Excerpts

The results are highly significant with p < 0.000001.

In such a comparison (Figure 1) it will be observed that the distributions appear quite different; the mean AFTPs have a highly significant difference (t = 10.6, P< 10-6, d.f. = 1.721).

Stratification of evidence specific to an umbrella review We performed an umbrella review-level stratification of evidence using modified criteria recommended by Fusar-Poli et al [ 19 ] : Convincing evidence (Class I) when the number of cases (deaths) > 1000, highly significant summary associations (random-effects P < 10 −6 ), no evidence of small-study effects, no evidence of excess significance bias, 95% prediction intervals excluding the null, and not large heterogeneity (I 2 < 50%); Highly suggestive evidence (Class II) when the number of cases > 1000, random-effects

Highly significant differences in the levels of composite biomarkers were found between AD groups and normal controls ( p < 0.000001, one-way ANOVA), whereas differences in the levels of a single biomarker were only significant at the level of 0.001 (Fig. 4a–f and Supplementary Fig. 28 ).

Genes differentially expressed in association with upl3‐5 are linked to stress responses and metabolism To identify the biological processes that were most likely influenced by the mutation in AtUPL3 in association with infection by cyst nematodes, we focused on genes that showed highly significant differential expression between the upl3‐5 mutant and wild‐type Arabidopsis plants (−log 10 ( P ) > 6).

To individually test candidate SNP pairs for interaction, we tested the nominally significant interaction results ( P < 1.0x10 -6 ) from the PLINK[ 63 , 64 ] epistasis test.

However, for intergroup comparison, the difference between the two modes was found to be highly significant in both sedated and awake states if we considered inspiratory hold in PAV+ as PMI ( P = 0.000001 for both states).

The differences between the various times were highly significant (P << 10 −6 , unpaired t test).

A very highly significant increase of Ang‐2 concentration ( p < 0.000001) was observed in CSF of MA patient in comparison with CTRL subjects (Fig. 1A ).

Borderline significance (5 × 10 −8 < p < 1 × 10 −6 ) for association with systolic BP was achieved for four index SNPs at four separate loci; there were four SNPs showing borderline significant associations with diastolic BP at four separate loci.

The Phi test for recombination was highly significant ( p =10 −6 ).

The difference, when tested by a likelihood ratio test, is highly significant (likelihood ratio chi-square = 931.0514, DF = 17, p < 0.000001).

Despite the fact that single, silent substitutions can not be detected in the selective system, we observed a highly significant correlation in mutable positions between the in vivo and in vitro spectra (Pearson linear correlation coefficient = 0.79, P<10 −6 ).

This is a highly significant enrichment relative to the <3% of background genes with known interactions (Fisher’s test p < 10 −6 ), confirming that our analytical pipeline is an effective approach to enrich for druggable targets. 645 (34%) of the compounds are predicted in a single patient, ranging from 15 in patient 17 to 205 in patient 18, further highlighting the importance of a patient-specific approach (Fig.

This is in accordance with Christoph et al .’s study, which reported a statistically highly significant ( P < 0.000001) result, showing non-buffered local anaesthesia to be 2.8 times more painful than buffered local anaesthesia.

Results The statistical analysis of the Dice coefficients and the BLD values resulted in highly significant differences (p<10 −6 ) for the 5-mm and 8-mm local RRs vs the global, bony and 1-mm local RRs.

An additional 79 variants were marginally significant ( p < 1.00E-06) and are described in Supplementary Table S3 .

SNP with call rates < 0.98, minor allele frequencies (MAF) < 0.03 and highly significant deviations ( P < 10 -6 ) from Hardy-Weinberg Equilibrium (HWE) were also excluded.

Multivariable models indicated that both HNSCC occurrence and tumor location were highly significant (p ≤ 1e-06 for each variable) after adjusting for age, biological sex, and smoking history ( Fig. 1A ).

Both changes in slope, before and after 1994 to 2002, were highly significant (p < 10 -6 in both cases).

We find subtle, but highly significant (p < 10 −6 ) differences in relative height and relative radius between the two populations ( Fig. 2e, g ).

the nascent bond show that all of these active site dynamics are highly significant with p < 10 −6 ( Fig.

There were, however, several nominally significant associations with p -values <1 × 10 −6 .

There was a highly significant correlation between COX-2 and PCNA levels in tumours (r's = 0.7896; P = 0.000001) and VEGF in tumour samples (r's = 0.4610; 2 P = 0.0320).

An umbrella review of systematic reviews and meta-analyses evaluating the association between environmental risk factors and AD showed that late-life depression and type 2 diabetes mellitus are the most significant; cancer, depression at any age, and physical activity are also highly significant ( p < 10 −6 ) in AD development.