compared to Val 158 , homozygotes (F 1,53 = 34.0; p < 0.000005; Fig. 2 , which was unaffected by the inclusion or exclusion of age as a covariate).

Nominally significant loci ( P < 5 × 10 −6 ) were followed up for candidate gene mapping.

However, the M1 protein VGF was only nominally significant at classifying AD in Caucasian AUC = 0.6030 ( p = 0.0406, CI = 0.4887–0.7173), yet highly significant in African Americans AUC = 0.7593 ( p = 5.03e-06, CI = 0.6634–0.8552).

Three highly significant ones, QLB1 ( p = 5.03E−06), SNP4036 ( p = 1.81E−07), and SNP0024 ( p = 6.66E−06) had PVE values ranging from 19.23% to 31.80% and they are located on chromosomes 3H at 612 Mbp, 5H at 40 Mbp and 7H at 18 Mbp, respectively.

At the highest dose employed, both vectors promoted a highly significant reduction in NAA relative to sham controls, with a 2.6-fold reduction in AAV/Olig001-ASPA brains (p = 5.06 × 10 −6 ) and a 2-fold reduction in AAV9-ASPA brains (p = 1.97 × 10 −6 ).

Additionally, there was a highly significant SNP (tagged to q13, P = 5.1e-06) for the full panel on chromosome 11, which accounted for 12.4% of the phenotypic variation for RWC_T1.

The KS statistic is highly significant with the chance of a random compound association beating the enrichment maximum of p = 5.1E−6.

The Mantel–Cox log rank test gave a χ 2 value of 32.325, which suggests a highly significant difference in the survival rate between the 6 study groups (P=5.1233 E-6).

We found highly significant SNPs in ABCC2 , a known carboplatin transporter, associated with carboplatin clearance (asymptotic P = 5.2 × 10 6 , empirical P = 1.4 × 10 −5 ), indicating biological plausibility.