Excerpts

Enrichment for membrane-bound proteins was highly significant ( P = 5.6E−10) in adults but not in nauplii.

While TET2 -CH, for example, showed a highly significant slope when regressed on barcode-CH ( m = 0.94, P = 5.64 × 10 −10 ), the slope for ASXL1 -CH versus barcode-CH was much shallower and of lower significance ( m = 0.41, P = 8.76 × 10 −4 ).

Enrichment of rare/novel DHX37 missense variants in 46,XY DSD is highly significant compared with controls ( P value = 5.8 × 10 −10 ).

This yielded a highly significant fit (Pearson’s R 2 = 0.438, p = 5.8 × 10 −10 ) and a clear relationship between reduced cGMP signaling and shorter stature.

PBB exposure was highly significant in the EPM regression model ( p = 5.9 e − 10) but not the penalized regression model ( p = 0.141). 3 Discussion Epigenetic clocks are widely used biomarkers that can accurately predict the age of an individual based on their methylation pattern.

Highly significant GO terms associated to biological processes were identified, including: homophilic cell adhesion via plasma membrane adhesion molecules (P = 5.97E-10, false discovery rate, FDR, 3.93E-6); cell-cell adhesion via plasma membrane adhesion molecules (P = 6.31E-8, FDR 2.08E-4); nervous system development (P = 8.82E-6, FDR 1.93E-2); cell-cell adhesion (P = 1.66E-5, FDR 2.74E-2); biological adhesion (P = 2.89E-5, FDR 3.8E-2).

Furthermore, the Kaplan-Meier analysis for metastasis-free survival (MFS) demonstrated a highly significant difference between the groups predicted to have good or poor prognosis ( P = 6.0e-10, HR = 7.26, 95% CI 3.49, 15.08) (Figure 1 B).

Paired t-test of quantitative scoring of sputum bacillary load at baseline and post-treatment revealed that the decrease in V5 group was highly significant (from mean/median 2.2 ± 0.98/3 to 0.29 ± 0.55/0; P = 6E-010) but no difference was seen in placebo recipients (1.9 ± 0.99/1.5 to 1.8 ± 1.03/1; P = 0.34).

However, after PTPN22 the second most significant association is observed on chromosome 2 in the region of REL , where two markers provide highly significant evidence of association (rs13031237, allele specific p=6.01 × 10 -10 and rs13017599, allele specific p=9.05 × 10 -9 ), as shown in Table 1 .

The 19 F NMR dataset acquired was then analysed using a completely randomised design (one-way) type 1 analysis-of-variance (ANOVA) model, and this demonstrated that although there were no significant “between-participant” differences in δ values found (range of mean values −119.41 to −119.33 ppm only, p = 0.071), that between Δv 1/2 was very highly significant indeed, with p = 6.02 × 10 −10 .

With respect to loci identified by GWI candidate gene studies [ 50 – 52 ] and the previous GWI genome-wide association study (GWAS) (Table S7) [ 16 ], we observed nominally significant interaction with exposure to biological/chemical or warfare agents for GWAS-identified locus rs142258944*C (G×E beta = 0.625, joint- p = 6.04 × 10 − 10 , interaction- p = 0.005) and candidate locus PON1 rs662*C (G×E beta = 0.345, joint- p = 0.036, interaction- p = 0.012).

gondii dataset showed highly significant improvements over ResNetKhib ( p = 6.11 × 10−10), DeepKhib ( p < 10−16), iLys-Khib ( p < 10−16), and KhibPred ( p < 10−16).

Differences in the extent of linkage disequilibrium were highly significant (p<6.2×10 −10 ) for all population pairs except Germans and British ( Fig. 7 ): LD was highest in Eastern Finns and lowest in Germans and British.

( 2011 ) gave an extremely significant coefficient of MLS determination ( R 2 = 0.713, P = 6.2E-10, n = 37), which is very close to that obtained on much bigger dataset of mammals ( R 2 = 0.703, P < E − 25, n = 215; unpublished data).

The effect of experience was altogether highly significant ( χ 2 (2) = 42.4; p = 6.3E−10).

There was a highly significant overlap, with 22% of the core nitrate induced genes being suppressed in the roots of the H6 transgenic line ( p < 6.4E‐10) (Figure S4 ).

Between the 10 circRNA variants derived from the NRIP1 gene predicted, only one showed highly significant downregulation in the NSCLC samples ( p = 6.49 × 10 −10 ; FDR = 3.07 × 10 −6 ) (criterion #3).

Only a small number of patients were identified to carry CREBBP mutations, therefore to more holistically link CREBBP-activity to ferroptotic susceptibility, we correlated gene sets involved in ferroptosis with CREBBP expression, demonstrating a highly significant negative correlation ( R = –0.42, p = 6.6e –10 ) (Supplementary Data Table 4 , Fig. 5f ).

The step wise reduction in the SVR rate associated with the increase in the number of TOPs present at baseline was highly significant (logistic regression P = 6.6 × 10 −10 ).

Moreover, patients with genotype TC were likely to have higher age-at-onset migraine than patients with the wild type. Associations in the subgroups with aura In all migraine cohorts with aura, 3 SNPs had P < 5 E-08 (rs77630941 in CUX1 , rs146778855 in CDH18 , and rs117608715 in NOL3 ) and 1 SNP (rs150592309 in PRAP1 ) were almost significant in the aura groups ( P = 6.66 E-10, P = 1.21 E-08, P = 1.78 E-08, P = 8.88 E-08, respectively in Fig. 4 A–D).

S1 D ), a highly significant incidence ( P = 6.7E-10) compared to the expected frequency of pathogenic BLM mutations in the general population of 1 in 900 ( 25 ), and as high as the 1-in-100 incidence among people of Ashkenazi Jewish ancestry, who carry a specific set of mutations ( 29 ) that were not found in any of our patients, as none of them were of Ashkenazi Jewish ancestry.

Although the observed sign concordance of 52% is not significantly different from a random pattern ( P = 0.40), we find 3.23 times more SNPs in this set of 506 SNPs that are nominally significant for SZ than expected given the distribution of the P values in the SZ GWAS results (raw enrichment P = 6.87 × 10 −10 ).

This shift was also highly significant (p = 7 × 10 -10 ) in the 23 paired normal and tumor samples, where a lower ratio was observed in all 23 tumor samples (Additional file 1B ).

p value of F‐statistics was highly significant ( p = 7.049e‐10).

The increase in probability of violation associated with having predecessors is highly significant (Fisher’s exact test; p = 7.2 × 10 −10 ).