Excerpts

Despite the small sample number, these changes were highly significant ( P values in a 1-way ANOVA: DUSP11 : 9 hours: P = 1.11 × 10 −8 ; 24 hours: P = 6.27 × 10 −13 ; SRRM1 : 9 hours: P = .00031; 24 hours: P = 1.47 × 10 −9 ).

This raises the question whether the observed alteration in mib1 ta52b mutant neural tube proportions may be a secondary consequence of this reduction in cell number? Our observations argue against this hypothesis: First, the injection of NICD promotes a partial but clearly significant (p = 1.14E-08) restoration of neural tube proportions (Fig. 8p,q ) while triggering only a minor and non-significant (p = 0.129) increase in neural tube cell number (Supplementary Fig.

421.33 ± 8.80 pg/mL, respectively, and the difference remained highly significant after adjustment for age and sex ( p = 1.14 × 10 −8 ).

A separate Kruskal-Wallis test for geographical regions also indicated a highly significant effect ( H = 36.56, p = 1.141E-08), with Dunn-corrected comparisons confirming that both the Silesian Upland and the South Greater Poland Lowland differed significantly from the Silesian Lowlands ( p < 0.001), whereas their mutual contrast remained non-significant.

Most importantly in terms of coevolutionary dynamics, the interaction between mosquito species and parasite genetic population had a highly significant effect ( P = 1.191 × 10 −08 ; fig. 5 ).

For example, of the 559 genes in the Chen androgen signature (448 of which were represented in at least three prostate tumor datasets), 29 were correlated ( p <0.05) with KLK3 in at least three out of the four prostate tumor datasets; by chance, nine were expected, and so the amount of actual overlap was quite significant ( p = 1.2E-08).

For the same set of 1392 genes, the most highly significant canonical pathways were “Synaptic Long Term Depression” ( P = 1.2e-8), “Axonal Guidance Signaling” ( P = 3.4e-7), “CREB (cAMP response element-binding protein) Signaling in Neurons” ( P = 4.3e-7), “Neuropathic Pain Signaling in Dorsal Horn Neurons” ( P = 4.7e-7), and “Melatonin signalling” ( P = 5e-7).

For the Breast Cancer Ultrasound dataset, even with a smaller average improvement (0.36%, SD ± 0.01%, CI [0.36, 0.37]), the p-value remained highly significant (p = 1.23e − 8).

The Kruskal–Wallis H test showed highly significant effects of water treatment on both plant height ( p =1.23×10 -8 ) and petiole count ( p = 4.40×10 - 12 ).

Analysis of the strain differences produced highly significant results using both ANOVA and the non-parametric Kruskal-Wallis test (p-value = 1.25×10 −8 and 2.37×10 −5 , respectively).

This finding was highly significant, suggesting that individuals with poor sleep quality experience significantly more severe symptoms of IPD ( p = 1.25 × 10 −8 ).

There was a highly significant positive relationship between tissue 13 C and 15 N for pitchers harvested 3-h after receiving U-Phe at both Fort Albany ( P = 1.28×10 −8 ; Fig. 3C ) and Tom Swamp ( P = 7.17×10 −8 ; Fig. 3D ).

5 e), TMB values also increased with the progression of the stage, with highly significant differences in TMB between T2 and T4 ( p = 1.3e−08) and between T1 and T4 ( p = 0.0001).

Accordingly, we found highly significant interactions between temperature and sex ( χ 2 = 36.4, p = 1.3e‐08).

For NEUROD1 , both promoter and gene body methylation give a highly significant prediction (p value = 1.3e-08) ( Figure 5 , upper left).

Integrating genome-wide association study of 47 F 2 roosters with population resequencing ( n = 50), we identified a highly significant locus on chromosome 33 ( P = 1.35E−8) harboring PMEL as the sole credible candidate.

A Wilcoxon test of higher expression of the “little” exon in those over 10 years old across all brain regions was highly significant ( p -value = 1.386e−08).

If we solely consider the overlap amongst the eight brain studies, there is relatively low, but highly significant, levels of replication (p = 1.4e −8 ).

For this list of 1409 DETs unique to the ASD GI ileal biopsies, the Diseases and Disorders category returned highly significant associations with: (1) gastrointestinal disease [217 genes; p = 1.4×10 −08 ] including inflammatory bowel disease [42 genes; p = 3.2×10 −05 ] and colitis [25 genes; p = 8,8×10 −04 ] and (2) inflammatory response [198 genes; p = 3.8×10 −07 ] including inflammation of organ [88 genes; p = 3.8×10 −7 ], antibody response [27 genes; p = 2.1×10 −6 ] and activation of leukocytes [74 genes; p = 4.9×10 −6 ].

Beloniformes Based on independent contrasts, the relationship between the number of abdominal vertebrae and log FR is highly significant (r = 0.61, P = 1.42 × 10 -8 ; df = 66; Figure 7 a); that between the number of caudal vertebrae and FR is also significant but the correlation is not as strong (r = 0.4, P = 3.30 × 10 -4 ; df = 66), and that between the number of abdominal and caudal vertebrae is also significant and positive (r = 0.57, P = 2.33 × 10 -7 ; df = 66; Figure 7 b).

The statistical analysis of antioxidant capacity confirmed significant differences among the tested materials, with ANOVA results ( Table S5, Supplementary Materials ) indicating a highly significant effect (F = 73.01071, p = 1.46 × 10 −8 ).

Compared to the dfmr1 mutants, the Trhn overexpression results in a highly significant elevation of serotonin in the MB ( UH1 -Gal4 driven Trhn overexpression; p = 1.477 × 10 –8 ), with a similar elevation from the other drivers (Fig. 2 D, right).

Pantoprazole induced highly significant suppression across all genes at both 50 μg/mL and 100 μg/mL, with comparable p-values (p = 1.49 × 10 -8 ; BH-adjusted p = 1.49 × 10 -8 ), highlighting a consistent and substantial inhibitory action ( Figure 17a ).

It was not part of any batch effect, it was detected by three methods, there was a statistically highly significant level of agreement between 16S amplicon sequencing and both metagenomics ( P= 1.5 x 10 -8 ) and a targeted PCR/qPCR assay ( P =9.7 x 10 -21 ), none of 47 negative controls analysed by 16S sequencing were positive for S. agalactiae, and there was no association with mode of delivery ( Extended Data Fig. 7 ).

The association of decreased FGF13 expression with POAF was highly significant ( P =1.52x10 −8 , FDR=0.0001) after controlling for age, sex, and corrected QT.