Excerpts

A SNP in Sema-1a (2L.8630728) was very on the brink of significance on the high glucose diet ( p = 1.42 x 10 -6 ) and nowhere near our significance threshold on the low glucose diet ( p = 0.001).

Also, the level of education of the clients had a strong statistical association with the pattern of their substance use, i.e., differences in the proportion of mono- and poly-drug users clients for different levels of education was highly significant (p=0.00000144).

Unlike our highly significant findings, where adjusted R2=0.610 and p= 1.45E-06, Kumar et al “did not observe the statistically significant association of mean temperature and spread of the COVID-19” (6). c.

It is interesting to note that rs12237222 is in weak but highly significant linkage disequilibrium with rs11139451 ( D ′ = 0.257, P = 1.45 × 10 −6 ) that has been found to show the maximum HLOD score in the study of Allen-Brady et al.

In the meta-analysis of all studies, a nominally significant association with LTL was observed with a rare variant in RPL8 ( p - value = 1.48 × 10 −6 ), which has previously been associated with age.

One-way ANOVA confirms a highly significant effect of infill density on PETG tensile strength (F(2,6) = 259.76, p = 1.49 × 10 −6 ).

The difference between the 2 genotypes was again highly significant ( P = 1.5 × 10 −6 ; n = 11).

In contrast, AF3 exhibits no meaningful separation between binders and non-binders (AUROC = 0.45), and the difference in performance between the two models is highly significant (DeLong test, P = 1.5 × 10 −6 ).

Although they do not pass correction for multiple testing in this analysis, the sites in SCN7A and IQANK1 remain highly significant (unadjusted P =.0000015 and .0000035, respectively) and are among the top 10 most significant sites.

In addition, a highly significant Spearman correlation (Spearman rho = 0.49; p = 1.5e−6) was observed between the normalized supernatant growth effects and the inferred gLV inter-species interaction parameters.

Alternative alleles for another family member, Sb02g029725 ( SbFT6 ), mapping near another flowering QTL, also showed highly significant association with photoperiod response index ( P = 1.53×10 − 6 ).

The ARPC2 gene (ENSG00000163466), mapped to genomic coordinates: chr2p218,217,141–218,254,356, demonstrates a highly significant positive association with UC (β = 1.10, P = 1.53 × 10− 6 ).

Of note, half of the 11-bp inverted site overlaps with a highly significant direct repeat BfmR motif ( P -value = 1.55 × 10 –6 ) that is located between the predicted −35 and −10 elements (Fig. 7D , dotted box).

The main, highly significant finding of our study was that lactate (Discovery group: p<1.6x10 -6 , q = 0.00; Test group: p = 0.003; q = 0.047) and pyruvate (Discovery group: p = 0.017, q = 0.27; Test group: p = 0.010, q = 0.10), two products of anaerobic respiration in glycolysis, were significantly elevated in the PTSD-positive subjects compared to the PTSD negative subjects.

Univariate analyses by pair wise comparison of EFS methylation with the variables listed in table 1 revealed a highly significant correlation of the EFS methylation with the chromosome 3 status (p = 1.6 × 10 -6 ) and cell type (p = 0.006).

A t- test comparing these two groups (SOA < 300 and SOA > 300) is highly significant ( t = −4.80, p < 1.6 × 10 −6 , CI: 43 to 103 ms).

Highly significant enrichment was uniquely found within the first quartile of ranked genes, including transcription regulation (p < 1.62 × 10 -6 ) and regulation of cellular metabolic processes (p < 4.3 × 10 -4 ).

Using data from an independent sample that identified dexamethasone-responsive CpGs on a genome-wide level ( Provençal et al., 2020 ), we observed a highly significant enrichment of dexamethasone-responsive CpGs within the PedBE clock (Fisher's Exact: p = 1.65*10–6, Odds Ratio = 4.36).

In the RIF-M subtype, the dysregulated genes were primarily linked associated with LH + days and smoking status: TM7SF2 exhibited the strongest negative correlation with LH + days ( p = 2.65 × 10 − 5 , R = -0.35), and NFIA demonstrated a highly significant negative correlation with smoking status ( p = 1.69 × 10 − 6 , R = -0.18) (Fig. 4 D).

These differences were quite significant ( p < 1.7 × 10 −6 ) for every five participants.

When applying this approach to ISO and SHORT birds, we find an offset of βiso=0.19 and a nonzero fixed effect of tutoring βshort=0.08 that was highly significant ((βshort≠0, p=1.7*10 -6 , 32 observations, 2 fixed effect coefficients, 8 random effect coefficients).

Compared with Bulgarian control CNVs, we found a highly significant excess of PSD genes within case de novos ( P =1.72 × 10 −6 ; Table 2 ).

For CUI WCE dataset, the performance results for ELM classifier were highly significant such as p = 1.74 × 10 ( − 6 ) for t -test.

These learning-related reductions in activity were also statistically significant in our predefined ROIs in premotor (dorsal premotor cortex – PMd) and parietal cortices (anterior superior parietal lobule – SPLa) ( Figure 3b ): In a 3 (week) x 2 (sequence type) ANOVA on observed activation both main effects and interaction were highly significant in PMd (week: F (2,50) =17.47, p=1.77e −6 ; sequence type: F (1,25) =11.86, p=2.03e −3 ; interaction: F (2,50) =13.22, p=2.46e −5 ) as well as in SPLa (week: F (2,50) =19.14, p=6.73e-7; sequence type: F (1,25) =19.36, p=1.77e −4 ; interaction: F (2,50) =21.59, p=1.74e −7 ).

The difference between the genetic diversity for the data points from the two categories is highly significant (Wilcoxon signed-rank test, p = 1.77 × 10 −6 ).