Excerpts

Strain energy as an empirical benchmark for CoA-induced arterial stiffening In the proximal aorta, there was a highly significant main effect of group (ANOVA p = 8.3 × 10−9), with post-hoc comparisons showing that all Prolonged CoA groups exhibited markedly elevated strain energy relative to controls (Fig. 1 ).

1A ); we also observed a highly significant positive correlation (Spearman P = 8.4 × 10 −9 ) between ERBB2 and ERBB3 mRNA expression ( Fig. 1B ).

Mitochondrial DNA content was modestly but significantly higher in 8WVeh skeletal muscle than chow-fed counterparts (32.5 ± 5.5 ng/μl and 17.3 ± 5.4 ng/μl, respectively, P = 0.046), but that difference was highly significant in 16W (92.2 ± 24.1 ng/μl in 16WVeh and 7.5 ± 2.4 ng/μl in chow-fed controls, P = 8.4 × 10 –9 ).

The difference between preoperative and early postoperative mLDFA was highly significant ( p = 8.4e–9), as was the difference between preoperative and final follow-up mLDFA ( p = 4.3e–7).

SPMS was compressed using PCA, now including all patients (except the transitioning patients), resulting in a large and highly significant (p=8.5×10 -9 ) separation over the first principal component ( Figure 4 A ).

The association of the WGS with baseline eGFR was modest but highly significant (B = −1.68 (standard error (SE), 0.29), R 2 adjusted = 0.010; P = 8.6 × 10 −9 ).

Accordingly, the inverse correlation between FASN protein expression and global FASN gene methylation as captured by mean beta value was highly significant ( R = −0.34; P = 8.7 × 10 −9 ; Fig. 2B ), with comparable correlations seen for each individual probe ( Supplementary Table S1 ).

We found that recombination happened more often in the middle of core regions at a small but highly significant level (Kolmogorov-Smirnov test; p-value=8.8e-09).

The correlation between these phenotypes is numerically small ( r 2 = 0.03) but highly significant ( p = 8.89 × 10 − 9 ), likely due to the large sample size.

We again confirmed a highly significant association in an overall analysis stratified for the populations, with an odds ratio of 0.46, 95% CI 0.35–0.60, P = 8.94 × 10 −9 (Table 1 ).

Both skewness and CV successfully detected microtubule bundling during PPB formation, with the skewness and CV values for differences between the images with and without bundling being highly significant, but more so for CV (Mann–Whitney U-test, P = 8.947e−09 for skewness and P = 6.202e−14 for CV; Fig. 3 B, C, Supplemental Fig. 5 B).

CeaGO analysis reported "chemokine" as highly significant from a statistical perspective ( p -value = 9e-09 for cluster NO. 1, and 3.4e-06 for cluster NO. 2).

Both allelic and genotypic comparisons between Patna and Vaishali districts were highly significant (allelic χ 2 2 = 37.1, P = 9 x 10 −9 ; genotypic: χ 2 3 = 21.4, P = 9 x 10 −5 ).

Two microRNAs, miR-29a and miR-29c, were disclosed and further meta-analysis of the six mRNA expression datasets showed that these two microRNAs were highly significant based on the Fisher p-value combination (p = 9.14×10 −9 for miR-29a and p = 1.14×10 −6 for miR-29c).

The ANOVA of flaA -SVR groups from caecal isolates demonstrated a highly significant difference in the numbers of isolates between flaA -SVR groups ( P = 9.37 x 10 −9 ).

Among them, the MCV level was highly significant (nominal p = 9.8×10 −9 ) in association with the DYRK1A -SNP1 (c.2989 G<A), and explained 4.9% of the phenotypic variance.

5e ), and the difference in means was overall highly significant ( p = 9.95 * 10 −9 , two-sided t -test based on the data in Fig. 5d ).

All of the heritability and correlation estimates were highly significant ( p < 1 × 10 −8 ).

When we assessed the relationship between these two major allele classes and the above-described symptomatic and asymptomatic disease outcomes, we found a highly significant ( P < 1e −08 ; analysis of variance [ANOVA], F 2,43 = 30.06) relationship between allele class and disease outcome such that those CC-RIX mice homozygous for the classic inbred allele showed an enhanced propensity for symptomatic disease outcomes.

This enrichment is highly significant, as only 5.5% of informative sites overlap a DSB hotspot (p < 10 −8 , calculated from 10 8 permutations; see ‘Materials and methods’—‘Inclusion criteria’).

Biological underpinning of the shared genetic components—translational evidence from mice For each of the Master PCs, the top-500 correlations across all records of the Amygdala Cohort Database, ranked by the Genetic Correlation (Spearman's rho), were strong (absolute value ranging from 0.7 to 0.9), and highly significant ( p < 10 −8 , Supplementary Tables 5, 6 ).

Statistical analysis of the asexual parasite prevalence by Chi-square test showed a highly significant reduction of the prevalence with increasing altitude ( χ 2 = 55.74, df =2, p =10 −8 ).

In this analysis, 263 p53 target genes were co-bound by JMJD3, which gives a highly significant overlap between JMJD3 and p53 target genes (p<10 −8 ).

Indeed, Pearson correlation between E2F1 and CCND1 is close to 0 and not statistically significant ( P = 0.4) while the MI is highly significant ( P = 10 − 8 ).

In new Figure 3D , the cluster area plot shows a visible and statistically significant difference in ZitP cluster area between the swarmer and stalked poles as supported by the highly significant difference observed (p < 10 -8 ).