Excerpts

The association between viral type and host taxa on either side of the cline centre is highly significant (χ 2 = 42, df = 1, p = 9.1 x 10 −11 ).

The weight of PbA-C57BL/6 mice started to decrease significantly on day 6 post infection and was the lowest on day 8 both in groups A (− 0.08 ± 0.05% decrease) and B (− 0.08 ± 0.02% decrease), when there was a highly significant difference between the PbA-infected group and the uninfected control group ( p = 9.27 × 10 −11 , Student’s t test) (Fig. 2 a).

The regression model was highly significant (F = 33,119.09, p = 9.51 × 10− 11 ), with slope of 1.0150 (95% CI 1.0007–1.0293) and intercept of 1.0626 (95% CI 1.0327–1.0924), confirming statistical significance of both parameters.

Second, our study had excellent statistical power, yielding highly significant MR associations for IFNAR2 ( P =9.8×10 -11 ), increasing confidence in the validity of the much weaker signals for IFNAR2 reported in the GenOMICC study ( P =0.004), particularly as the earlier report had displayed evidence of confounding by LD ( P HEIDI = 0.015). 37 Indeed, compared to the analysi

The differences are highly significant (TT mean – TM mean: P = 9.99E − 11 ; TT mean – TM median: P = 0.0013, KS-test, two-sided, α = 0.05).

These overlaps are highly significant ( P <10 −10 , hypergeometric test).

The first four inferred edges are highly significant (p<10 −10 for m = 1 to m = 4), the last one however to a much lesser extent (p = 0.009).

At least one error affecting a whole chromosome was detected for total of 15,842 (62.1%) of the remaining 25,497 blastomeres as compared to 7,623 (44.3%) of 17,219 TE biopsies, a highly significant difference [ χ 2 (1, N = 42,716) = 1323.8, P < 1 × 10 −10 ].

When plotting the solubility and disorder scores at neutral pH (pH = 7.0), a highly significant linear correlation was observed between these two variables (R 2 = 0.90, p < 1 −10 ) ( Figure 3 ), suggesting that solubility and disorder are intimately ligated in this dataset.

The top four most enriched terms among upregulated genes were extremely significant, with a p -value < 10 −10 .

This revealed a moderate, but highly significant, correlation between responses to the two interventions in RCC4 cells (Pearson’s r = 0.33, P < 1 × 10 −10 , Fig. 3d left panel).

However, gene ontology enrichment analysis revealed a highly significant enrichment of glycolysis-associated proteins ( P < 10 10 ), with downregulation of the entire glycolytic pathway, and conversely an upregulation of AMP-activated protein kinase signaling– and autophagy-associated proteins, promoting catabolic pathways to generate more ATP.

Finally, we also fitted a linear model that included the interaction between the mother and father genotypes with temperature and found that this interaction was highly significant (LRT: χ 2 = 303.9, df = 8, P < 1 × 10 −10 ).

There was a highly significant agreement (Pearson's R = 0.41, P < 10 −10 ) between the model prediction and the measured changes in protein levels, with the model also quantitatively matching the proportional relationship (gradient of slope = 0.75) (Fig 6 F).

In these studies, a highly significant ( P <1×10 −10 ) association was detected for CDKAL1 , in accordance with the present study in Japanese.

Using this epilepsy model, we were able to demonstrate that the genetic pH reporters E 2 GFP and deGFP4 are able to detect a highly significant negative shift in pH during epileptiform activity (E 2 GFP: P < 10 −10 , n = 40, deGFP4: P < 10 −7 , n = 19, paired t test).

This difference is highly significant statistically (P < 1.0E-10, Chi-square test).

These differences in the proportion of observed gene conversion events in K a and in K s between the RP and MP groups are highly significant ( P < 10 −10 and P < 0.002, respectively; Fisher’s exact test).

The altered group had a significantly higher mutation count (median 158.5) compared with the unaltered group (median 56), with a highly significant difference ( p < 1E-10).

Emmetropization There was strong evidence of emmetropization (Figures 4(a) and 4(b) ) in RAR and ROP Sprague-Dawley rats ( dashed light blue and light red lines ) as well as ROP Long-Evans rats ( dark red lines ) resulting in a highly significant effect of age ( F (age) = 32.6, df = 2,78, P < 10 −10 ).

The results showed that 52 genes were shared in these two gene sets, and this overlap was highly significant by hypergeometric test (p-value < 10 −10 ), indicating a strong connection between AD and PD at the molecular level.

This difference is highly significant (P<10 −10 , Mann-Whitney U-test, n = 100) [59] .

1 B, were 0.45 ± 0.13 (standard deviation) and 0.92 ± 0.07, respectively; the difference was highly significant (P < 10 −10 , t test for paired measurements).

We detected highly significant broad-sense heritability for sensitivity ( H 2 sens = 0.37, 0.14, and 0.21 for cisplatin, EMS, and HU, P < 10 −10 in all cases).

5 , 6 , p < 0.05, false discovery rate (FDR) corrected], and in nine such comparisons, results were highly significant (Figs. 5 , 6 , p < 10 −10 , FDR corrected); see Supplementary Data 5 for AUC histogram bin data (bootstrapped resamples).