Barely Significant

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highly significantp < 10 −80.0× alphaqualifiedgold
These genes were chosen on the basis of showing highly significant self-linkage ( p < 10 −8 ) and at least a 1.2-fold difference in expression between segregants bearing the BY and RM alleles, such that no false positives and only one chance trans linkage due to a nearby gene were expected (see Materials and Methods ).
highly significantP < 1 × 10 −80.0× alphaqualifiedgold
Serum levels of 10 biomarkers correlated (r > 0.2, P < 0.05) with the level of fT4 and 12 with the level of TRAb (Supplementary Table). Six biomarkers showed a highly significant increase ( P < 1 × 10 −8 ) between patients with GD and HS ( Fig. 2 ), most significant for TNF receptor superfamily member 9 (TNFRSF9).
Novel inflammatory biomarkers in thyroid eye disease.
Eur J Endocrinol · 2022 · PMC9723260
highly significantp = 0.000000010.0× alphaqualifiedgold
Because of this bias, PBIF modeling found a larger decrease in V T in cannabis smokers (−27% in the prefrontal cortex compared with −19% using full input), and the group×region interaction was statistically highly significant (F = 17.1, p = 0.00000001) ( Fig. 2B ).
highly significantp < 10 -80.0× alphaqualifiedgold
Both the integrated fluorescence intensities, which represent the amount of DNA per nucleoid ( Figures 3B,D and Table 1 , columns 11 and 12), and the measurements of nucleoid lengths ( Table 1 , columns 13 and 14) indicate that the difference in DNA between small and large deeply-constricted cells at the fast growth rate is highly significant ( p < 10 -8 , as determined by a two-tail t -test); at the slow growth rate, the difference remains significant, but just barely ( p = 0.035).
highly significantp <10 −80.0× alphaqualifiedgold
Statistical analysis showed that the increase in inter-click angle was highly significant ( Figure 2A , bottom: one-way ANOVA: F >71, p <10 −8 ; post-hoc t tests: p <10 −11 for comparing one-object experiments after locking versus no-object experiments; p <10 −6 for multiple-object experiments after locking versus one-object after locking).
highly significantP -value < 1 × 10 −80.0× alphaqualifiedgold
Compared to peaks containing L-CTCF-BSs, P-CTCF-BSs exhibited a higher mutation rate of 1.34 and 1.25 times per CTCF-BS for LNCaP and MCF7 respectively ( Supplementary Table S4 ), and the elevated rate is highly significant ( P -value < 1 × 10 −8 ) as determined by a permutation test (Materials and methods) (Figure 2A , B ).
highly significantp = 1 × 10 ‐ 80.0× alphaqualifiedgold
There was no significant difference in the family effect between years (interaction family × year not significant; LRT: χ 2 = 1.2; df = 2; p = .552), but the family effect was highly significant ( χ 2 = 32.6; df = 1; p = 1 × 10 ‐ 8 , Table S2 ) and the heritability of the sensitivity to vernalization was 0.19 (±0.04) (Table 2 ).
highly significantp < 10 −80.0× alphaqualifiedgold
While we found no obvious and consistent correlations between GWAS gene significance and FCs (electronic supplementary material, figure S4 a–g ), we identified GRIN2A and KCNB1 with highly significant GWAS associations ( p < 10 −8 ) in all seven diseases, and more strongly upregulated TL (FDR < 0.05, log 2 FC (TL/FL) > 1) in either both INH/EX ( GRIN2A ) or in INH ( KCNB1 ) ( figure 1 f,h ).